Science Magazine
WHO panel puts off decision on whether to sound alarm on rapid spread of new virus  Science Magazine · 7 hours
Group of experts wants more data before calling coronavirus outbreak an international health emergency more
Deadlocked WHO panel puts off decision on global virus alarm  Science Magazine · 10 hours
Group of experts wants more data before calling coronavirus outbreak an international health emergency more
Single-cell morphology encodes metastatic potential  Science Magazine · 13 hours
A central goal of precision medicine is to predict disease outcomes and design treatments based on multidimensional information from afflicted cells and tissues. Cell morphology is an emergent readout of the molecular underpinnings of a cell’s functions and,... more
Deficient histone H3 propionylation by BRPF1-KAT6 complexes in neurodevelopmental disorders and cancer  Science Magazine · 13 hours
Lysine acetyltransferase 6A (KAT6A) and its paralog KAT6B form stoichiometric complexes with bromodomain- and PHD finger-containing protein 1 (BRPF1) for acetylation of histone H3... more
Animal simulations facilitate smart drug design through prediction of nanomaterial transport to individual tissue cells  Science Magazine · 13 hours
Smart drug design for antibody and nanomaterial-based therapies allows optimization of drug efficacy and more efficient early-stage preclinical... more
Compression-induced dedifferentiation of adipocytes promotes tumor progression  Science Magazine · 13 hours
Dysregulated physical stresses are generated during tumorigenesis that affect the surrounding compliant tissues including adipocytes. However, the effect of physical stressors on the behavior of adipocytes and their cross-talk with tumor cells remain elusive.... more
Molecular identification of fungi microfossils in a Neoproterozoic shale rock  Science Magazine · 13 hours
Precambrian fossils of fungi are sparse, and the knowledge of their early evolution and the role they played in the colonization of land surface are limited. Here, we... more
Different motilities of microtubules driven by kinesin-1 and kinesin-14 motors patterned on nanopillars  Science Magazine · 13 hours
Kinesin is a motor protein that plays important roles in a variety of cellular functions. In vivo, multiple kinesin molecules are bound... more
Multi-isotope evidence for the emergence of cultural alterity in Late Neolithic Europe  Science Magazine · 13 hours
The coexistence of cultural identities and their interaction is a fundamental topic of social sciences that is not easily addressed in prehistory. Differences in... more
Novel CD11b+Gr-1+Sca-1+ myeloid cells drive mortality in bacterial infection  Science Magazine · 13 hours
Extreme pathophysiological stressors induce expansion of otherwise infrequent leukocyte populations. Here, we found a previously unidentified CD11b+Gr-1+ myeloid cell population that expresses stem cell antigen-1 (Sca-1) induced upon experimental infection... more
Seismic evidence for megathrust fault-valve behavior during episodic tremor and slip  Science Magazine · 13 hours
Fault slip behavior during episodic tremor and slow slip (ETS) events, which occur at the deep extension of subduction zone megathrust faults, is believed to be... more
Atmospheric CO2 levels from 2.7 billion years ago inferred from micrometeorite oxidation  Science Magazine · 13 hours
Earth’s atmospheric composition during the Archean eon of 4 to 2.5 billion years ago has few constraints. However, the geochemistry of recently discovered iron-rich... more
Imperceptible magnetic sensor matrix system integrated with organic driver and amplifier circuits  Science Magazine · 13 hours
Artificial electronic skins (e-skins) comprise an integrated matrix of flexible devices arranged on a soft, reconfigurable surface. These sensors must perceive physical interaction spaces... more
Isothermal digital detection of microRNAs using background-free molecular circuit  Science Magazine · 13 hours
MicroRNAs, a class of transcripts involved in the regulation of gene expression, are emerging as promising disease-specific biomarkers accessible from tissues or bodily fluids. However, their accurate quantification from biological... more
Monoubiquitination of p120-catenin is essential for TGF{beta}-induced epithelial-mesenchymal transition and tumor metastasis  Science Magazine · 13 hours
Disassembly of intercellular junctions is a hallmark of epithelial-mesenchymal transition (EMT). However, how the junctions disassemble remains largely unknown. Here, we report that E3... more
Dense hydroxyl polyethylene glycol dendrimer targets activated glia in multiple CNS disorders  Science Magazine · 13 hours
Poor transport of neuropharmaceutics through central nervous system (CNS) barriers limits the development of effective treatments for CNS disorders. We present the facile synthesis... more
[Editors' Choice] Hitting a double to treat cancer  Science Magazine · 13 hours
Simultaneous targeting of polyamine and methionine pathways may be a promising strategy to treat prostate cancer. more
[Editors' Choice] Angling for a bug-inspired method of coating therapeutics onto microneedles  Science Magazine · 13 hours
Mimicking the microstructures on the surface of European true bugs may help optimize loading of therapeutics onto transdermal microneedle patches. more
[Research Articles] PI4KIII{beta} is a therapeutic target in chromosome 1q-amplified lung adenocarcinoma  Science Magazine · 13 hours
Heightened secretion of protumorigenic effector proteins is a feature of malignant cells. Yet, the molecular underpinnings and therapeutic implications of this feature remain unclear.... more
[Research Articles] Pan-viral protection against arboviruses by activating skin macrophages at the inoculation site  Science Magazine · 13 hours
Arthropod-borne viruses (arboviruses) are important human pathogens for which there are no specific antiviral medicines. The abundance of genetically distinct... more
[Focus] Deep phenotyping during pregnancy for predictive and preventive medicine  Science Magazine · 13 hours
Deep phenotyping during pregnancy offers an opportunity to define the antecedents of lifelong health and wellness, and to improve pregnancy outcomes. more
[Research Articles] The IDH-TAU-EGFR triad defines the neovascular landscape of diffuse gliomas  Science Magazine · 13 hours
Gliomas that express the mutated isoforms of isocitrate dehydrogenase 1/2 (IDH1/2) have better prognosis than wild-type (wt) IDH1/2 gliomas. However, how these mutant (mut)... more
Arrival of new SARS-like virus in U.S. heightens concerns about global spread  Science Magazine · 1 day
Chinese officials confirm that the coronavirus spreads between people, making it harder to control more
Cataclysmic bashing from giant planets occurred early in our Solar System's history  Science Magazine · 1 day
Models and observations suggest that an earlier date for the upheaval can explain puzzles including a puny Mars more
What does traditional music around the world have in common?  Science Magazine · 1 day
An analysis of thousands of song descriptions ties together music from different cultures more
Campus attacks by nationalists and police alarm India’s scientific community  Science Magazine · 3 days
Scientific establishment, traditionally apolitical, is increasingly speaking out against the Modi government more
Attack by nationalist hoodlums and police brutality shake India’s academic community  Science Magazine · 3 days
Scientific establishment, traditionally apolitical, is increasingly speaking out against the Modi government more
China reports more than 200 infections with new coronavirus from Wuhan  Science Magazine · 3 days
Beijing and Shenzhen both have cases; Korea becomes third affected country outside China more
Scientists find way to make diphtheria treatment without injecting horses with toxin  Science Magazine · 5 days
Animal welfare group PETA funds alternative to Nobel prize-winning way to make antitoxin more
Airway brush cells generate cysteinyl leukotrienes through the ATP sensor P2Y2  Science Magazine · 6 days
Chemosensory epithelial cells (EpCs) are specialized cells that promote innate type 2 immunity and protective neurally mediated reflexes in the airway. Their effector programs and modes... more
Gasdermin E-mediated target cell pyroptosis by CAR T cells triggers cytokine release syndrome  Science Magazine · 6 days
Cytokine release syndrome (CRS) counteracts the effectiveness of chimeric antigen receptor (CAR) T cell therapy in cancer patients, but the mechanism underlying... more
Monolithic mtesla-level magnetic induction by self-rolled-up membrane technology  Science Magazine · 6 days
Monolithic strong magnetic induction at the mtesla to tesla level provides essential functionalities to physical, chemical, and medical systems. Current design options are constrained by existing capabilities in three-dimensional (3D) structure construction,... more
Light-degradable hydrogels as dynamic triggers for gastrointestinal applications  Science Magazine · 6 days
Triggerable materials capable of being degraded by selective stimuli stand to transform our capacity to precisely control biomedical device activity and performance while reducing the need for invasive interventions. Here, we describe... more
Biophysical and biomolecular interactions of malaria-infected erythrocytes in engineered human capillaries  Science Magazine · 6 days
Microcirculatory obstruction is a hallmark of severe malaria, but mechanisms of parasite sequestration are only partially understood. Here, we developed a robust three-dimensional microvessel model that... more
Ultrafast optically induced spin transfer in ferromagnetic alloys  Science Magazine · 6 days
The vision of using light to manipulate electronic and spin excitations in materials on their fundamental time and length scales requires new approaches in experiment and theory to observe and understand these... more
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