Science Magazine
Surprise! Tornadoes form from the ground up  Science Magazine · 13 hours
New data topple the long-standing theory that twisters descend from the sky more
Strengthened scientific support for the Endangerment Finding for atmospheric greenhouse gases  Science Magazine · 17 hours
We assess scientific evidence that has emerged since the U.S. Environmental Protection Agency’s 2009 Endangerment Finding for six well-mixed greenhouse gases, and find that this new... more
Synaptotagmin-3 drives AMPA receptor endocytosis, depression of synapse strength, and forgetting  Science Magazine · 17 hours
Forgetting is important. Without it, the relative importance of acquired memories in a changing environment is lost. We discovered that Synaptotagmin-3 (Syt3) localizes to post-synaptic endocytic... more
Structure of the posttranslational Sec protein-translocation channel complex from yeast  Science Magazine · 17 hours
The Sec61 protein-conducting channel mediates transport of many proteins, such as secretory proteins, across the endoplasmic reticulum (ER) membrane during or after translation. Posttranslational transport is enabled by... more
The Sommerfeld ground-wave limit for a molecule adsorbed at a surface  Science Magazine · 17 hours
Using a mid-infrared emission spectrometer based on a superconducting nanowire single-photon detector (SNSPD), we observe the dynamics of vibrational energy pooling of CO adsorbed at the... more
CRISPR-mediated activation of a promoter or enhancer rescues obesity caused by haploinsufficiency  Science Magazine · 17 hours
A wide-range of human diseases result from haploinsufficiency, where the function of one of the two gene copies is lost. Here, we targeted the... more
Neuron-specific signatures in the chromosomal connectome associated with schizophrenia risk  Science Magazine · 17 hours
To explore the developmental reorganization of the three-dimensional genome of the brain in the context of neuropsychiatric disease, we monitored chromosomal conformations in differentiating neural progenitor cells. Neuronal... more
Transcriptome and epigenome landscape of human cortical development modeled in organoids  Science Magazine · 17 hours
Genes implicated in neuropsychiatric disorders are active in human fetal brain, yet difficult to study in a longitudinal fashion. We demonstrate that organoids from human pluripotent... more
Spatiotemporal transcriptomic divergence across human and macaque brain development  Science Magazine · 17 hours
Human nervous system development is an intricate and protracted process that requires precise spatiotemporal transcriptional regulation. We generated tissue-level and single-cell transcriptomic data from up to 16 brain regions covering... more
Comprehensive functional genomic resource and integrative model for the human brain  Science Magazine · 17 hours
Despite progress in defining genetic risk for psychiatric disorders, their molecular mechanisms remain elusive. Addressing this, the PsychENCODE Consortium has generated a comprehensive online resource for... more
High-affinity allergen-specific human antibodies cloned from single IgE B cell transcriptomes  Science Magazine · 17 hours
Immunoglobulin E (IgE) antibodies protect against helminth infections but can also cause life-threatening allergic reactions. Despite their role in human health, the cells that produce these... more
Observation of the geometric phase effect in the H + HD -> H2 + D reaction  Science Magazine · 17 hours
Theory has established the importance of geometric phase (GP) effects in the adiabatic dynamics of molecular... more
3D nanofabrication by volumetric deposition and controlled shrinkage of patterned scaffolds  Science Magazine · 17 hours
Lithographic nanofabrication is often limited to successive fabrication of two-dimensional (2D) layers. We present a strategy for the direct assembly of 3D nanomaterials consisting of metals,... more
Revealing hidden spin-momentum locking in a high-temperature cuprate superconductor  Science Magazine · 17 hours
Cuprate superconductors have long been thought of as having strong electronic correlations but negligible spin-orbit coupling. Using spin- and angle-resolved photoemission spectroscopy, we discovered that one of the most studied... more
Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder  Science Magazine · 17 hours
Most genetic risk for psychiatric disease lies in regulatory regions, implicating pathogenic dysregulation of gene expression and splicing. However, comprehensive assessments of transcriptomic organization in diseased brains are limited. In... more
Genome-wide de novo risk score implicates promoter variation in autism spectrum disorder  Science Magazine · 17 hours
Whole-genome sequencing (WGS) has facilitated the first genome-wide evaluations of the contribution of de novo noncoding mutations to complex disorders. Using WGS, we identified... more
Multiproxy evidence highlights a complex evolutionary legacy of maize in South America  Science Magazine · 17 hours
Domesticated maize evolved from wild teosinte under human influences in Mexico beginning around 9000 years before the present (yr B.P.), traversed Central America by... more
Answering the Biggest Neurological Research Questions of Today
Good vibrations: Neutrons lend insight into acoustic fracking
New study says scientific basis for EPA's Endangerment Finding is stronger than ever
GPM observes heavy rainfall in intensifying Tropical Cyclone Owen
Video: Should Santa wear a flame-retardant suit?
A new algorithm improves flight safety and reduce delays
Swarming behavior discovered in fish-dwelling parasite
Five new species of sea slugs found in the ocean depths
The secret to the best seasonal hot chocolate? It's all in the chemistry!
What winter solstice rituals tell us about indigenous people