Science Magazine
A lipid-encapsulated mRNA encoding a potently neutralizing human monoclonal antibody protects against chikungunya infection  Science Magazine · 2 days
Infection with chikungunya virus (CHIKV) causes an acute illness characterized by fever, rash, and arthralgia. However, CHIKV infection can sometimes... more
B cells engineered to express pathogen-specific antibodies protect against infection  Science Magazine · 2 days
Effective vaccines inducing lifelong protection against many important infections such as respiratory syncytial virus (RSV), HIV, influenza virus, and Epstein-Barr virus (EBV) are not yet available despite decades... more
Lysostaphin and BMP-2 co-delivery reduces S. aureus infection and regenerates critical-sized segmental bone defects  Science Magazine · 2 days
Staphylococcus aureus is the most common pathogen associated with bacterial infections in orthopedic procedures. Infections often lead to implant failure... more
Unusual packing of soft-shelled nanocubes  Science Magazine · 2 days
Space-filling generally governs hard particle packing and the resulting phases and interparticle orientations. Contrastingly, hard-shaped nanoparticles with grafted soft-ligands pack differently since the energetically interacting soft-shell is amenable to nanoscale sculpturing. While the interplay between the shape and... more
Correlation between scale-invariant normal-state resistivity and superconductivity in an electron-doped cuprate  Science Magazine · 2 days
An understanding of the normal state in the high-temperature superconducting cuprates is crucial to the ultimate understanding of the long-standing problem of the origin of the... more
Engineering single-atom dynamics with electron irradiation  Science Magazine · 2 days
Atomic engineering is envisioned to involve selectively inducing the desired dynamics of single atoms and combining these steps for larger-scale assemblies. Here, we focus on the first part by surveying the single-step dynamics of graphene dopants,... more
Luminescence of coprecipitated titanium white pigments: Implications for dating modern art  Science Magazine · 2 days
Material analysis of cultural artifacts can uncover aspects of the creative process and help determine the origin and authenticity of works of art. Technical studies on... more
Selective trapping of hexagonally warped topological surface states in a triangular quantum corral  Science Magazine · 2 days
The surface of a three-dimensional topological insulator (TI) hosts two-dimensional massless Dirac fermions (DFs), the gapless and spin-helical nature of which leads... more
On-demand photonic entanglement synthesizer  Science Magazine · 2 days
Quantum information protocols require various types of entanglement, such as Einstein-Podolsky-Rosen, Greenberger-Horne-Zeilinger, and cluster states. In optics, on-demand preparation of these states has been realized by squeezed light sources, but such experiments require different optical circuits for different entangled states,... more
Angle-multiplexed all-dielectric metasurfaces for broadband molecular fingerprint retrieval  Science Magazine · 2 days
Infrared spectroscopy resolves the structure of molecules by detecting their characteristic vibrational fingerprints. Subwavelength light confinement and nanophotonic enhancement have extended the scope of this technique for monolayer studies. However, current approaches... more
Deformation of an inner valence molecular orbital in ethanol by an intense laser field  Science Magazine · 2 days
Valence molecular orbitals play a crucial role in chemical reactions. Here, we reveal that an intense laser field deforms an... more
Wearable thermoelectrics for personalized thermoregulation  Science Magazine · 2 days
Thermoregulation has substantial implications for energy consumption and human comfort and health. However, cooling technology has remained largely unchanged for more than a century and still relies on cooling the entire space regardless of the number of occupants.... more
Q&A: On a Bering Sea island, disappearing ice threatens a way of life  Science Magazine · 2 days
Opik Ahkinga hasn’t seen a good “freeze up” around the Diomede Islands since 2012 more
Nonstick chemicals that stick around and detecting ear infections with smartphones  Science Magazine · 3 days
The groundwater of Rockford, Michigan, is contaminated by per- and polyfluoroalkyl substances, chemicals found in everything from nonstick pans to dental floss to—in the case of... more
Identification of a regeneration-organizing cell in the Xenopus tail  Science Magazine · 3 days
Unlike mammals, Xenopus laevis tadpoles have a high regenerative potential. To characterize this regenerative response, we performed single-cell RNA sequencing after tail amputation. By comparing naturally occurring regeneration-competent and -incompetent... more
Hydrodealkenylative C(sp3)-C(sp2) bond fragmentation  Science Magazine · 3 days
Chemical synthesis typically relies on reactions that generate complexity through elaboration of simple starting materials. Less common are deconstructive strategies toward complexity—particularly those involving carbon-carbon bond scission. Here, we introduce one such transformation: the hydrodealkenylative cleavage of C(sp3)–C(sp2) bonds, conducted... more
Local protein synthesis is a ubiquitous feature of neuronal pre- and postsynaptic compartments  Science Magazine · 3 days
There is ample evidence for localization of messenger RNAs (mRNAs) and protein synthesis in neuronal dendrites; however, demonstrations of these processes in... more
Single-cell genomics identifies cell type-specific molecular changes in autism  Science Magazine · 3 days
Despite the clinical and genetic heterogeneity of autism, bulk gene expression studies show that changes in the neocortex of autism patients converge on common genes and pathways. However, direct assessment... more
Quantum gas microscopy of Rydberg macrodimers  Science Magazine · 3 days
The subnanoscale size of typical diatomic molecules hinders direct optical access to their constituents. Rydberg macrodimers—bound states of two highly excited Rydberg atoms—feature interatomic distances easily exceeding optical wavelengths. We report the direct microscopic observation and... more
Hierarchical reasoning by neural circuits in the frontal cortex  Science Magazine · 3 days
Humans process information hierarchically. In the presence of hierarchies, sources of failures are ambiguous. Humans resolve this ambiguity by assessing their confidence after one or more attempts. To understand the... more
Spatiotemporal light control with active metasurfaces  Science Magazine · 3 days
Optical metasurfaces have provided us with extraordinary ways to control light by spatially structuring materials. The space-time duality in Maxwell’s equations suggests that additional structuring of metasurfaces in the time domain can even further expand their... more
Constrained sialic acid donors enable selective synthesis of {alpha}-glycosides  Science Magazine · 3 days
Sialic acid is a sugar residue present in many biologically significant glycans of mammals, commonly as a terminal α-glycoside. The chemical structure of sialic acid, which features an anomeric center... more
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