Science Magazine
World Health Organization declares Ebola outbreak an international emergency  Science Magazine · 15 hours
Concern about spread in and from the Democratic Republic of the Congo propelled response more
Protein lysine de-2-hydroxyisobutyrylation by CobB in prokaryotes  Science Magazine · 19 hours
Lysine 2-hydroxyisobutyrylation (Khib) has recently been shown to be an evolutionarily conserved histone mark. Here, we report that CobB serves as a lysine de-2-hydroxyisobutyrylation enzyme that regulates glycolysis and cell growth in prokaryotes. We... more
Stabilizing the West Antarctic Ice Sheet by surface mass deposition  Science Magazine · 19 hours
There is evidence that a self-sustaining ice discharge from the West Antarctic Ice Sheet (WAIS) has started, potentially leading to its disintegration. The associated sea level rise of... more
Structural basis for the multitasking nature of the potato virus Y coat protein  Science Magazine · 19 hours
Potato virus Y (PVY) is among the most economically important plant pathogens. Using cryoelectron microscopy, we determined the near-atomic structure of PVY’s... more
Excessive exosome release is the pathogenic pathway linking a lysosomal deficiency to generalized fibrosis  Science Magazine · 19 hours
Lysosomal exocytosis is a ubiquitous process negatively regulated by neuraminidase 1 (NEU1), a sialidase mutated in the glycoprotein storage disease... more
Seasonal prediction of Indian wintertime aerosol pollution using the ocean memory effect  Science Magazine · 19 hours
As China makes every effort to control air pollution, India emerges as the world’s most polluted country, receiving worldwide attention with frequent winter (boreal)... more
Expanding the Soy Moratorium to Brazils Cerrado  Science Magazine · 19 hours
The Cerrado biome in Brazil is a tropical savanna and an important global biodiversity hot spot. Today, only a fraction of its original area remains undisturbed, and this habitat is at risk of conversion... more
The orphan nuclear receptor LRH-1/NR5a2 critically regulates T cell functions  Science Magazine · 19 hours
LRH-1 (liver receptor homolog-1/NR5a2) is an orphan nuclear receptor, which regulates glucose and lipid metabolism, as well as intestinal inflammation via the transcriptional control of intestinal glucocorticoid synthesis.... more
Photoactivation of Drosophila melanogaster cryptochrome through sequential conformational transitions  Science Magazine · 19 hours
Cryptochromes are blue-light photoreceptor proteins, which provide input to circadian clocks. The cryptochrome from Drosophila melanogaster (DmCry) modulates the degradation of Timeless and itself. It is unclear how light absorption... more
A defined antigen skin test for the diagnosis of bovine tuberculosis  Science Magazine · 19 hours
Bovine tuberculosis (bTB) is a major zoonotic disease of cattle that is endemic in much of the world, limiting livestock productivity and representing a global public... more
Worm tubes as conduits for the electrogenic microbial grid in marine sediments  Science Magazine · 19 hours
Electrogenic cable bacteria can couple spatially separated redox reaction zones in marine sediments using multicellular filaments as electron conductors. Reported as generally absent from... more
LKB1 specifies neural crest cell fates through pyruvate-alanine cycling  Science Magazine · 19 hours
Metabolic processes underlying the development of the neural crest, an embryonic population of multipotent migratory cells, are poorly understood. Here, we report that conditional ablation of the Lkb1 tumor suppressor... more
Inflammation up-regulates cochlear expression of TRPV1 to potentiate drug-induced hearing loss  Science Magazine · 19 hours
Aminoglycoside antibiotics are essential for treating life-threatening bacterial infections, despite the risk of lifelong hearing loss. Infections induce inflammation and up-regulate expression of candidate aminoglycoside-permeant cation... more
Fc receptor-like 1 intrinsically recruits c-Abl to enhance B cell activation and function  Science Magazine · 19 hours
B cell activation is regulated by the stimulatory or inhibitory co-receptors of B cell receptors (BCRs). Here, we investigated the signaling mechanism... more
Its not just how the game is played, its whether you win or lose  Science Magazine · 19 hours
Growing disparities of income and wealth have prompted extensive survey research to measure the effects on public beliefs about the... more
[Research Articles] Enhancing safety of cytomegalovirus-based vaccine vectors by engaging host intrinsic immunity  Science Magazine · 19 hours
Rhesus cytomegalovirus (RhCMV)–based vaccines maintain effector memory T cell responses (TEM) that protect ~50% of rhesus monkeys (RMs) challenged with simian immunodeficiency... more
[Focus] Diverse compositions and functions of chromatin remodeling machines in cancer  Science Magazine · 19 hours
Human cancer genetics power biochemical and functional interrogation of chromatin remodeling complexes, informing therapeutic opportunities. more
[Research Articles] Calpain 9 as a therapeutic target in TGF{beta}-induced mesenchymal transition and fibrosis  Science Magazine · 19 hours
Fibrosis is a common pathologic outcome of chronic disease resulting in the replacement of normal tissue parenchyma with a collagen-rich... more
[Research Articles] A live-attenuated RhCMV/SIV vaccine shows long-term efficacy against heterologous SIV challenge  Science Magazine · 19 hours
Previous studies have established that strain 68-1–derived rhesus cytomegalovirus (RhCMV) vectors expressing simian immunodeficiency virus (SIV) proteins (RhCMV/SIV) are able to elicit... more
[Editors' Choice] A probiotic for treating cancer  Science Magazine · 19 hours
A probiotic engineered to express a fusion of two tumor-inhibiting proteins shows targeted anticancer activity in mice. more
[Editors' Choice] A mitochondrial Pac-man drug to tackle aging  Science Magazine · 19 hours
Urolithin A, an activator of mitophagy, is safe to use and increases skeletal muscle mitochondrial gene expression in elderly individuals. more
[Research Articles] A multimodality test to guide the management of patients with a pancreatic cyst  Science Magazine · 19 hours
Pancreatic cysts are common and often pose a management dilemma, because some cysts are precancerous, whereas others have... more
Trilayer graphene shows signs of superconductivity  Science Magazine · 20 hours
Triple sheets of carbon atoms may help solve the mystery of high-temperature superconductivity more
Boosting genetic diversity may save vanishing animal populations. But it may also backfire  Science Magazine · 2 days
Long-running experiments can help conservationists plan rescues that don’t swamp small animal groups’ unique adaptations more
Arctic science at risk as University of Alaska braces for draconian budget cuts  Science Magazine · 2 days
Funding crisis could lead school to declare financial emergency and revoke tenure protections more
Hungry elephants fight climate change one mouthful at a time  Science Magazine · 3 days
The megamunchers change forest ecosystems to store more carbon over hundreds of years more
Ancient people may have used pig fat to build Stonehenge  Science Magazine · 3 days
Pottery covered in lard could have stored grease to help move the megaliths on sledges more
Topology optimization and 3D printing of multimaterial magnetic actuators and displays  Science Magazine · 6 days
Upcoming actuation systems will be required to perform multiple tightly coupled functions analogous to their natural counterparts; e.g., the ability to control displacements and high-resolution appearance... more
Distinct conducting layer edge states in two-dimensional (2D) halide perovskite  Science Magazine · 6 days
Two-dimensional (2D) lead halide perovskite with a natural "multiple quantum well" (MQW) structure has shown great potential for optoelectronic applications. Continuing advancement requires a fundamental understanding of the... more
An electrically pumped phonon-polariton laser  Science Magazine · 6 days
We report a device that provides coherent emission of phonon polaritons, a mixed state between photons and optical phonons in an ionic crystal. An electrically pumped GaInAs/AlInAs quantum cascade structure provides intersubband gain into the polariton mode at... more
Tip-enhanced strong coupling spectroscopy, imaging, and control of a single quantum emitter  Science Magazine · 6 days
Optical cavities can enhance and control light-matter interactions. This level of control has recently been extended to the nanoscale with single emitter strong coupling... more
Universal quantized thermal conductance in graphene  Science Magazine · 6 days
The universal quantization of thermal conductance provides information on a state's topological order. Recent measurements revealed that the observed value of thermal conductance of the state is inconsistent with either Pfaffian or anti-Pfaffian model, motivating several... more
Angelic halo orbit chosen for humankind’s first lunar outpost
Apollo 11 Flight Log, July 18, 1969: Entering the Moon's Gravity
Illusive patterns in math explained by ideas in physics
SpaceX Test-Fire of 'Starhopper' Starship Prototype Creates Big Fireball
Ultrasound-assisted optical imaging to replace endoscopy in breakthrough discovery
What Artemis will teach us about living, working on the moon
Flying the final approach to Tranquility Base
Crystalline 'artificial muscle' makes paper doll do sit-ups
Why women who work are less likely to develop dementia
Why the moon is such a cratered place
What is a species? The most important concept in all of biology is a complete mystery
Could humans live in lava tubes on the moon?
New measurement of universe's expansion rate is 'stuck in the middle'
New measurement of universe's expansion rate is 'stuck in the middle'
'8 Days: To the Moon and Back' Shows Apollo 11 Milestones