Pharmaceuticals
Leukemia drugs hold promise for treatment-resistant lung cancer  SCIENCE DAILY · 46 minutes
New live-cell drug discovery tool identifies two leukemia drugs and other small molecules as potential treatments for lung tumours that stopped responding to therapy. more
Electron microscopy allows scientists to understand the molecular trigger of allergic reactions  SCIENCE DAILY · 46 minutes
For the first time, researchers from the Department of Engineering and the Department of Molecular Biology and Genetics at Aarhus University have described the... more
Novartis and DNDi to partner on development of new oral treatment for visceral leishmaniasis  NEWS MEDICAL · 3 hours
Novartis and the Drugs for Neglected Diseases initiative, a not-for-profit research and development organization, have signed a collaboration and license... more
Ulcerative colitis linked to missing gut microbes  SCIENCE DAILY · 3 hours
About 1 million people in the United States have ulcerative colitis, a serious disease of the colon that has no cure and whose cause is obscure. Now, a study by Stanford University School of... more
Psychiatry: Five clearly defined patterns  SCIENCE DAILY · 4 hours
Psychiatrists have used a computer-based approach to assign psychotic patients diagnosed as bipolar or schizophrenic to five different subgroups. The method could lead to better therapies for psychoses. more
'Resetting' immune cells improves traumatic brain injury recovery in preclinical trials  SCIENCE DAILY · 4 hours
Targeting overactive immune cells and dampening their chronic neurotoxic effects may offer new therapeutic strategies for traumatic brain injury (TBI), according to new preclinical research in... more
Addicted offenders face harsher sentencing  PHYS.ORG · 5 hours
Addicted offenders are more likely to receive harsher criminal sentences than those with similar brain conditions, even when those conditions result from the use of drugs, according to a team led by University of Sussex psychologists. more
Common challenges facing drug development and reimbursement for rare diseases  NEWS MEDICAL · 5 hours
Approximately 90% of rare diseases still have no effective treatments, despite regulators implementing expedited approval pathways for these indications. more
Opioid prescription for chronic non-cancer pain increased in the last two-and-a-half decades  NEWS MEDICAL · 5 hours
The number of people with chronic non-cancer pain prescribed an opioid medicine worldwide increased in the last two-and-a-half decades. more
Olive Oil-Rich Diet May Extend Lifespan, Help Mitigate Aging-Related Diseases  SCI-NEWS.COM · 8 hours
Olive oil in the Mediterranean diet may hold the key to improving lifespan and mitigating aging-related... more
Scientists join forces to combat coronavirus outbreak  NEWS MEDICAL · 15 hours
Amid the coronavirus disease (COVID-19) outbreak, scientists from around the globe race to fight the deadly virus. Now, a team of Harvard scientists has joined forces with Chinese experts to develop new therapies and... more
A promising new oral therapy to speed up healing of broken bones  NEWS MEDICAL · 16 hours
People with diabetes are at a higher risk of fracturing a bone than the general population. And if they do break one it also... more
Small molecules may open the door to new therapies for Duchenne muscular dystrophy  NEWS MEDICAL · 17 hours
Researchers identified a group of small molecules that may open the door to developing new therapies for Duchenne muscular dystrophy, an as-yet-uncured... more
Clemson researchers discover protein function in parasites which afflict millions with diseases  NEWS MEDICAL · 17 hours
In the quest to develop more effective treatments for parasitic diseases like African sleeping sickness, Chagas disease and Leishmaniasis, scientists look for weaknesses in... more
Immunotherapy drug combination effective for patients with fast-growing neuroendocrine tumors  NEWS MEDICAL · 17 hours
Many patients with rare, fast-growing neuroendocrine tumors respond well to a common immunotherapy drug combination, according to the first peer-reviewed publication out of DART, short for Dual Anti-CTLA-4... more
Guiding nanoparticles directly to the tumor cells  NEWS MEDICAL · 19 hours
Modern anticancer therapies aim to attack tumor cells while sparing healthy tissue. An interdisciplinary team of researchers at Helmholtz-Zentrum Dresden-Rossendorf and FU Berlin has made important progress in this area: the scientists have produced... more
Scientific breakthrough provides insights into basic mechanisms of allergic reactions  NEWS MEDICAL · 21 hours
An international research team has been able to describe the overall structure of the antibody type IgE, which is the key molecule in allergic diseases. more
A highly conserved protein contributes to sensing mechanical pain, study shows  NEWS MEDICAL · 21 hours
Researchers at McGill University have discovered that a protein found in the membrane of our sensory neurons are involved in our capacity to feel mechanical pain,... more
A woman's bladder 'brewed' its own alcohol, tripping drug test  LIVE SCIENCE · 22 hours
Microbes in the woman's bladder were fermenting sugar into alcohol, causing her to test positive on a urine drug test. more
A promising new strategy to help broken bones heal faster  SCIENCE DAILY · 23 hours
To improve how broken bones heal in people with diabetes, researchers are leading work to develop an affordable oral therapy -- grown in plants. more
Researchers end decade-long search for mechanical pain sensor  SCIENCE DAILY · 23 hours
Researchers have discovered that a protein found in the membrane of our sensory neurons are involved in our capacity to feel mechanical pain, laying the foundation for the development of powerful new... more
Releasing brakes: Potential new methods for Duchenne muscular dystrophy therapies  SCIENCE DAILY · 23 hours
Testing of small molecules in mouse models for Duchenne muscular dystrophy shows promise for restoration of muscle structure and function. more
Antibodies: The body's own antidepressants  SCIENCE DAILY · 23 hours
Antibodies can be a blessing or a curse to the brain -- it all depends on their concentration. more
Directing nanoparticles straight to tumors  PHYS.ORG · 1 day
Modern anticancer therapies aim to attack tumor cells while sparing healthy tissue. An interdisciplinary team of researchers at Helmholtz-Zentrum Dresden-Rossendorf (HZDR) and FU Berlin has made important progress in this area: the scientists have produced tiny nanoparticles that... more
Researchers ID protein function in parasites that cause sometimes fatal diseases  PHYS.ORG · 1 day
In the quest to develop more effective treatments for parasitic diseases like African sleeping sickness, Chagas disease and Leishmaniasis, scientists look for weaknesses in the organisms'... more
Directing nanoparticles straight to tumors  SCIENCE DAILY · 1 day
Modern anticancer therapies aim to attack tumor cells while sparing healthy tissue. A team of researchers has now produced tiny nanoparticles that are designed to specifically target cancer cells. They can navigate directly to the tumor cells and... more
Scientists simplify access to drug building block  PHYS.ORG · 1 day
In one pot, at room temperature, chemists at Rice University are able to make valuable pharmaceutical precursors they say could change the industry. more
Programmable droplet manipulation by a magnetic-actuation robot  PHYS.ORG · 1 day
Droplet manipulation in materials science can contribute to water collection, medical diagnostics and drug delivery techniques. While structure-based liquid operations are widely used in nature and in bioinspired artificial materials, laboratory strategies depend on... more
OxyContin maker Purdue Pharma starts ad campaign for claims  ABC NEWS · 1 day
OxyContin maker Purdue Pharma is rolling out an advertising campaign to let people know they can file claims against the company over the toll of its opioids more
DNA nanostructures suit up for future missions  nanowerk · 1 day
A broadly applicable and simple chemical protection strategy removes a major roadblock in the development of therapeutic and diagnostic DNA nanostructures. more
DNA nanostructures suit up for future missions  PHYS.ORG · 1 day
Beating cancer and a plethora of other diseases does not only depend on getting hold of the right drugs—it's also about getting them to the right places in the body, while keeping damage to... more
New CRISPR base-editing technology slows ALS progression in mice  PHYS.ORG · 1 day
With a new CRISPR gene-editing methodology, scientists from the University of Illinois at Urbana-Champaign inactivated one of the genes responsible for an inherited form of amyotrophic lateral sclerosis—a debilitating and... more
Hormone blocker shocker: Drug costs 8 times more when used for kids  NEWS MEDICAL · 1 day
Dr. Sudeep Taksali, an orthopedic surgeon, became worried that his 8-year-old daughter had already grown taller than his 12-year-old son. And sometimes she had... more
Discovery may open up new avenues into improving cancer immunotherapy  NEWS MEDICAL · 2 days
New cancer immunotherapy approaches are revolutionizing treatment options for breast cancer patients. However, many lead to insufficient immune responses rendering the therapies incapable of completely eradicating tumors. more
Researchers develop new probe to detect common target of anti-inflammatory drugs  NEWS MEDICAL · 2 days
The Chan group at the Beckman Institute for Advanced Science and Technology has recently developed a probe named CoxFluor, which is able to distinguish between Cyclooxygenase-2,... more
'Scope of Nurse Anesthesia Practice' document approved by AANA Board of Directors  NEWS MEDICAL · 2 days
Meeting the demands of an ever-changing healthcare environment, the American Association of Nurse Anesthetists Board of Directors approved the updated "Scope of Nurse Anesthesia... more
Essential oil components could meet the criteria set for drug candidates  NEWS MEDICAL · 2 days
A research team at the VIB-KU Leuven Center for Microbiology and the KU Leuven Department of Biology showed that, contrary to generally held belief, most components... more
More research urgently needed on the use of antibiotics in animals  NEWS MEDICAL · 2 days
A special issue of Animal Health Research Reviews turns the spotlight on the science underlying this growing crisis - looking at the evidence base for using... more
Two new grants will help researchers to study neurotechnology, drug delivery system  NEWS MEDICAL · 3 days
Two grants will fund interdisciplinary research at the Beckman Institute for Advanced Science and Technology, including a look at how neurons and muscle cells... more
Drug cocktail holds promise for spinal injuries  SCIENCE DAILY · 4 days
Scientists have discovered a combination of two commonly available drugs that could help the body heal spinal fractures. more
Meth still a Missouri problem, but now it comes from Mexico  ABC NEWS · 4 days
Missouri may have shed its unwanted image as the meth lab capital of the U.S., but a top DEA official says the drug remains a major... more
FDA approves drug that lowers cholesterol in a new way  ABC NEWS · 4 days
U.S. regulators have approved a new type of cholesterol-lowering drug aimed at millions of people who don't get enough help from widely used statin pills like Lipitor and... more
Shaping the rings of molecules  SCIENCE DAILY · 4 days
Chemists discover a natural process to control the shape of 'macrocycles,' molecules of large rings of atoms, for use in pharmaceuticals and electronics. more
Defining the emergence of myeloid-derived suppressor cells in breast cancer using single-cell transcriptomics  Science Magazine · 4 days
Myeloid-derived suppressor cells (MDSCs) are innate immune cells that acquire the capacity to suppress adaptive immune responses during cancer. It remains elusive... more
Discovery of a picomolar potency pharmacological corrector of the mutant CFTR chloride channel  Science Magazine · 4 days
F508del, the most frequent mutation causing cystic fibrosis (CF), results in mistrafficking and premature degradation of the CFTR chloride channel. Small molecules... more
Artificial intelligence yields new antibiotic  SCIENCE DAILY · 4 days
Using a machine-learning algorithm, researchers have identified a powerful new antibiotic compound. In laboratory tests, the drug killed many of the world's most problematic disease-causing bacteria, including some strains that are resistant to all known antibiotics. It also... more
Former Iowa governor, US ag secretary to monitor drugmaker  ABC NEWS · 4 days
Former Iowa governor and U.S. Secretary of Agriculture Tom Vilsack has been hired to monitor Purdue Pharma as the OxyContin maker goes through bankruptcy more
Pill-sized 'heater' could increase accessibility in diagnosing infectious disease  SCIENCE DAILY · 4 days
Researchers have developed a tiny 'heater' -- about the size of a pill -- that could allow resource-limited regions around the world to test for infectious diseases without the need... more
Antibiotics in animals: More research urgently needed  PHYS.ORG · 4 days
A special issue of Animal Health Research Reviews turns the spotlight on the science underlying this growing crisis—looking at the evidence base for using antibiotics to prevent illness in beef and dairy cattle, swine,... more
Origins of immune system mapped, opening doors for new cancer immunotherapies  SCIENCE DAILY · 4 days
A first cell atlas of the human thymus gland could lead to new immune therapies to treat cancer and autoimmune diseases. Researchers mapped thymus tissue through... more
Therapeutic cooling effectively targets site of brain injury  SCIENCE DAILY · 4 days
Investigators successfully measure brain temperature in newborn babies undergoing therapeutic cooling, showing that the treatment effectively targets the core of the brain. more
Antidepressant harms baby neurons in lab-grown 'mini-brains'  SCIENCE DAILY · 4 days
Researchers have demonstrated the use of stem-cell-derived 'mini-brains' to detect harmful side effects of a common drug on the developing brain. Mini-brains are miniature human brain models, developed with human cells and barely visible... more
GlobalData: Oncology is top therapy area for non-industry-sponsored clinical trials  NEWS MEDICAL · 4 days
Oncology was the top therapy area for non-industry sponsored clinical trials in 2019, making up 25.7% of all clinical trials. more
Essential oil components can be tested as drug candidates  PHYS.ORG · 4 days
A research team at the VIB-KU Leuven Center for Microbiology and the KU Leuven Department of Biology showed that, contrary to generally held belief, most components of essential oils could... more
Using 'mini-brains' to detect harmful neurodevelopmental effects of antidepressant  NEWS MEDICAL · 4 days
Researchers at Johns Hopkins Bloomberg School of Public Health have demonstrated the use of stem-cell-derived "mini-brains" to detect harmful side effects of a common drug on the developing brain. more
Administering immunotherapy alongside chemoradiation for advanced NSCLC appears to be safe and tolerable  NEWS MEDICAL · 5 days
Research from Rutgers Cancer Institute of New Jersey shows administering the immunotherapy drug pembrolizumab together with chemotherapy given at the same time... more
Tulane establishes COVID-19 research program to develop a vaccine and test treatments  NEWS MEDICAL · 5 days
From working to develop one of the first nonhuman primate models for the 2019 novel coronavirus disease (COVID-19) to designing new therapeutic strategies and... more
New drug offers hope for preserving brain cells for a time after stroke  NEWS MEDICAL · 5 days
After 50 years of research and the testing of over 1,000 drugs, there is new hope for preserving brain cells for a... more
New study expands the knowledge on tumor-suppressor role of HERC proteins  NEWS MEDICAL · 5 days
The RAF protein could be a therapeutical target to treat the tumor growth in regulated pathways by the p38 protein, according to a new study published... more
Researchers develop novel therapy to combat antibiotic-resistant superbug infections  NEWS MEDICAL · 5 days
There may be a solution on the horizon to combating superbug infections resistant to antibiotics. The tenacious bacteria and fungi sicken more than 2.8 million people and lead to more... more
Macrolide, penicillin antibiotics in pregnancy could affect children’s health  NEWS MEDICAL · 5 days
A new study published in the journal BMJ in February 2020 reports that macrolide or penicillin antibiotic consumption in pregnancy could be linked to several adverse health outcomes in children.... more
Study finds racial, ethnic disparities in stroke prevention among patients undergoing dialysis  NEWS MEDICAL · 5 days
In a study of patients with kidney failure and atrial fibrillation, racial/ethnic minorities experienced higher rates of stroke compared with non-Hispanic White patients, and... more
Curing genetic disease in human cells  SCIENCE DAILY · 5 days
Scientists show for the first time that a newer type of CRISPR, called base-editing, can safely cure cystic fibrosis in stem cells derived from patients. more
Artificial Intelligence brings a novel antibiotic compound  NEWS MEDICAL · 5 days
Researchers from the Massachusetts Institute of Technology (MIT) have made a scientific breakthrough where their machine-learning algorithm or Artificial Intelligence (AI) program successfully created a novel antibiotic compound. The drug has since then been... more
Study exposes the Achilles' heel of deadly ccRCC tumors  NEWS MEDICAL · 5 days
An experimental drug already shown to be safe and help some patients with clear cell renal cell carcinoma, a deadly form of kidney cancer, effectively disables its molecular target. more
Columbia teams receive $2.1 million grant to find potential antiviral drugs for 2019-nCoV  NEWS MEDICAL · 5 days
Four research teams at Columbia University will share a $2.1 million grant to mount an aggressive effort to identify potential antiviral drugs... more
Therapeutic hypothermia effectively targets brain injury sites  NEWS MEDICAL · 5 days
When a newborn suffers lack of oxygen before or during birth, doctors have very little time to save precious brain tissue. more
Targeted combinatorial drug treatment restores beta cell function in mice  NEWS MEDICAL · 5 days
The loss of the identity of insulin-secreting beta cells in the islet of Langerhans, a process also called beta cell dedifferentiation, has been proposed to be a main... more
Researchers develop pill-sized heating device for point-of-care applications  NEWS MEDICAL · 5 days
Researchers at the University of Toronto Engineering have developed a tiny "heater" - about the size of a pill - that could allow resource-limited regions around the world to test for infectious... more
MD Anderson collaborates with Denali Therapeutics to advance novel therapies for neurodegenerative diseases  NEWS MEDICAL · 5 days
The University of Texas MD Anderson Cancer Center today announced a strategic research collaboration with Denali Therapeutics Inc. to develop novel therapies... more
The Case For Sending Drug Users Home From The Hospital With Open IV Lines.  NPR · 5 days
When patients need long-term treatment with IV antibiotics, hospitals usually let them do it at home — but not if... more
Structure of CD20 in complex with the therapeutic monoclonal antibody rituximab  Science Magazine · 5 days
Cluster of Differentiation 20 (CD20) is a B cell membrane protein that is targeted by monoclonal antibodies for the treatment of malignancies and auto-immune disorders, but... more
Molecular mechanism of biased signaling in a prototypical G protein-coupled receptor  Science Magazine · 5 days
Biased signaling, in which different ligands that bind to the same G protein–coupled receptor preferentially trigger distinct signaling pathways, holds great promise for the design of... more
Biocatalytic synthesis of planar chiral macrocycles  Science Magazine · 5 days
Macrocycles can restrict the rotation of substituents through steric repulsions, locking in conformations that provide or enhance the activities of pharmaceuticals, agrochemicals, aroma chemicals, and materials. In many cases, the arrangement of substituents in the macrocycle... more
Pill-sized 'heater' could increase accessibility in diagnosing infectious disease  PHYS.ORG · 5 days
Researchers at the University of Toronto Engineering have developed a tiny "heater"—about the size of a pill—that could allow resource-limited regions around the world to test for infectious diseases without... more
Research team tackles superbug infections with novel therapy  PHYS.ORG · 5 days
There may be a solution on the horizon to combating superbug infections resistant to antibiotics. The tenacious bacteria and fungi sicken more than 2.8 million people and lead to more than 35,000... more
Artificial intelligence yields new antibiotic  PHYS.ORG · 5 days
Using a machine-learning algorithm, MIT researchers have identified a powerful new antibiotic compound. In laboratory tests, the drug killed many of the world's most problematic disease-causing bacteria, including some strains that are resistant to all known antibiotics. It... more
Curing genetic disease in human cells  PHYS.ORG · 5 days
While the genome editing tool CRISPR/Cas9, developed in 2012, cuts a mutation out of a gene and replaces it with a gene-piece, a newer type of CRISPR, called base-editing, can repair a mutation without cutting the... more
Artificial intelligence yields new antibiotic  MIT · 5 days
A deep-learning model identifies a powerful new drug that can kill many species of antibiotic-resistant bacteria. more
Microchannel network hydrogel-induced ischemic blood perfusion connection  PHYS.ORG · 5 days
Controlled angiogenesis (growth of new blood vessels) at damaged sites is an unresolved issue in the clinical setting. Most attempts include local treatment with pro-angiogenic molecules,Jo although the approach can induce inflammatory coupling, tumorous... more
Researchers design new drug cocktail to kill brain and soft tissue cancers  NEWS MEDICAL · 5 days
Researchers at the USC Viterbi School of Engineering have designed a new drug cocktail that kills some types of brain and soft tissue cancers... more
Why the science on hazard reduction is contested  PHYS.ORG · 5 days
When it comes to reducing the extent of bushfires, scientists disagree on the best way to do it. Hazard-reduction burning (also known as "prescribed burning" or "controlled burning") is controversial and, depending... more
Patients with type 2 diabetes who decline insulin therapy had worse blood sugar control  NEWS MEDICAL · 5 days
Patients with type 2 diabetes who have high levels of blood sugar are at greater risk of serious complications such... more
Plant-based relatives of cholesterol could give boost to nanoparticle gene therapy  nanowerk · 5 days
Gene-infused nanoparticles used for combating disease work better when they include plant-based relatives of cholesterol because their shape and structure help the genes get where they... more
Trusting Injection Drug Users With IV Antibiotics At Home: It Can Work  NPR · 5 days
When patients need long-term treatment with IV antibiotics, hospitals usually let them do it at home — but not if they have a history... more
New C. elegans model will accelerate study of a rare disease  NEWS MEDICAL · 6 days
The model will permit to accelerate and reduce the price of the research, which is studying the mechanisms and the possible pharmacological targets for the neuronal... more
SwRI's Rhodium evaluates drug compounds for possible treatment of coronavirus  NEWS MEDICAL · 6 days
Drug discovery software at Southwest Research Institute is expanding the capacity to virtually screen drug compounds for possible treatment of coronavirus and other infectious diseases. more
FETO therapy produces favorable outcomes when fetal and maternal care are highly coordinated  NEWS MEDICAL · 6 days
Researchers from The Johns Hopkins Center for Fetal Therapy report new evidence that fetuses with severe congenital diaphragmatic hernia, a rare but... more
Bioengineers create light-controllable CAR T cells for cancer immunotherapy  NEWS MEDICAL · 6 days
Bioengineers at the University of California San Diego have developed a control system that could make CAR T-cell therapy safer and more powerful when treating cancer. more
Patient satisfaction and quality of life similar across all appendicitis treatments  NEWS MEDICAL · 6 days
A new study published in the journal JAMA Surgery in February 2020 shows that patients with acute appendicitis that were successfully treated either by antibiotics or... more
DuPont Nutrition & Biosciences partners with microbiome specialist MRM Health  NEWS MEDICAL · 6 days
DuPont Nutrition & Biosciences today announced a collaboration with the MRM Health NV, a biopharmaceutical company, focused on the discovery and development of innovative therapeutics based on the... more
Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation  Science Magazine · 6 days
The outbreak of a novel betacoronavirus (2019-nCoV) represents a pandemic threat that has been declared a public health emergency of international concern. The CoV spike (S) glycoprotein is... more
Diabetes over-treatment could be more dangerous for elderly find study  NEWS MEDICAL · 6 days
Diabetes, especially type 2 diabetes mellitus affects a large population across the globe. Treatment usually comprises of the use of oral drugs that could reduce the blood sugar... more
Increase in out-of-pocket costs associated with lower adherence to neurologic medications  NEWS MEDICAL · 6 days
As out-of-pocket costs go up for drugs for the neurologic disorders Alzheimer's disease, peripheral neuropathy and Parkinson's disease, people are less likely to take the drugs... more
Study uncovers factors linked with discontinuing breast cancer therapy  NEWS MEDICAL · 6 days
For women with hormone receptor-positive breast cancer, long-term endocrine therapy can greatly reduce the risk of recurrence. Many women, especially those in underserved populations, do not continue treatment, however. more
Researchers identify possible new therapy for concussion-related headaches  NEWS MEDICAL · 6 days
As she jumped to head a soccer ball during her junior year of college, Kelly Farrell collided skulls with a teammate. She later was diagnosed with a concussion, which proved to be... more
Hunt For New Coronavirus Treatments Includes Gene-Silencing And Monoclonal Antibodies  NPR · 6 days
The new coronavirus has spurred biotech labs in universities and companies to try to find new approaches to stopping the virus — from blocking its key enzymes to... more
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