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Enzyme discovery provides new horizon of therapeutic opportunities across disease spectrum
NEWS MEDICAL Doctors have long treated heart attacks, improved asthma symptoms, and cured impotence by increasing levels of a single molecule in the body: nitric oxide. 6 hours
CBT is cost-effective treatment in primary care setting, Kaiser Permanente study finds
NEWS MEDICAL Cognitive behavioral therapy delivered in a primary care setting is a cost-effective way to treat adolescents with depression who decline or quickly stop using... 6 hours
Scientists find how potential new eczema treatment could also alleviate asthma
NEWS MEDICAL Scientists from VIB-UGent have discovered insights for a possible new therapy for eczema that also reduces the severity of asthma 6 hours
Cystic fibrosis bacterial burden begins during first years of life
SCIENCE DAILY Cystic fibrosis shortens life by making the lungs prone to repeated bacterial infections and inflammation. Researchers have now shown for the first time that the lungs' bacterial population... 9 hours
Stereochemistry and amyloid inhibition: Asymmetric triplex metallohelices enantioselectively bind to A{beta} peptide
Science Magazine Stereochemistry is vital for pharmaceutical development and can determine drug efficacy. Herein, 10 pairs of asymmetric triplex metallohelix enantiomers as a library were used... 14 hours
New review explores effects of exposing developing brains to general anesthesia
NEWS MEDICAL The head of the CU School of Medicine Department of Anesthesiology has written a review of scientific studies on the potentially adverse effects of exposing developing... 15 hours
Researchers test new anti-malaria medication
NEWS MEDICAL An international research team has conducted successful phase II clinical tests of a new anti-malaria medication. The treatment led to a cure in 83 cases. 16 hours
How treating eczema could also alleviate asthma
SCIENCE DAILY Scientists have discovered insights for a possible new therapy for eczema that also reduces the severity of asthma. The findings are an important next step in understanding the relationship between the two inflammatory diseases... 18 hours
AMSBIO offers isogenic panels of neuronal iPSC derivatives
NEWS MEDICAL For several years, neuroscience research using cell line and animal models of degenerative neurological disorders such as Parkinson’s and Alzheimer’s disease has been challenged to translate results into in vivo conditions, whether... 20 hours
CE marked MAST Toxoreagent kit for detection of Toxoplasma antibodies
NEWS MEDICAL Toxoplasma gondii is an obligate, intracellular, coccidian parasite which causes toxoplasmosis in humans, a wide range of birds, mammals and reptiles worldwide. 22 hours
MAST ADATAB tablets for routine agar susceptibility testing
NEWS MEDICAL MAST ADATAB are tablets consisting of a measured dose of antibiotic which can be added to media to produce plates containing a known concentration of antibiotic. 22 hours
Not-for-profit hospitals coming up with their own generic medicines to combat shortages
NEWS MEDICAL Many of the major not-for-profit hospital groups have tried their hand an manufacturing and making generics to combat the shortages of medicines as well... 1 day
Digitization of multistep organic synthesis in reactionware for on-demand pharmaceuticals
Science Magazine Chemical manufacturing is often done at large facilities that require a sizable capital investment and then produce key compounds for a finite period. We present an approach to... 2 days
German chemical giant BASF sees 'significant' profit leap
PHYS.ORG German chemicals and pharmaceuticals giant BASF said it expects to post a 50-percent leap in net profits for 2017 on strong demand and a tax windfall due to lower levies in the... 2 days
Efficacy of antibody targeting Devic's disease proven in new animal model
SCIENCE DAILY Neuromyelitis optica (NMO) is an autoimmune disease associated with NMO immunoglobulin G (NMO-IgG). A cure for NMO remains elusive. Researchers recently established a localized NMO rat... 2 days
Default setting in electronic medical records 'nudged' emergency department physicians to limit opioid prescriptions to 10 tablets
SCIENCE DAILY For patients who have never been prescribed opioids, larger numbers of tablets given with... 2 days
Genomics reveals key macrophages' involvement in systemic sclerosis
SCIENCE DAILY A new international study has made an important discovery about the key role of macrophages, a type of immune cell, in systemic sclerosis (SSc), a chronic autoimmune disease which currently has no... 2 days
Effect of general anesthesia on developing brain
SCIENCE DAILY Scientists have reviewed scientific studies on the potentially adverse effects of exposing developing brains to general anesthesia. 2 days
New biomaterials-based system improves T-cell production
NEWS MEDICAL T cells play a key role in the body's immune response against pathogens. As a new class of therapeutic approaches, T cells are being harnessed to fight cancer, promising more precise, longer-lasting mitigation than traditional, chemical-based... 2 days
Researchers reveal potential of multivalent antibodies for HIV prevention, treatment and cure
NEWS MEDICAL The ability of HIV to mutate has been a major challenge to vaccine development. As the body produces antibodies to target the outer HIV... 2 days
Potential male birth control pill could be developed from arrow poison
NEWS MEDICAL Women have many options for oral contraceptives that are safe, effective and reversible, but despite decades of research, men have none. 2 days
Pretreatment improves outcomes in high-risk stage 3 melanoma, study shows
NEWS MEDICAL A pair of targeted therapies given before and after surgery for melanoma produced at least a six-fold increase in time to progression compared to standard-of-care surgery for patients... 2 days
Findings reveal conventional cancer therapy as double-edged sword
NEWS MEDICAL Researchers have discovered that killing cancer cells can actually have the unintended effect of fueling the proliferation of residual, living cancer cells, ultimately leading to aggressive tumor progression. 2 days
Prospective birth control pill for men has its origin in an arrow poison
SCIENCE DAILY Women have many options for oral contraceptives that are safe, effective and reversible, but despite decades of research, men have none. Now,... 2 days
Prospective birth control pill for men has its origin in an arrow poison
PHYS.ORG Women have many options for oral contraceptives that are safe, effective and reversible, but despite decades of research, men have none. Now,... 2 days
New report calls into question effectiveness of pregnancy anti-nausea drug
SCIENCE DAILY Previously unpublished information from the clinical trial that the US Food and Drug Administration relied on to approve the most commonly prescribed medicine for nausea in pregnancy indicates... 3 days
[Perspectives] Engineering precision biomaterials for personalized medicine
Science Magazine As the demand for precision medicine continues to rise, the "one-size-fits-all" approach to designing medical devices and therapies is becoming increasingly outdated. Biomaterials have considerable potential for transforming precision medicine, but individual patient complexity... 3 days
[Editors' Choice] Fighting staph: Not childs play
Science Magazine Neutralizing antibodies to Staphylococcus aureus alpha-toxin are acquired in adolescence and augmented by infection or colonization. 3 days
[Research Articles] Enhanced preclinical antitumor activity of M7824, a bifunctional fusion protein simultaneously targeting PD-L1 and TGF-{beta}
Science Magazine Antibodies targeting immune checkpoints are emerging as potent and viable cancer therapies, but not... 3 days
[Research Articles] Inhalation of peptide-loaded nanoparticles improves heart failure
Science Magazine Peptides are highly selective and efficacious for the treatment of cardiovascular and other diseases. However, it is currently not possible to administer peptides for cardiac-targeting therapy via a noninvasive procedure,... 3 days
Medical News Today: Do any weight loss pills really work?
MNT In this article, we take a look at nine types of pills and supplements that are proposed to help support weight loss, examining the evidence for each one. 3 days
Modular gene enhancer promotes leukemia and regulates effectiveness of chemotherapy
SCIENCE DAILY Every day, billions of new blood cells are generated in the bone marrow. The gene Myc is known to play an important role in this process, and is... 3 days
Secrets of longevity protein revealed in new study
SCIENCE DAILY Named after the Greek goddess who spun the thread of life, Klotho proteins play an important role in the regulation of longevity and metabolism. In a recent study, researchers revealed the three-dimensional... 3 days
Patient-derived organoids may help personalize the treatment of gastrointestinal cancers
SCIENCE DAILY A new review highlights the potential of 3-D organoid models derived from patient cells to help personalize therapy for individuals with gastrointestinal cancers. 3 days
Patients receive most opioids at the doctor's office, not the ER
SCIENCE DAILY A close examination of federal survey data shows that while many settings including ERs cut back on prescribing opioids for more than a decade, physicians' offices... 3 days
Breakthrough enables screening millions of human antibodies for new drug discovery
SCIENCE DAILY A new article outlines a pioneering method of screening a person's diverse set of antibodies for rapid therapeutic discovery. Antibody proteins are an important part of... 3 days
Breakthrough enables screening millions of human antibodies for new drug discovery
PHYS.ORG A paper just published in Nature Biotechnology outlines a pioneering method of screening a person's diverse set of antibodies for rapid therapeutic discovery. Antibody proteins are... 3 days
Uniqsis’ novel reactor system for continuous flow synthesis
NEWS MEDICAL Uniqsis reports how chemists at the School of Pharmacy, University College London (UK) have been using a FlowSyn continuous flow reactor system. 3 days
Scientists synthesize nanoparticle-antioxidants to treat strokes and spinal cord injuries
PHYS.ORG An international science team has developed an innovative therapeutic complex based on multi-layer polymer nanostructures of superoxide dismutase (SOD). The new substance can be used to effectively rehabilitate... 3 days
Researchers reveal how the MRSA bacterium handles stress
PHYS.ORG An international team of researchers has revealed a fundamental mechanism responsible for handling stress in staphylococci when they are exposed to antibiotics. It is expected that the research results can eventually be... 3 days
Bile acids: A new therapy against obesity
NEWS MEDICAL Obesity arises from an imbalance between energy intake and energy expenditure. As a result, current treatments try to decrease calorie intake and/or increase energy expenditure. 3 days
Walmart offers way to turn leftover opioids into useless gel
ABC NEWS Walmart giving pharmacy customers packet that turns leftover opioids into useless gel 3 days
Bright light therapy improves sleep in people treated for cancer
SCIENCE DAILY Results of a randomized controlled trial suggest that systematic bright light exposure can improve sleep for fatigued people who have been treated for cancer. 3 days
6-Year-Old Hallucinates After Taking Tamiflu: Why You Shouldn't Panic
LIVE SCIENCE Tamiflu can sometimes cause psychosis. You should probably still take it if your doctor prescribes it. 3 days
Pharmaceuticals and other contaminants force fish to work much harder to survive
SCIENCE DAILY Pharmaceuticals and other human-made contaminants are forcing fish that live downstream from a typical sewage treatment plant to work at least 30 percent harder... 4 days
Latvia's e-health system hit by cyberattack from abroad
PHYS.ORG Latvia said its new e-health system was on Tuesday hit by a large-scale cyberattack that saw thousands of requests for medical prescriptions pour in per second from more than 20 countries in... 4 days
Pharmaceuticals and other contaminants force fish to work much harder to survive
PHYS.ORG Pharmaceuticals and other man-made contaminants are forcing fish that live downstream from a typical sewage treatment plant to work at least 30 per cent... 4 days
New treatment target for melanoma identified
SCIENCE DAILY Researchers have identified a new therapeutic target for the treatment of melanoma. For decades, research has associated female sex and a history of previous pregnancy with better outcomes after a melanoma diagnosis. Now, a research team... 4 days
Scholars develop new technology to decode gene transcription facilitating discovery of targeted therapy drugs
PHYS.ORG A research team from the School of Chinese Medicine (SCM) of Hong Kong Baptist University (HKBU) has developed the world's... 4 days
Penn scientists identify new therapeutic target for treatment of melanoma
NEWS MEDICAL Researchers in the Perelman School of Medicine at the University of Pennsylvania have identified a new therapeutic target for the treatment of melanoma. 4 days
Research opens door to development of new treatment for type 2 diabetes
NEWS MEDICAL The team lead by Sílvia Vilares Conde, from CEDOC-NOVA Medical School, in collaboration with the pharmaceutical company Galvani Bioelectronics, demonstrated through findings in rats... 4 days
Guts of surfers more likely to be colonized by antibiotic-resistant bacteria, study reveals
NEWS MEDICAL Regular surfers and bodyboarders are three times more likely to have antibiotic resistant E. coli in their guts than non-surfers, new research... 4 days
Scientists describe groundbreaking training effect on the innate immune system
NEWS MEDICAL "Training" of precursors of white blood cells leads to a sustained positive response of the hematopoietic system. This effect could help accelerate the formation of new white blood... 4 days
Researchers use immune-mimicking biomaterial scaffolds to fast track T cell therapies
NEWS MEDICAL Immunologists and oncologists are harnessing the body's immune system to fight cancers and other diseases with adoptive cell transfer techniques. In a normal immune response, a... 4 days
Fast-tracking T-cell therapies with immune-mimicking biomaterials
SCIENCE DAILY Researchers have developed a material-based T-cell-expansion method using APC-mimetic biomaterial scaffolds, which helps achieve greater expansion of primary mouse and human T cells than existing methods. 4 days
Stop the clots, spare the coagulation
SCIENCE DAILY In the fight to cure thromboinflammatory diseases, one of the target molecules is thrombin, a protein that promotes inflammation and can cause blood clots. However, inhibiting thrombin too much can lead to uncontrolled bleeding, limiting the... 4 days
An efficient approach of conjugated tetraenes from butadiene and alkynes
SCIENCE DAILY Conjugated tetraenes are important key substructures in electronic materials, natural products and pharmaceutical molecules. However, they are difficult to synthesize. Now, researchers in Japan have achieved a new... 4 days
Surfers more likely to get antibiotic resistant E. coli in their guts
NEWS MEDICAL A new study has found that surfers and body boarders are more likely to get antibiotic resistant Escherichia coli (E. coli) in their guts... 4 days
Biomaterials with 'logic gates' release therapeutics in response to environmental triggers
SCIENCE DAILY Scientists have announced that they have built and tested a new biomaterial-based delivery system -- known as a hydrogel -- that will encase a desired cargo... 5 days
Surfers three times more likely to have antibiotic-resistant bacteria in guts
SCIENCE DAILY Scientists compared fecal samples from surfers and non-surfers to assess whether the surfers' guts contained E. coli bacteria that were able to grow in the presence... 5 days
CVS Pharmacy promises to end touchups of its beauty images
ABC NEWS Pharmacy giant CVS says it has a responsibility to think about sending messages of unrealistic body images to girls and young women and will stop significant touchups of... 5 days
Fast-tracking T cell therapies with immune-mimicking biomaterials
PHYS.ORG Immunologists and oncologists are harnessing the body's immune system to fight cancers and other diseases with adoptive cell transfer techniques. In a normal immune response, a type of white blood cell known as T... 5 days
Researchers program biomaterials with 'logic gates' that release therapeutics in response to environmental triggers
PHYS.ORG Drug treatments can save lives, but sometimes they also carry unintended costs. After all, the same therapeutics that target pathogens... 5 days
Administration of Two Proteins Shown to Counteract Neurodegeneration in Parkinson's Disease
NEWS MEDICAL A combination therapy made up of two neurotrophic factors can reduce the degenerative effects of Parkinson’s disease, shows new research. 5 days
Researchers Find Administration of Two Proteins Has Regenerating Effect in Model of Parkinson's Disease
NEWS MEDICAL A combination therapy made up of two neurotrophic factors can reduce the degenerative effects of Parkinson’s disease, shows new research. 5 days
Subtle changes in chemical structure can affect drug toxicity
PHYS.ORG NUS pharmaceutical scientists have discovered the mechanisms involved when small chemical modifications to certain pharmaceutical drugs may cause harm instead of improving treatment. 5 days
An efficient approach of conjugated tetraenes from butadiene and alkynes
PHYS.ORG Conjugated tetraenes are important key substructures in electronic materials, natural products and pharmaceutical molecules. However, they are difficult to synthesize. They are conventionally prepared by repetitions of the... 5 days
Study identifies mechanisms underlying glucose-induced peripheral neuropathy
NEWS MEDICAL New research by MDI Biological Laboratory scientist Sandra Rieger, Ph.D., and her team has demonstrated that an enzyme she had previously identified as playing a role in peripheral neuropathy induced by cancer chemotherapy also... 1 week
Synergy between two neurotrophic factors exerts beneficial effect in early phase of Parkinson’s disease
NEWS MEDICAL Parkinson's disease is currently the second most widespread neurogenerative pathology. Current therapies are mainly of a replacement type and pose... 1 week
Global study on stroke prevention in high-risk AF patients
NEWS MEDICAL The largest global clinical study on the best-possible therapy for patients with atrial fibrillation at high risk of having a stroke and at increased risk of bleeding is starting at... 1 week
Genetic analysis can improve depression therapy
SCIENCE DAILY The failure of SSRI antidepressants can be a result of genetic variations in patients. Variations within the gene that encodes the CYP2C19 enzyme results in extreme differences in the levels of escitalopram achieved in patients, according... 1 week
The combination of two proteins exerts a regenerating effect in Parkinson's disease
SCIENCE DAILY Current therapies for Parkinson's disease are mainly of a replacement type and pose problems in the long term, so the challenge is to establish... 1 week
New biomarkers for colorectal cancer
SCIENCE DAILY Researchers have found a new biomarker for colorectal cancer (CRC) that might improve therapy and survival rates of patients. Biomarkers are measurable biological indicators for a specific disease, such as changes in the amounts of certain proteins that... 1 week
Glucose-induced nerve damage: Research identifies underlying mechanisms
SCIENCE DAILY New research has demonstrated that an enzyme she had previously identified as playing a role in peripheral neuropathy induced by cancer chemotherapy also plays a role in peripheral neuropathy caused by diabetes. The significance... 1 week
Scientists make cells that enable the sense of touch
SCIENCE DAILY Researchers have, for the first time, coaxed human stem cells to become sensory interneurons -- the cells that give us our sense of touch. The new protocol could be a... 1 week
Re-programming innate immune cells to fight tuberculosis
SCIENCE DAILY Tuberculosis (TB), an infectious disease which attacks the lungs, claims someone's life every 20 seconds and 1.5 million lives worldwide every year. A cure has eluded scientists for more than a century but, now,... 1 week
WATCH: Many pregnant women are being prescribed potentially dangerous antibiotics: CDC
ABC NEWS CDC researchers studied almost 500,000 privately insured pregnant women in 2014 and found that about 70 percent of women in the first trimester received antibiotics for... 1 week
New analysis highlights need for protective therapy to reduce risk of repeat heart attacks
NEWS MEDICAL AstraZeneca announced today the publication of a new analysis from an ongoing real-world quality registry that suggests the risk of... 1 week
The Latest: Judge invites states to discuss opioid crisis
ABC NEWS A federal judge who's overseeing lawsuits from around the country against the pharmaceutical industry has invited Ohio's attorney general to brief him on the impact of the opioid epidemic in... 1 week
Federal judge invites states to discuss opioid crisis
ABC NEWS A federal judge who's overseeing lawsuits from around the country against the pharmaceutical industry has invited state attorneys general to join discussions and provide input 1 week
Scientists make cells that enable the sense of touch
PHYS.ORG Researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have, for the first time, coaxed human stem cells to become sensory interneurons—the... 1 week
Gene therapy: The power of persistence
Science Magazine 1 week
Gene therapy comes of age
Science Magazine After almost 30 years of promise tempered by setbacks, gene therapies are rapidly becoming a critical component of the therapeutic armamentarium for a variety of inherited and acquired human diseases. Gene therapies for inherited immune disorders, hemophilia, eye... 1 week
Researchers report first 3-D structure of DHHC enzymes
PHYS.ORG The first three-dimensional structure of DHHC proteins—enzymes involved in many cellular processes, including cancer—explains how they function and may offer a blueprint for designing therapeutic drugs. Researchers have proposed blocking DHHC activity... 1 week
Cross-sex hormone therapy may improve eating disorder symptoms in transgender people
NEWS MEDICAL New research has shown that receiving cross-sex hormone therapy (CHT) can help to reduce the feelings of body dissatisfaction associated with eating disorders including anorexia and... 1 week
Judge invites Ohio attorney general to discuss opioid crisis
ABC NEWS A federal judge who's overseeing lawsuits from around the country against the pharmaceutical industry has invited Ohio's attorney general to brief him on the impact of the opioid epidemic in... 1 week
Metabolic Syndrome could make it harder for older adults to respond to antidepressant therapy
NEWS MEDICAL Researchers suspect that having Metabolic Syndrome makes it harder for older adults to respond to therapies for depression. 1 week
Researchers discover new promising biomarker for colorectal cancer
NEWS MEDICAL Researchers from the University of Luxembourg found a new biomarker for colorectal cancer (CRC) that might improve therapy and survival rates of patients. 1 week
Tracking protein disposal could lead to improved therapies
PHYS.ORG Northwestern Medicine investigators developed a technique to catalog how cells dispose of unnecessary proteins, a process that has implications for cancer and autism-spectrum diseases, according to findings published in Nature Communications. 1 week
Researchers create ‘protocells’ for delivering drugs to deepest tumor regions
NEWS MEDICAL Despite herculean efforts, cancer remains a formidable disease, with each malignant subtype responding differently to therapeutics. 1 week
Pfizer to stop Alzheimer’s and Parkinson’s disease research
NEWS MEDICAL Pharmaceutical giant Pfizer has announced its intention to stop research and development in areas including Alzheimer’s disease and Parkinson’s disease. 1 week
Decorated cardiac stem cells could provide enhanced treatment for heart attacks
NEWS MEDICAL Although cardiac stem cell therapy is a promising treatment for heart attack patients, directing the cells to the site of an injury - and getting them... 1 week
Tiny antibiotic beads fight infections after joint replacement
SCIENCE DAILY More than 1 million people undergo total joint replacements each year, and nearly 10,000 will develop infections. To reduce this infection risk, an orthopedic surgeon created small antibiotic beads that are implanted... 1 week
[Editors' Choice] Gold photothermal therapy: A positive for negative margins
Science Magazine Nanoparticle-based photothermal therapy after tumor resection inhibits recurrence. 1 week
[Editors' Choice] Factoring in new gene therapy treatments for hemophilia A
Science Magazine Delivery of a modified factor VIII gene leads to dramatic improvement of severe hemophilia A in human trials. 1 week
[Editors' Choice] Rapid drug screen using 3D tumor organoids
Science Magazine Breast cancer organoids enable high-throughput functional drug screens to potentially guide individualized therapy. 1 week
Medical News Today: HIV could be treated with a once-a-week pill
MNT Researchers have created a capsule able to deliver 1 week's worth of HIV drugs in one dose, which offers a much simpler treatment regimen for patients. 1 week
Biomarkers may help predict prognosis of gastric cancer patients with alcohol consumption habits
NEWS MEDICAL Alcohol consumption has been identified as a modifiable risk factor for cancers such as gastric cancer. A new report in the The... 1 week
Impact of craniosacral therapy on concussion and mild TBI symptoms among football players
NEWS MEDICAL This invited commentary references a preliminary study in which the integrative medicine technique known as CranioSacral Therapy was tested on a group... 1 week
Deciphering Antibodies with Next-Generation Protein Sequencing Technology
NEWS MEDICAL
Gut Check: Gas-Sniffing Capsule Charts The Digestive Tract
NPR