Taking advantage of powerful advances in CRISPR gene editing, scientists at the University of California San Diego have set their sights on one of society's most formidable threats to human health.... PHYS.ORG · 6 months
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We discuss the impact of antibiotic-resistant infections on everyday life and the work that is being done to overcome this issue with Antibiotic Research UK. more
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Poison is lethal all on its own -- as are arrows -- and together, they can take down the strongest opponents. A team of Princeton researchers have found an antibiotic that simultaneously punctures bacterial walls and destroys folate... more
CRISPR-Cas12a delivery by DNA-mediated bioresponsive editing for cholesterol regulation  Science Magazine · 2 weeks
CRISPR-Cas12a represents an efficient tool for genome editing in addition to the extensively investigated CRISPR-Cas9. However, development of efficient nonviral delivery system for CRISPR-Cas12a remains challenging. Here, we demonstrate a... more
Brief animated video effective in spreading the word about antibiotic risks  NEWS MEDICAL · 8 hours
Antibiotics are important drugs that can save lives, but using them too often can lead to dangerous strains of antibiotic-resistant bacteria. New Penn State research explores... more
Researchers develop 'poisoned arrow' to defeat antibiotic-resistant bacteria  PHYS.ORG · 17 hours
Poison is lethal all on its own—as are arrows—but their combination is greater than the sum of their parts. A weapon that simultaneously attacks from within and without can take down even... more
Harvard’s Wyss Institute joins forces with Cytosurge to improve CRISPR-based multiplexed gene editing  NEWS MEDICAL · 4 weeks
Today, the Wyss Institute for Biologically Inspired Engineering at Harvard University and Cytosurge AG, a company manufacturing unique high-precision nanotechnology instruments, announced... more
CRISPR a tool for conservation, not just gene editing  PHYS.ORG · 2 weeks
The gene-editing technology CRISPR has been used for a variety of agricultural and public health purposes—from growing disease-resistant crops to, more recently, a diagnostic test for the virus that causes... more
CRISPR a tool for conservation, not just gene editing  SCIENCE DAILY · 2 weeks
The gene-editing technology CRISPR has been used for a variety of agricultural and public health purposes -- from growing disease-resistant crops to, more recently, a diagnostic test for the virus... more
Taming CRISPR's collateral damage  PHYS.ORG · 1 week
CRISPR-Cas9 can alter genes at pre-defined sites in specific ways, but it does not always act as planned. An LMU team has now developed a simple method to detect unintended "on-target" events, and shown that they often occur in human... more
Engineering natural selection in microbes has implications for biofuel production, addressing antibiotic resistance  PHYS.ORG · 4 weeks
Scientists who study adaptation—or edit the genes of organisms—know the limitations inherent in conventional approaches to mutation that offer little opportunity to... more
A phage-encoded anti-CRISPR enables complete evasion of type VI-A CRISPR-Cas immunity  Science Magazine · 7 days
The crRNA-guided nuclease Cas13 recognizes complementary viral transcripts to trigger the degradation of both host and viral RNA during the type VI CRISPR-Cas antiviral response. How... more
Programming PAM antennae for efficient CRISPR-Cas9 DNA editing  Science Magazine · 4 weeks
Bacterial CRISPR-Cas9 nucleases have been repurposed as powerful genome editing tools. Whereas engineering guide RNAs or Cas nucleases have proven to improve the efficiency of CRISPR editing, modulation of protospacer-adjacent motif (PAM),... more
Nature-inspired CRISPR enzymes for expansive genome editing  PHYS.ORG · 2 weeks
In nature, bacteria use CRISPR as an adaptive immune system to protect themselves against viruses. Over the past decade, scientists have been able to successfully build upon that natural phenomenon with the discovery of... more
Exchange of arms between chromosomes using molecular scissors  SCIENCE DAILY · 7 days
The CRISPR/Cas molecular scissors work like a fine surgical instrument and can be used to modify genetic information in plants. Research teams have now not only exchanged single genes, but recombined entire... more
Antibiotic-destroying genes widespread in bacteria in soil and on people  PHYS.ORG · 1 day
The latest generation of tetracyclines—a class of powerful, first-line antibiotics—was designed to thwart the two most common ways bacteria resist such drugs. But a new study from researchers... more
New advance addresses a big challenge with using CRISPR in cancer patients  NEWS MEDICAL · 1 day
A mutation unique to certain cancer tumors is a potential homing beacon for safely deploying CRISPR gene editing enzymes to disarm DNA that makes... more
Researchers tap CRISPR technology to connect biology, electronics  PHYS.ORG · 2 weeks
In an effort to create first-of-kind microelectronic devices that connect with biological systems, University of Maryland (UMD) researchers are utilizing CRISPR technology in a novel way to electronically turn "on" and "off"... more
Genome-based monitoring of multi-resistant pathogen can help improve infection control  NEWS MEDICAL · 3 weeks
S. maltophilia strains occur in several natural and human associated ecosystems. The bacterium was long regarded as relatively unproblematic but is now considered to be one of the... more
Antibiotic-destroying genes widespread in bacteria in soil and on people  SCIENCE DAILY · 1 day
Researchers have found that genes that confer the power to destroy tetracycline antibiotics are widespread in bacteria. But the researchers have also created a chemical compound that shields... more
Mimicking nature's best medicine opens door to new treatments  PHYS.ORG · 3 weeks
Discoveries made by a University of Canterbury (UC) organic chemist could be a springboard to new treatments for cancers and antibiotic resistant infections. more
Genetic tradeoffs do not stop evolution of antibiotic resistance  PHYS.ORG · 2 weeks
Bacteria can still develop antibiotic resistance even in the face of challenging genetic tradeoffs, or compromises, associated with varying antibiotic concentrations, says a new study published today in eLife. more
Tracking an organism's development, cell by cell  PHYS.ORG · 3 weeks
Scientists at the Stem Cell Research program at Boston Children's Hospital and Dana-Farber Cancer Institute/Harvard Medical School have devised a mouse model that lets researchers track every cell in the body, from the embryonic... more
[Editors' Choice] Following the rules to foil Gram-negative infections  Science Magazine · 13 hours
Molecular design principles increase accumulation of an antibiotic in multidrug resistant Gram-negative bacteria. more
SHERLOCK-based one-step test provides rapid and sensitive Covid-19 detection  MIT · 4 weeks
New CRISPR-based research tool delivers results in an hour; researchers share protocol and kits to advance research and move toward clinical validation. more
Bacteria that live in soil and on people have extensive antibiotic-destroying genes  NEWS MEDICAL · 1 day
The latest generation of tetracyclines - a class of powerful, first-line antibiotics - was designed to thwart the two most common ways bacteria resist... more
Editing plant chromosomes using molecular scissors  PHYS.ORG · 1 week
The CRISPR/Cas molecular scissors work like a fine surgical instrument and can be used to modify genetic information in plants. The research teams of Professor Holger Puchta of Karlsruhe Institute of Technology (KIT) and Professor Andreas... more
Researchers discover a combination punch to treat drug-resistant infections  NEWS MEDICAL · 3 weeks
McMaster University researchers have discovered a combination punch to treat drug-resistant infections that is showing promise based on testing in mice. more
Nature-inspired CRISPR enzymes for expansive genome editing  MIT · 2 weeks
Applied computational biology discoveries vastly expand the range of CRISPR’s access to DNA sequences. more
Scientists identify compounds in noxious weed that reduce virulence of Staphylococcus bacteria  NEWS MEDICAL · 2 weeks
Scientists have identified specific compounds from the Brazilian Peppertree -- a weedy, invasive shrub in Florida -- that reduce the virulence of antibiotic-resistant staph... more
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