Scientists of Ludwig-Maximilians-Universitaet (LMU) in Munich have developed a tool to eliminate essential proteins from cells with a flash of light. The new method makes it possible to study the function of essential proteins.... PHYS.ORG · 1 month
How cellular machinery labels proteins for degradation  PHYS.ORG · 1 week
Proteins are molecular work horses in the cell that perform specific tasks, but it is essential that the timing of protein activities is exquisitely controlled. When proteins have fulfilled their tasks, their degradation ends... more
PHOTACs enable optical control of protein degradation  Science Magazine · 2 days
PROTACs (PROteolysis TArgeting Chimeras) are bifunctional molecules that target proteins for ubiquitylation by an E3 ligase complex and subsequent degradation by the proteasome. They have emerged as powerful tools to control the levels of... more
Putting a finger on plant stress response  PHYS.ORG · 3 weeks
Post-translational modification is the process whereby proteins are modified after their initial biosynthesis. Modification can take many forms, including enzymatic cleavage of the protein or the addition of sugars, lipids, or small chemical groups.... more
'Levitating' proteins could help diagnose opioid abuse, other diseases  PHYS.ORG · 3 weeks
Researchers at Michigan State University's Precision Health Program have helped develop a fascinating new method for detecting the density of proteins in the blood—a method that could vastly improve the... more
Researchers discover how cells clear misfolded proteins from tissues  PHYS.ORG · 5 days
Researchers in Japan have identified a new quality control system that allows cells to remove damaged and potentially toxic proteins from their surroundings. The study, which will be published February... more
Magnetically levitated plasma proteins could vastly improve diagnosis of diseases  NEWS MEDICAL · 3 weeks
Researchers at Michigan State University's Precision Health Program have helped develop a fascinating new method for detecting the density of proteins in the blood - a method that... more
How to halt the global decline of lands  PHYS.ORG · 2 weeks
Land degradation—the reduction in the capacity of the land to support human and other life on Earth—is one of the humanity's biggest challenges. Yet, little is being done to slow down or... more
Noncontact catalysis: Initiation of selective ethylbenzene oxidation by Au cluster-facilitated cyclooctene epoxidation  Science Magazine · 3 weeks
Traditionally, a catalyst functions by direct interaction with reactants. In a new noncontact catalytic system (NCCS), an intermediate produced by one catalytic reaction serves... more
Superfast insights into cellular events  PHYS.ORG · 4 weeks
In the same way that a single piece of a puzzle fits into the whole, the molecule hypoxanthine binds to a ribonucleic acid (RNA) chain, which then changes its three-dimensional shape within a second and in so doing... more
Study uncovers molecular mechanism that triggers a rare type of muscular dystrophy  NEWS MEDICAL · 4 weeks
A study led by the IBB-UAB has identified the molecular mechanism through which a protein, when carrying genetic mutations associated with a rare disease... more
Autophagy degrades liquid droplets—but not aggregates—of proteins  PHYS.ORG · 1 week
Under JST's Strategic Basic Research Programs, Noda Nobuo and Yamasaki Akinori at the Institute of Microbial Chemistry, in collaboration with other researchers, have discovered that autophagy is effective for selectively degrading protein in a... more
Using neutrons and X-rays to analyze the aging of lithium batteries  SCIENCE DAILY · 2 weeks
An international team has used neutron and X-ray tomography to investigate the dynamic processes that lead to capacity degradation at the electrodes in lithium batteries. Using... more
Machine learning technique speeds up crystal structure determination  PHYS.ORG · 3 weeks
Nanoengineers at the University of California San Diego have developed a computer-based method that could make it less labor-intensive to determine the crystal structures of various materials and molecules, including alloys, proteins... more
Collaboration lets researchers 'read' proteins for new properties  PHYS.ORG · 2 weeks
Clumps of proteins inside cells are a common thread in many neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) or Lou Gehrig's disease. These clumps, or solid aggregates of proteins, appear to be... more
Active particles as mobile microelectrodes for selective bacteria electroporation and transport  Science Magazine · 4 weeks
Self-propelling micromotors are emerging as a promising micro- and nanoscale tool for single-cell analysis. We have recently shown that the field gradients necessary to manipulate matter... more
Scientists can now design new proteins from scratch with specific functions  PHYS.ORG · 2 weeks
Proteins are the molecular machines that make all living things hum—they stop deadly infections, heal cells and capture energy from the sun. Yet because our basic... more
Technique can label many specific DNAs, RNAs, or proteins in a single tissue sample  PHYS.ORG · 5 days
A new technique can label diverse molecules and amplify the signal to help researchers spot those that are especially rare.... more
Caught soap-handed: Understanding how soap molecules help proteins get in and out of shape  PHYS.ORG · 2 weeks
Understanding the interactions between proteins and soap molecules (surfactants) has long been important for the industry, particularly within detergents and... more
Machine learning technique speeds up crystal structure determination  nanowerk · 3 weeks
Nanoengineers have developed a computer-based method that could make it less labor-intensive to determine the crystal structures of various materials and molecules, including alloys, proteins and pharmaceuticals. more
Researchers discover new genetic drivers of cancer  NEWS MEDICAL · 2 weeks
The discovery of genetic drivers of cancer can have critical implications for the diagnosis and treatment of cancer patients, yet genome analysis has focused primarily on only 1-2% of the whole genome - the... more
Detecting diseases with magnetically levitated plasma proteins  nanowerk · 3 weeks
Proteins present in human plasma mirror a person's physiology and the ability to rapidly profile the plasma proteome holds the promise of a revolution in point-of-care disease diagnosis and therapeutic monitoring. New research findings... more
Observing proteins in their natural environment  PHYS.ORG · 2 weeks
Proteins can be responsible for the fact that the active ingredients of drugs are simply released from the target cells. You can watch them do this now. more
Breaking through computational barriers to create designer proteins  nanowerk · 3 weeks
This work provides a path forward for one to computationally design specific, programmable binding into proteins, previously a property only found in the DNA and RNA world. more
Stanford scientists complete first global census of cell surface proteins  NEWS MEDICAL · 4 weeks
Stanford scientists have completed the first global census of diverse proteins sprouting tree-like from the outer membrane of a cell. These cell surface proteins govern how cells interact... more
Pro EZLC method translator simplifies LC method migration  NEWS MEDICAL · 2 weeks
Scaling down an existing LC method to a smaller column format can speed up run time, increase sample throughput, and reduce solvent use, but only if the LC conditions are also properly... more
Mathematician develops method to explore the structure of molecules  PHYS.ORG · 3 weeks
A scientist from the Mathematical Laboratory of RUDN University has obtained new results in a study of the inverse problem for coupled Schrödinger equations. This result will be useful for... more
Analysis of human genomes in the cloud  PHYS.ORG · 2 weeks
Most bioinformatics software used for genomic analysis is experimental in nature and has a relatively high failure rate. In addition, cloud infrastructure itself, when run at scale, is prone to system crashes. These setbacks... more
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