Using a targeted gene epigenome editing approach in the developing mouse brain, researchers reversed one gene mutation that leads to the genetic disorder WAGR syndrome, which causes intellectual disability and obesity in people. This specific editing was unique in that it changed the epigenome -- how the genes are regulated -- without changing the actual genetic code of the gene being regulated.... SCIENCE DAILY · 6 months
New technique opens the door to treating genetic forms of hearing loss  NEWS MEDICAL · 5 hours
Using a new genetic engineering technique, known as base editing, researchers from Boston Children's Hospital and the Broad Institute of MIT and Harvard, have... more
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Researchers discover new gene involved in regulating the body's cholesterol  NEWS MEDICAL · 1 month
Precision medicine has the potential to tailor treatments to a patient's unique genetic sequence. But achieving this precision -- or developing new drugs -- requires knowing which genes... more
A promise to restore hearing  SCIENCE DAILY · 12 hours
For the first time, researchers have used base editing to restore partial hearing to mice with a recessive mutation in the gene TMC1 that causes complete deafness, the first successful example of genome editing to fix a recessive... more
Repurposed drug normalizes body weight, reverses metabolic damage in obese mice  NEWS MEDICAL · 3 weeks
An off-label experiment in mice using disulfiram, which has been used to treat alcohol use disorder for more than 50 years, consistently normalized body weight and... more
See a 3D mouse brain with single-cell resolution  SCIENCE DAILY · 4 weeks
A manually constructed 3D atlas offers a cellular-level view of the entire mouse brain. This reference brain, called the Allen Mouse Brain Common Coordinate Framework (CCFv3), is derived from serial two-photon tomography... more
How does the brain link events to form a memory? Study reveals unexpected mental processes  SCIENCE DAILY · 4 weeks
The brain has a powerful ability to remember and connect events separated in time. And now, in a... more
Genetic variation in a brain-cleansing water channel affects human sleep  SCIENCE DAILY · 4 weeks
The reason why we sleep remains an unresolved question of the 21st century. Research now shows that the depth of non-rapid-eye-movement (nonREM) sleep in humans is associated with... more
Scientists discover the 'brain's steering wheel' that controls mice’s movements  NEWS MEDICAL · 3 weeks
Walking is one of the most important motor skills for animals and humans. And for almost all people, being able to walk is deeply essential. In spite of... more
Genomic analysis in samples of Neanderthals and modern humans shows a decrease in ADHD-associated genetic variants  SCIENCE DAILY · 1 week
The frequency of genetic variants associated with attention-deficit/hyperactivity disorder (ADHD) has decreased progressively in the evolutionary... more
Lipid metabolism controls brain development  SCIENCE DAILY · 4 weeks
A lipid metabolism enzyme controls brain stem cell activity and lifelong brain development. If the enzyme does not work correctly, it causes learning and memory deficits in humans and mice, as researchers have discovered. Regulating stem cell activity... more
Breakthrough discovery could lead to treatment of Fragile X syndrome  NEWS MEDICAL · 1 day
Scientists at the Hotchkiss Brain Institute, Alberta Children's Hospital Research Institute, and Owerko Centre at UCalgary's Cumming School of Medicine have made a breakthrough discovery that could lead... more
Scientists find brain center that 'profoundly' shuts down pain  SCIENCE DAILY · 2 weeks
A research team has found a small area of the brain in mice that can profoundly control the animals' sense of pain. Somewhat unexpectedly, this brain center turns pain off,... more
Genomic analysis compares ADHD-related genetic variants in Neanderthal and modern human samples  NEWS MEDICAL · 1 week
The frequency of genetic variants associated with attention-deficit/hyperactivity disorder (ADHD) has decreased progressively in the evolutionary human lineage from the Palaeolithic to nowadays, according... more
Using brain imaging to demonstrate weaker neural suppression for those with autism  SCIENCE DAILY · 5 days
A new study shows the differences in visual motion perception in autism spectrum disorder are accompanied by weaker neural suppression in the visual cortex... more
Scientists identify gene linked to thinness that may help resist weight gain  SCIENCE DAILY · 2 weeks
Researchers used a genetic database of more than 47,000 people in Estonia to identify a gene linked to thinness that may play a role... more
Low proportion of individuals with autism receive recommended genetic tests, study finds  SCIENCE DAILY · 3 weeks
A new study found that only 3 percent of individuals diagnosed with autism spectrum disorder reported having fully received clinical genetic tests recommended by... more
Lipid metabolism controls brain development  PHYS.ORG · 4 weeks
Neural stem cells are not only responsible for early brain development—they remain active for an entire lifetime. They divide and continually generate new nerve cells and enable the brain to constantly adapt to new demands. Various genetic mutations... more
Editing selfies is counter productive  SCIENCE DAILY · 4 weeks
Girls and young women shouldn't spend a lot of time editing selfies for social media because it negatively influences their thoughts about their looks, according to a new publication. more
How experiencing traumatic stress leads to aggression  SCIENCE DAILY · 2 weeks
Traumatic stress can cause aggression by strengthening two brain pathways involved in emotion, according to new research. Targeting those pathways via deep brain stimulation may stymie aggression associated with post-traumatic stress disorder. more
Only 3% individuals diagnosed with autism receive recommended clinical genetic tests  NEWS MEDICAL · 3 weeks
A study analyzing data from the Rhode Island Consortium for Autism Research and Treatment (RI-CART) found that only 3% of individuals diagnosed with autism spectrum disorder... more
Disordered gut microbiomes are found in patients with hemorrhagic brain disease  NEWS MEDICAL · 1 week
A new study shows that people with a rare genetic disease that causes bleeding in the brain have gut microbiomes distinct from those without the disease. more
Harvard’s Wyss Institute joins forces with Cytosurge to improve CRISPR-based multiplexed gene editing  NEWS MEDICAL · 4 weeks
Today, the Wyss Institute for Biologically Inspired Engineering at Harvard University and Cytosurge AG, a company manufacturing unique high-precision nanotechnology instruments, announced... more
Programming PAM antennae for efficient CRISPR-Cas9 DNA editing  Science Magazine · 4 weeks
Bacterial CRISPR-Cas9 nucleases have been repurposed as powerful genome editing tools. Whereas engineering guide RNAs or Cas nucleases have proven to improve the efficiency of CRISPR editing, modulation of protospacer-adjacent motif (PAM),... more
CRISPR a tool for conservation, not just gene editing  PHYS.ORG · 2 weeks
The gene-editing technology CRISPR has been used for a variety of agricultural and public health purposes—from growing disease-resistant crops to, more recently, a diagnostic test for the virus that causes... more
Family environment affects adolescent brain development  SCIENCE DAILY · 2 weeks
Childhood environment and socioeconomic status affect cognitive ability and brain development during adolescence independently of genetic factors, researchers report. The study demonstrates how important the family environment is, not just during early infancy but also throughout... more
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