DJ-1 is well known as an important target for the treatment of a number of diseases such as Parkinson's disease. Cantabio has been developing novel small molecule therapeutic program targeting the DJ-1 protein with a focus on Parkinson's and also exploring a number of other disease areas.... NEWS MEDICAL · 3 weeks
Resolution metabolomes activated by hypoxic environment  Science Magazine · 3 weeks
Targeting hypoxia-sensitive pathways in immune cells is of interest in treating diseases. Here, we demonstrate that physiologic hypoxia (1% O2), as encountered in bone marrow and spleen, accelerates human M2 macrophage efferocytosis of apoptotic-neutrophils and senescent... more
A new material for regenerative medicine capable of controlling cell immune response  PHYS.ORG · 2 weeks
Scientists at Tomsk Polytechnic University jointly with the University of Montana (USA) proposed a promising new material for regenerative medicine for recovery of damaged... more
How hot (and not-so-hot) compounds in chili peppers change during ripening  SCIENCE DAILY · 5 days
Anyone who has tasted a hot chili pepper has felt the burn of capsaicinoids, the compounds that give peppers their spiciness, as well as possible health... more
Targeting inflammatory sites through collagen affinity enhances the therapeutic efficacy of anti-inflammatory antibodies  Science Magazine · 6 days
Enhancing the therapeutic efficacy of drugs for inflammatory diseases is of high demand. One possible approach is targeting drugs to the extracellular... more
How hot (and not-so-hot) compounds in chili peppers change during ripening  PHYS.ORG · 6 days
Anyone who has tasted a hot chili pepper has felt the burn of capsaicinoids, the compounds that give peppers their spiciness, as well as possible health... more
Scientists find molecular key to body making healthy T cells  SCIENCE DAILY · 3 weeks
In a finding that could help lead to new therapies for immune diseases like multiple sclerosis and IBD, scientists report identifying a gene and family of proteins critical... more
Scientists propose new material for regenerative medicine capable of controlling immune response  NEWS MEDICAL · 2 weeks
Scientists of Tomsk Polytechnic University jointly with the University of Montana proposed a new promising material for regenerative medicine for recovery of damaged tissues... more
Study finds molecular key to formation of mature and fully functioning T cells  NEWS MEDICAL · 3 weeks
In a finding that could help lead to new therapies for immune diseases like multiple sclerosis and IBD, scientists report in the... more
Scientists report evidence of immune response targeting brain cells in autism  NEWS MEDICAL · 4 weeks
Autism spectrum disorders affect one in 59 American children by age eight. With no known quantitative biological features, autism diagnoses are currently based on expert assessments... more
St George Street Capital signs agreement with AstraZeneca to develop two compounds in the clinic  NEWS MEDICAL · 4 weeks
St George Street Capital, a UK registered charity, has signed a license agreement with AstraZeneca to develop two... more
Frontotemporal dementia is associated with alterations in immune system function  SCIENCE DAILY · 4 weeks
Recent research has revealed increased inflammatory activity in a subgroup of patients with frontotemporal dementia (FTD). Increased inflammation was associated with parkinsonism symptoms and more rapid disease progression.... more
Researchers analyze levels of spicy compounds in chili peppers during ripening  NEWS MEDICAL · 5 days
Anyone who has tasted a hot chili pepper has felt the burn of capsaicinoids, the compounds that give peppers their spiciness, as well as possible health... more
CRISPR-Cas9 protein can help increase targeting accuracy in genome editing process  NEWS MEDICAL · 6 days
A team of researchers from City University of Hong Kong and Karolinska Institutet has recently developed a new protein that can help increase the targeting accuracy... more
Malaria pathogen under the X-ray microscope  SCIENCE DAILY · 2 weeks
Malaria is one of the most threatening infectious diseases in the world. An international team has now been able to investigate malaria pathogens in red blood cells in vivo using the BESSY II X-ray microscope and... more
Researchers investigate whether aspirin can decrease rate of intracranial aneurysm growth  NEWS MEDICAL · 2 weeks
Researchers conducted a database search to investigate whether aspirin can aid in the prevention of intracranial aneurysm rupture by hindering aneurysm growth. The researchers identified 146... more
Malaria pathogen under the X-ray microscope  PHYS.ORG · 2 weeks
Malaria is one of the most threatening infectious diseases in the world. An international team has now been able to investigate malaria pathogens in red blood cells in vivo using the BESSY II X-ray microscope and... more
Nanoparticle-induced neutrophil apoptosis increases survival in sepsis and alleviates neurological damage in stroke  Science Magazine · 6 days
Human neutrophils are the most abundant circulating leukocytes and contribute to acute and chronic inflammatory disorders. Neutrophil apoptosis is programed cell death... more
Immune 'control switch' could prevent brain injury in premature babies  SCIENCE DAILY · 2 weeks
About 15 million babies are born prematurely around the world each year and many suffer brain injuries when their immune response goes into overdrive. Researchers have now discovered... more
Immune reaction causes malaria organ damage  SCIENCE DAILY · 3 weeks
Immune cells can be the body's defenders and foes at the same time. more
Nitrogen-embedded polycyclic compound with strong antiaromaticity and stability  PHYS.ORG · 4 weeks
Nitrogen-embedded polycyclic compounds with strong antiaromaticity and stability were synthesized and isolated for the first time using pyrrole as a key unit. An expedited approach toward stable antiaromatic polycyclic compounds enables not... more
Measles resets children’s immune systems to a “baby-like” state  NEWS MEDICAL · 2 weeks
New studies have shown that measles can compromise the immune system’s ability to fight off other future infections. more
Eelgrass acid and resveratrol produced by cell factories for the first time  PHYS.ORG · 1 week
Leveraging nature's ways of adding sulfate groups by enzymes, scientists at The Novo Nordisk Foundation Center for Biosustainability at Technical University of Denmark (DTU)... more
Fullerene compounds can effectively kill non-small-cell lung carcinoma cells  NEWS MEDICAL · 3 weeks
The team of scientists from Skoltech Center for Energy Science and Technology, the Institute for Problems of Chemical Physics of Russian Academy of Sciences and National Taiwan University have discovered... more
Ants fight plant diseases  PHYS.ORG · 4 weeks
New research from Aarhus University shows that ants inhibit at least 14 plant diseases. Ants secrete antibiotics from glands in the body. On their legs and body, they also host colonies of bacteria that secrete antibiotics. It is probably these... more
How measles wipes out the body's immune memory  SCIENCE DAILY · 2 weeks
Study shows measles wipes out 20 to 50% of antibodies against an array of viruses and bacteria, depleting a child's previous immunity. Measles-ravaged immune system must 'relearn' how to protect the body... more
Ants inhibit at least 14 different plant diseases  SCIENCE DAILY · 4 weeks
New research shows that ants inhibit at least 14 different plant diseases. The small insects secrete antibiotics from glands in the body. On their legs and body, they also host colonies of... more
Newly discovered immune control switch could protect the brains of premature babies  NEWS MEDICAL · 2 weeks
Researchers have discovered an immune control switch that could protect the brains of premature babies, who often suffer brain injuries when their immune response... more
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