In mouse models of Alzheimer's disease, the investigational drug candidates known as CMS121 and J147 improve memory and slow the degeneration of brain cells. Now, researchers have shown how these compounds can also slow aging in healthy older mice, blocking the damage to brain cells that normally occurs during aging and restoring the levels of specific molecules to those seen in younger brains.... SCIENCE DAILY · 6 months
Epidemiologists develop new tool for measuring the pace of aging across the life course  SCIENCE DAILY · 4 weeks
A study is reporting a blood-DNA-methylation measure that is sensitive to variation in the pace of biological aging among individuals... more
Aging neurons accumulate DNA damage  SCIENCE DAILY · 2 weeks
Neuroscientists have discovered that an enzyme called HDAC1 is critical for repairing age-related DNA damage to genes involved in memory and other cognitive functions. HDAC1 is often diminished in both Alzheimer's patients and in normally aging adults, and... more
Cancer drug nilotinib found to be safe and well-tolerated in Alzheimer's disease clinical trial  NEWS MEDICAL · 5 days
A Georgetown University Medical Center clinical trial investigating the cancer drug nilotinib in people with Alzheimer's disease finds that it... more
Two marine molecules show potential to treat Alzheimer's disease  NEWS MEDICAL · 7 days
An interdisciplinary research study of the University of Barcelona identified two potential candidates to treat Alzheimer's disease. These are two marine molecules, meridianine and lignarenone B, able to alter the... more
Study examines the link between flavenoid-rich foods and risk of Alzheimer’s disease  NEWS MEDICAL · 4 weeks
Older adults who consumed small amounts of flavonoid-rich foods, such as berries, apples and tea, were two to four times more likely to develop... more
Study finds that aging neurons accumulate DNA damage  MIT · 2 weeks
Reactivating an enzyme that promotes DNA repair can help to reverse age-related cognitive decline in mice. more
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“They are strong drug candidates for the treatment of human coronavirus infections because they have already been successful in animals (cats),” writes the team. “The work here lays the framework... more
[Editors' Choice] A grim scorekeeper of biological aging  Science Magazine · 1 week
An epigenetic clock set to predict lifespan shows accelerated biological aging processes in male veterans with posttraumatic stress disorder. more
Antiepileptic drug use linked to higher risk of death among people with Alzheimer’s disease  NEWS MEDICAL · 4 hours
The use of antiepileptic drugs is associated with a higher risk of death among persons with Alzheimer’s disease, according to... more
AI VIVO seeks pharma, biotech collaboration partners to advance drug candidates for COVID-19  NEWS MEDICAL · 3 weeks
AI VIVO, the Cambridge based company combining systems pharmacology and artificial intelligence (AI) to accelerate drug discovery, has announced that it is... more
New drug can prevent life-threatening anaphylaxis, shows study  NEWS MEDICAL · 17 hours
For someone with a food or drug allergy, the risk of life-threatening anaphylactic shock lurks around every corner. A new Northwestern Medicine study shows there might be a pill that can be... more
How toxic protein spreads in Alzheimer's disease  SCIENCE DAILY · 5 days
Toxic versions of the protein tau are believed to cause death of neurons of the brain in Alzheimer's disease. A new study shows that the spread of toxic tau in the human brain in... more
Researchers develop smart gold nanocages to break chemoresistance  PHYS.ORG · 20 hours
Chemotherapeutic drugs are the cornerstone of the treatment for numerous malignancies. However, current chemotherapy is still far from being satisfactory due to severe side effects of the chemotherapeutic agents and drug resistance... more
Study discovers inhibition of SARS-CoV-2 entry priming protein by approved drug  NEWS MEDICAL · 4 weeks
The COVID-19 pandemic caused by the severe acute respiratory syndrome -coronavirus 2 (SARS-CoV-2) has spread to most of the world, causing millions of cases and hundreds... more
Scientists find a new way to reverse symptoms of Fragile X  MIT · 2 weeks
Drug compound, tested in mice, could be effective in treating the leading heritable cause of intellectual disability and autism. more
Malaria drug shows no benefit in another coronavirus study  ABC NEWS · 4 weeks
A new study finds no evidence of benefit from a malaria drug widely promoted as a treatment for coronavirus infection more
Study provides further insights into the relationship between smoking and COVID-19  NEWS MEDICAL · 3 weeks
A Canadian study available on the preprint server medRxiv* shows that current smokers are slightly more likely than never smokers to test positive for coronavirus disease... more
Drug Teixobactin shows promise against drug-resistant superbugs  NEWS MEDICAL · 4 hours
Two well-known superbugs are the gram-positive methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE). A new drug Teixobactin has shown promise against these microbes. The study titled, “The Killing Mechanism of Teixobactin against Methicillin-Resistant... more
Study shows how toxic protein leads to neuronal death and dementia  NEWS MEDICAL · 6 days
Toxic versions of the protein tau are believed to cause the death of neurons of the brain in Alzheimer's disease. more
Study evaluates the effectiveness of interferon beta 1b in COVID-19 pneumonia  NEWS MEDICAL · 2 weeks
As the world struggles to overcome the current COVID-19 pandemic with non-pharmacological interventions, in the absence of an effective drug or vaccine, existing immunomodulators are being... more
More berries, apples and tea may have protective benefits against Alzheimer's  SCIENCE DAILY · 4 weeks
Older adults with low intake of foods and drinks containing flavonoids, such as berries, apples, and tea, were more likely to develop Alzheimer's disease and related... more
UN says 7 or 8 `top' candidates for a COVID-19 vaccine exist  ABC NEWS · 3 weeks
The World Health Organization chief says there are around seven or eight “top” candidates for a vaccine to combat the novel coronavirus, and work... more
Antiviral drug can speed up recovery of COVID-19 patients, study shows  SCIENCE DAILY · 3 weeks
Research shows for the first time that interferon-alpha2b improves virus clearance and decreases levels of inflammatory markers in COVID-19 patients. more
Study shows hydroxychloroquine's harmful effects on heart rhythm  SCIENCE DAILY · 2 days
The malaria drug hydroxychloroquine, which has been promoted as a potential treatment for Covid-19, is known to have potentially serious effects on heart rhythms. Now, a team of researchers has used an... more
Research provides new evidence for potential blood-based biomarker for Alzheimer's  NEWS MEDICAL · 1 week
A potential blood-based biomarker for Alzheimer's and other neurodegenerative diseases seems even more promising thanks to new research from a Massachusetts General Hospital-led study. more
AGS releases high-priority questions for election candidates  NEWS MEDICAL · 3 weeks
With primary and general elections on the horizon across the U.S., the American Geriatrics Society (AGS) today released a series of high-priority questions for candidates. more
Drug combination could eliminate side effects of once-popular diabetes treatment  SCIENCE DAILY · 2 weeks
A new study shows how an effective but largely abandoned treatment for Type 2 diabetes could be used again in combination with another drug to eliminate problematic side... more
Day services may help improve cognitive function of Alzheimer's patients  NEWS MEDICAL · 4 weeks
Day services—programs designed to provide stimulation in a safe environment during the day for adults with physical and mental impairments—may help improve the cognitive function of adults with... more
2 accused of false Alzheimer's diagnoses charged with fraud  ABC NEWS · 2 weeks
A former director of an Ohio memory-loss clinic accused by dozens of patients of falsely diagnosing them with Alzheimer’s disease has been indicted on federal fraud charges more
Antiviral drug can help accelerate recovery of COVID-19 patients, study shows  NEWS MEDICAL · 3 weeks
An international team of researchers led by Dr. Eleanor Fish, emerita scientist at the Toronto General Hospital Research Institute, University Health Network, and professor in the... more
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