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Researchers discover drug that could combat brain cell death in those with Alzheimer's disease
PHYS.ORG One of the hallmark traits of Alzheimer's disease, a debilitating disorder marked by memory deficits and general cognitive decline, is... 11 minutes
Taking a close look at bacteria
PHYS.ORG Yong Wang, assistant professor of physics, and graduate student Asmaa Sadoon have been studying how molecules travel through bacterial cytoplasm in order to understand more about how these tiny organisms function. Using new high-tech tools, they... 11 minutes
Studying the hotbed of horizontal gene transfers
PHYS.ORG For over 200,000 years, humans and their gut microbiomes have coevolved into some of the most complex collections of living organisms on the planet. But as human lifestyles vary from the urban to rural,... 11 minutes
The role of the Atg2 protein in tethering pre-autophagosomal membranes to the endoplasmic reticulum
PHYS.ORG Postdoctoral Researcher Tetsuya Kotani, Associate Professor Hitoshi Nakatogawa, Honorary Professor Yoshinori Ohsumi and colleagues at Tokyo Institute of Technology have... 28 minutes
Researchers have discovered a new cell structure
PHYS.ORG A new structure in human cells has been discovered by researchers at Karolinska Institutet in Sweden in collaboration with colleagues in the U.K. The structure is a new type of protein complex that the... 28 minutes
New diagnostic platform simultaneously screens for all known pathogenic bacteria
NEWS MEDICAL Scientists at the Center for Infection and Immunity in the Columbia University Mailman School of Public Health have developed the first diagnostic platform that can simultaneously screen for... 34 minutes
New type of molecule shows early promise against treatment-resistant prostate cancer
NEWS MEDICAL A new type of molecule blocks the action of genes that drive the growth of therapy-resistant prostate cancer, a new study finds. 1 hour
Breakthrough test screens for all known bacterial infections
PHYS.ORG Scientists at the Center for Infection and Immunity (CII) in the Columbia University Mailman School of Public Health have developed the first diagnostic platform that can simultaneously screen for all known human... 2 hours
Study: Atg2 tethers pre-autophagosomal membrane to endoplasmic reticulum during autophagosome formation
NEWS MEDICAL Postdoctoral Researcher Tetsuya Kotani, Associate Professor Hitoshi Nakatogawa, Honorary Professor Yoshinori Ohsumi and colleagues at Tokyo Institute of Technology have analyzed the Atg protein Atg2, whose... 4 hours
Knowledge of sex differences in lower urinary tract may help stimulate breakthroughs in diagnosis, management
NEWS MEDICAL The biological differences between women and men go beyond basic anatomy. Researchers must consider sex differences down to... 5 hours
Forbius initiates Phase 2a trial evaluating efficacy, safety of AVID100 in patients with squamous NSCLC
NEWS MEDICAL Forbius, a clinical stage company developing biotherapeutics targeting EGFR and TGF-β pathways, today announced that the first patient... 5 hours
Map of human liver cells reveals molecular make-up of individual cells
NEWS MEDICAL A map of the cells in the human liver has been created by University Health Network Transplant Program and University of Toronto researchers, revealing for the... 6 hours
New discovery may lead to better treatment options for pancreatic cancer patients
NEWS MEDICAL Pancreatic cancer is one of the most difficult cancers to treat and is a leading cause of cancer-related deaths. Now, Sidney Kimmel Cancer Center... 6 hours
Salk researchers advance sonogenetics technology for treating neurological conditions
NEWS MEDICAL The emerging technology of sonogenetics--a technique where cells are controlled by sound--offers the potential to one day replace pharmaceutical drugs or invasive surgical treatments for neurological conditions like epilepsy, Parkinson's... 7 hours
New approach may lead to better diagnostic techniques for autoimmune disorders
NEWS MEDICAL If we really want to know how our body's cells work - or don't work, in the case of disease - we might need to look... 7 hours
NCI grant awarded to Abramson Cancer Center to study CAR T cells In solid tumors
NEWS MEDICAL A new program project grant from the National Cancer Institute will fund research by the Translational Center of... 7 hours
Research offers new hope to men who received childhood cancer treatment
NEWS MEDICAL Researchers have discovered a way to grow human stem cells destined to become mature sperm in an effort to provide fertility options later in life to... 9 hours
This Man Got a Seemingly Harmless Bug Bite. It Turned Into a Flesh-Eating Infection.
LIVE SCIENCE What started as a simple bug bite on a young man's knee soon turned life-threatening when the itchy bump developed... 13 hours
WATCH: What is multiple sclerosis?
ABC NEWS Multiple sclerosis, or MS, is a chronic disorder where cells from the immune system attack the nerve cells of the central nervous system (CNS). 15 hours
Researchers wake-up DNA from soil bacteria to discover novel acid antibiotic
SCIENCE DAILY Scleric Acid has been discovered by capturing and engineering a DNA fragment from soil bacteria Streptomyces sclerotialus, and could help fight bacterial infections. 16 hours
More than just anatomy: Sex differences in lower urinary tract
SCIENCE DAILY The biological differences between women and men go beyond basic anatomy. Researchers must consider sex differences down to the cellular level in order to discover crucial information about... 16 hours
Heredity matters: Ancestral protease functions as protein import motor in chloroplasts
SCIENCE DAILY Researchers identified a large novel protein complex in the inner chloroplast membrane that functions as a motor to import proteins into the chloroplast. Components of the... 16 hours
Ancient enzymes the catalysts for new discoveries
SCIENCE DAILY New research recreating 450 million-year-old enzymes has resulted in a biochemical engineering 'hack' which could lead to new drugs, flavors, fragrances and biofuels. 16 hours
Genetic profile for a section of Aspergillus fungi
SCIENCE DAILY Aspergillus is an important fungal genus, with roles in agriculture, biotechnology, human health, enzyme production and food fermentation. Scientists now present the first large analysis of an Aspergillus fungal subgroup, section Nigri. 17 hours
Cells that change jobs to fight diabetes
SCIENCE DAILY Diabetes is characterized by persistent high blood sugar levels that occur when certain cells in the pancreas -- the insulin-producing cells -- are destroyed or are no longer able to secrete insulin. Researchers have... 17 hours
Losing control of gene activity in Alzheimer's disease
SCIENCE DAILY Pioneering research into the mechanisms controlling gene activity in the brain could hold the key to understanding Alzheimer's disease and might help identify effective treatments in the future. 17 hours
Structure of spherical viruses aren't as perfect as we thought
PHYS.ORG Determining the structure of a virus is an important step in understanding and treating viral disease. For decades, structural biologists have been using cryo-electron microscopy to create increasingly... 17 hours
Man's Bug Bite Turns into Rare 'Flesh-Eating' Infection
LIVE SCIENCE What started as a simple bug bite on a young man's knee soon turned life-threatening when the itchy bump developed into an infection with "flesh-eating" bacteria. 17 hours
New human cell structure discovered
SCIENCE DAILY A new structure in human cells has been discovered. The structure is a new type of protein complex that the cell uses to attach to its surroundings and proves to play a key part in cell division. 18 hours
Mars likely to have enough oxygen to support life: study
PHYS.ORG Salty water just below the surface of Mars could hold enough oxygen to support the kind of microbial life that emerged and flourished on Earth billions of years... 18 hours
Study: Targeting specific genomic mutation in breast cancer improves survival
NEWS MEDICAL Targeting a common mutation in patients with hormone receptor positive (HR+) HER2 negative (HER2-) advanced breast cancer with the alpha-specific phosphatidylinositol-3-kinase (PI3K) inhibitor alpelisib significantly improves progression-free survival,... 18 hours
Researchers discover new structure in human cells
NEWS MEDICAL A new structure in human cells has been discovered by researchers at Karolinska Institutet in Sweden in collaboration with colleagues in the UK. 18 hours
Salty Martian Water Could Have Enough Oxygen to Support Life
SPACE.COM Some pockets of salty water buried just beneath the Martian surface could have enough oxygen to support microbes, and perhaps even simple animal life such as sponges, a... 19 hours
Studying the hotbed of horizontal gene transfers
MIT Global Microbiome Conservancy research reveals surprising new insights into human gut microbiomes. 19 hours
Scientists make new 'green' electronic polymer-based films with protein nanowires
PHYS.ORG An interdisciplinary team of scientists at the University of Massachusetts Amherst has produced a new class of electronic materials that may lead to a "green," more sustainable future... 19 hours
Ancient enzymes the catalysts for new discoveries
PHYS.ORG University of Queensland-led research recreating 450 million-year-old enzymes has resulted in a biochemical engineering 'hack' which could lead to new drugs, flavours, fragrances and biofuels. 20 hours
Cellular trash cans reveal the roles of proteins in disease
PHYS.ORG If we really want to know how our body's cells work—or don't work, in the case of disease—we might need to look beyond their genes and even beyond... 20 hours
New protein sequencing method could transform biological research
PHYS.ORG A team of researchers at The University of Texas at Austin has demonstrated a new way to sequence proteins that is much more sensitive than existing technology, identifying individual protein molecules rather... 21 hours
Researchers wake-up DNA from soil bacteria to discover novel acid antibiotic
PHYS.ORG Scleric Acid has been discovered by capturing and engineering a DNA fragment from soil bacteria Streptomyces sclerotialus, and could help fight bacterial infections—by researchers at the... 21 hours
Cells that change jobs to fight diabetes
PHYS.ORG Diabetes is characterized by persistent high blood sugar levels that occur when certain cells in the pancreas—the insulin-producing β cells—are destroyed or are no longer able to secrete insulin. Researchers at the University of... 21 hours
How this researcher's risky idea could mean big things for regenerative medicine
PHYS.ORG Every cell in your body contains thousands of different proteins. These complicated molecules regulate chemical reactions, bind to invading bacteria or viruses, carry signals... 21 hours
Does your dog have a bacterial infection? This test could tell you in two minutes.
PHYS.ORG Want to know which bacteria are making your dog or cat sick? Northeastern professor Edgar Goluch has started... 23 hours
Researchers discover how acne-causing bacteria resist treatment
NEWS MEDICAL Researchers in Sweden have discovered how acne-causing bacteria feed off their human hosts. The study, which was performed at KTH Royal Institute of Technology, could make it possible to find effective ways to treat... 23 hours
Understanding architecture of cancer-linked BAF protein complexes provides insight into disease
PHYS.ORG In 2013, Broad Institute member Cigall Kadoch, then a postdoctoral researcher at Stanford University, discovered that approximately 20 percent of all human cancers involve mutations in... 23 hours
Study describes cellular factories in greater detail
PHYS.ORG Many important natural products such as antibiotics, immunosuppressants and cancer drugs are derived from microorganisms. These natural products are often small proteins or peptides generated in the cell by NRPS enzymes similar to a... 23 hours
On This Day in Space! Oct. 22, 1992: Gene Roddenberry's Ashes Launch into Space
SPACE.COM On Oct. 22, 1992, the space shuttle Columbia launched into space with the ashes of Gene Roddenberry, the creator of... 1 day
IDT to demonstrate CRISPR expertise at European-focused events
NEWS MEDICAL As an advocate for the genomics age, Integrated DNA Technologies (IDT), will showcase its renowned CRISPR expertise at a series of European-focused events. 1 day
Medical News Today: Antibiotic plus probiotic combination may kill off superbugs
MNT A combination of antibiotics and probiotics has successfully wiped out MRSA and Pseudomonas aeruginosa — two drug resistant bacteria. 1 day
FOTIVDA expected to be included in new ESMO guidelines for advanced renal cell carcinoma
NEWS MEDICAL EUSA Pharma welcomes the news that FOTIVDA (tivozanib) is expected to be included in the upcoming European Society of Medical... 1 day
Genentech’s combination therapy improves outcome in patients with non-squamous non-small cell lung cancer
NEWS MEDICAL Genentech, a member of the Roche Group, today announced positive results from the Phase III IMpower130 study of Tecentriq (atezolizumab) plus chemotherapy... 1 day
Zika outbreak in northern India state exceeds 100 cases
ABC NEWS The number of Zika virus cases has crossed 100 in Rajasthan, a state in northern India where palaces and forts draw large numbers of tourists each year 1 day
Merck presents MK-1454 Phase 1 data for treatment of advanced solid tumors or lymphomas
NEWS MEDICAL Merck, known as MSD outside the United States and Canada, today announced the first presentation of preliminary data from a... 1 day
Maintenance therapy with olaparib improves progression-free survival in advanced ovarian cancer patients
NEWS MEDICAL Two-year maintenance therapy with olaparib, a PARP (poly ADP ribose polymerase) inhibitor, olaparib, led to a substantial, unprecedented improvement in progression-free survival (PFS) in... 1 day
Educational initiatives needed to improve knowledge about biosimilars in oncology
NEWS MEDICAL Biological medicines are responsible for some of the most promising innovations in cancer treatment, including immunotherapy, targeted drugs and vaccines - but they are also expensive. 1 day
Japanese Nobel chemistry laureate Shimomura dies at 90
PHYS.ORG Japanese-born Marine biologist Osamu Shimomura, who won the Nobel Prize in chemistry, has died. He was 90. 1 day
Study shows potential of avelumab plus axitinib as new treatment option for patients with advanced RCC
NEWS MEDICAL A combination of the immune checkpoint blocker, avelumab, plus the tyrosine kinase inhibitor, axitinib, significantly improves... 1 day
Takeda presents Vedolizumab phase 3 VISIBLE 1 trial results for treatment of moderately to severely active ulcerative colitis
NEWS MEDICAL Takeda Pharmaceutical Company Limited today announced results from the phase 3 VISIBLE... 1 day
Engineered Enzyme Could Treat Nicotine Addiction
SCI-NEWS.COM A team of scientists at the Scripps Research Institute has synthesized a new nicotine-degrading enzyme and successfully tested it in nicotine-dependent rats. Named NicA2-J1,... 1 day
Study: Erlotinib improves progression-free survival in EGFR mutated NSCLC
NEWS MEDICAL Neoadjuvant erlotinib benefits selected epidermal growth factor receptor (EGFR)-mutated patients who undergo complete resection of stage IIIA-N2 stage non-small cell lung cancer(NSCLC), shows a randomized study comparing erlotinib with gemcitabine... 1 day
Immune therapy may be potential treatment option for patients with hard-to-treat ankylosing spondylitis
NEWS MEDICAL Results from a phase 3 clinical trial indicate that patients who have not benefited from standard therapy for ankylosing spondylitis, a chronic... 1 day
Exelixis presents CABOSUN and METEOR trial results in patients with advanced renal cell carcinoma
NEWS MEDICAL Exelixis, Inc. today announced results from two analyses evaluating the effect of PD-L1 expression or prior treatment with immune checkpoint... 1 day
Takeda announces positive Phase 3 ALTA-1L data in first-line therapy for advanced ALK+ NSCLC
NEWS MEDICAL Takeda Pharmaceutical Company Limited today announced that intracranial efficacy data from the Phase 3 ALTA-1L (ALK in Lung Cancer Trial... 1 day
Gilead Sciences presents Phase 3 results of filgotinib in biologic-experienced rheumatoid arthritis at 2018 ACR/ARHP Annual Meeting
NEWS MEDICAL Gilead Sciences, Inc. and Galapagos NV today announced detailed results from the Phase 3... 1 day
X4 Pharmaceuticals announces clinical data of X4P-001-IO and Opdivo in patients with clear cell renal cell carcinoma
NEWS MEDICAL X4 Pharmaceuticals, a clinical stage biotechnology company developing novel CXCR4 antagonists to improve immune... 1 day
Deadly attack amid Ebola outbreak stalls containment efforts
ABC NEWS Deadly rebel attack at center of Ebola outbreak stalls virus-containment efforts 2 days
Deadly rebel attack in center of Ebola outbreak stalls work
ABC NEWS Deadly rebel attack in center of Ebola outbreak forces virus containment efforts to stop again 2 days
AstraZeneca's Lynparza shown to put brakes on ovarian cancer
REUTERS An AstraZeneca drug that blocks a cancer cell's ability to repair its genetic code greatly reduced the risk... 2 days
Medical News Today: Cancer: Even healthy tissue is 'riddled with mutations'
MNT A new study charts the slow build-up of genetic mutations. The researchers are surprised to find that even healthy human tissue carries many mutants. 2 days
Roche takes on Loxo, Bayer in gene-defined cancer class
REUTERS Roche's entrectinib cancer pill was shown to shrink tumors in 57 percent of patients within a group that... 2 days
Giant study links DNA variants to same-sex behavior
Science Magazine People who reported having at least one same-sex partner more likely to share certain genetic markers 2 days
ApoE4 gene linked with chronic inflammation increases risk for Alzheimer's disease
NEWS MEDICAL While it is widely shown that possessing the ApoE4 gene is the major genetic risk factor of Alzheimer's disease, not all ApoE4 carriers develop AD. 2 days
Does herpes cause Alzheimer's?
SCIENCE DAILY Herpes is the dreaded 'gift that keeps on giving'. But could it also be taking our memories? Decades of research show a striking correlation between Alzheimer's disease risk and infection with Herpes Simplex Virus 1 (HSV1) in people carrying a... 2 days
With a microbe-produced toxin, bacteria prove old dogs can learn new tricks
SCIENCE DAILY In the ongoing chemical battles among bacteria and their microbial neighbors, a new toxin has been uncovered. This unfamiliar toxin behaves in a familiar... 2 days
A single missing gene leads to miscarriage
SCIENCE DAILY A single gene of the mother plays such a crucial role in the development of the placenta that its dysfunction leads to miscarriages. Researchers have observed this in so-called knockout mice that were specifically... 2 days
En route to custom-designed natural products
SCIENCE DAILY Microorganisms often assemble natural products similar to industrial assembly lines. Certain enzymes, non-ribosomal peptide synthetases (NRPS) play a key role in this process. Biotechnologists have now been able to discover how these enzymes interact with each... 2 days
Why some cancers affect only young women
SCIENCE DAILY Among several forms of pancreatic cancer, one of them affects specifically women, often young, even though the pancreas is an organ with little exposure to sex hormones. This pancreatic cancer, known as 'mucinous cyst,'... 2 days
Novartis drug cut death risk by 35 percent in gene mutation breast cancer
REUTERS An experimental cancer drug that Novartis hopes will raise the... 3 days
DNA differences are linked to having same-sex sexual partners
SCIENCE-NEWS Genetic differences are associated with choosing same-sex partners in both men and women. 3 days
Medical News Today: Using light to destroy metastatic breast cancer
MNT Metastatic breast cancer may soon be treated using light to activate photo-sensitive drugs which, in turn, can target cancer cells and avoid healthy ones. 3 days
Bug guts shed light on Central America Chagas disease
SCIENCE DAILY In Central America, Chagas disease, or American trypanosomiasis, is spread by the 'kissing bug' Triatoma dimidiata. By collecting DNA from the guts of these bugs, researchers reporting in PLOS Neglected... 3 days
A tailormade drug developed in record time may save girl from fatal brain disease
Science Magazine DNA-based therapy for Batten disease shows promise of personalized medicine 3 days
MS genes formerly missing-in-action have been found
SCIENCE DAILY Scientists have cracked a tough nut in multiple sclerosis: where are all the genes? 3 days
Making gene therapy delivery safer and more efficient
SCIENCE DAILY Viral vectors used to deliver gene therapies undergo spontaneous changes during manufacturing which affects their structure and function. As gene therapy approaches become more common for treating disease, managing consistency of the... 3 days
Brain cells called astrocytes have unexpected role in brain 'plasticity'
SCIENCE DAILY Researchers have shown that astrocytes -- long-overlooked supportive cells in the brain -- help to enable the brain's plasticity, a new role for astrocytes that was not previously... 3 days
Genomic analysis offers insight into 2018 Nigeria Lassa fever outbreak
SCIENCE DAILY A surge in Lassa fever cases in Nigeria in 2018 doesn't appear to be linked to a single virus strain or increased human-to-human transmission, according to genomic analysis. 4 days
Scientists grow functioning human neural networks in 3D from stem cells
SCIENCE DAILY A team of researchers has developed three-dimensional (3D) human tissue culture models for the central nervous system that mimic structural and functional features of the brain... 4 days
Functional regeneration of tendons using scaffolds with physical anisotropy engineered via microarchitectural manipulation
Science Magazine Structural and hierarchical anisotropy underlies the structure-function relationship of most living tissues. Attempts to exploit the interplay between cells and their immediate... 4 days
Insight into how nanoparticles interact with biological systems
SCIENCE DAILY Personal electronic devices are a growing source of the world's electronic waste. Many of these products use nanomaterials, but little is known about how nanoparticles interact with the environment. Now chemists have... 4 days
Cell surface polysaccharides of Bifidobacterium bifidum induce the generation of Foxp3+ regulatory T cells
Science Magazine Dysregulation of intestinal microflora is linked to inflammatory disorders associated with compromised immunosuppressive functions of Foxp3+ T regulatory (Treg) cells.... 4 days
Glycans for good
Science Magazine The gut commensal bacterium Bifidobacterium bifidum promotes immune tolerance by facilitating the induction of colonic regulatory T cells. 4 days
Medical News Today: Antibiotic resistance: Breakthrough study offers solution
MNT Mice treated with small molecules that stop bacteria forming toxins survived MRSA infection without the need for antibiotics, study found. 4 days
Everything you need to know about Ebola
ABC NEWS The Democratic Republic of the Congo is fighting its 10th outbreak of the Ebola virus. Here is a look at the causes, the symptoms and the history of the deadly disease. 4 days
New cell movement process key to understanding and repairing facial malformations
SCIENCE DAILY The embryonic stem cells that form facial features, called neural crest cells, use an unexpected mechanism of moving from the back of the head to the... 4 days
Advanced sequencing technology provides new insights into human mitochondrial diseases
SCIENCE DAILY Researchers have for the first time been able to investigate the abundance and methyl modifications of all mitochondrial tRNAs in patients suffering from one of the most common... 4 days
New therapies pack a triple-drug punch to treat cystic fibrosis
SCIENCE-NEWS In testing, a triple-drug therapy significantly improved lung function in cystic fibrosis patients with the most common disease-causing mutation. 4 days
Medical News Today: Herpes may account for 50 percent of Alzheimer's cases
MNT A large review suggests that the herpes virus may result in a heightened risk of senile dementia, and may account for numerous Alzheimer's diagnoses. 4 days
Herpes may account for 50 percent of Alzheimer's cases
MNT A large review suggests that the herpes virus may result in a heightened risk of senile dementia, and may account for numerous Alzheimer's diagnoses. 4 days
By Middle Age, Healthy People Have Way More Cancer-Causing Mutations Than We Thought
LIVE SCIENCE Our cells change over time. Apparently, a lot. 4 days
Could we prevent Alzheimer's disease by treating herpes?
NEWS MEDICAL An exciting new paper suggests that over half of all cases of Alzheimer’s disease could be traced back to herpes simplex virus 1, which causes cold sores. 4 days
Scientists report technique to prolong lifespan of perovskite solar cells
PHYS.ORG A group of chemists at Kaunas University of Technology (KTU), Lithuania, together with the physicists from Vilnius University and the Swiss Federal Institute of Technology, Lausanne (EPFL), have... 4 days
From peaceful coexistence to potential peril: The bacteria that live in and on us
PHYS.ORG
Cases of Acute Flaccid Myelitis on the rise across U.S.
NEWS MEDICAL
New test rapidly identifies antibiotic-resistant superbugs
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Artificial intelligence aids automatic monitoring of single molecules in cells
PHYS.ORG