Microbiology
Fasting reduces inflammation and improves chronic inflammatory diseases, study finds  NEWS MEDICAL · 31 minutes
Fasting regimens have gained public and scientific interest in recent years, but fasting shouldn't be dismissed as a fad. In a study published in Cell, Mount Sinai researchers... more
New model developed to optimize and personalize radiotherapy for cancer patients  NEWS MEDICAL · 1 hour
A personalized approach to cancer treatment has become more common over the last several decades, with numerous targeted drugs approved to treat particular tumor types with... more
Ludwig study uncovers novel vulnerability in MYC-driven cancers  NEWS MEDICAL · 1 hour
A Ludwig Cancer Research study has uncovered a novel vulnerability in tumors that are driven by a common cancer gene known as MYC. Such cancers, it found, are highly dependent on the... more
Virginia Tech professor wins NSF grant to study biofilm formation in bacteria  NEWS MEDICAL · 1 hour
Should I stay or should I go? This is a common question people ask themselves in their journey through life, but bacteria are also... more
Phase-change heterostructure enables ultralow noise and drift for memory operation  Science Magazine · 1 hour
Artificial intelligence and other data-intensive applications have escalated the demand for data storage and processing. New computing devices, e.g., phase-change random access memory (PCRAM) based neuro-inspired devices, are... more
N6-methyladenosine RNA modification-mediated cellular metabolism rewiring inhibits viral replication  Science Magazine · 1 hour
Host cell metabolism can be modulated by viral infection, affecting viral survival or clearance. The cellular metabolism rewiring mediated by N6-methyladenosine (m6A) modification in virus-host interaction remains largely unknown. Here... more
NAD+ cleavage activity by animal and plant TIR domains in cell death pathways  Science Magazine · 1 hour
SARM1 (sterile alpha and TIR motif containing 1) is responsible for depletion of nicotinamide adenine dinucleotide in its oxidized form (NAD+) during... more
Programmable CRISPR-responsive smart materials  Science Magazine · 1 hour
Stimuli-responsive materials activated by biological signals play an increasingly important role in biotechnology applications. We exploit the programmability of CRISPR-associated nucleases to actuate hydrogels containing DNA as a structural element or as an anchor for pendant groups. After activation by... more
The Malaria Cell Atlas: Single parasite transcriptomes across the complete Plasmodium life cycle  Science Magazine · 1 hour
Malaria parasites adopt a remarkable variety of morphological life stages as they transition through multiple mammalian host and mosquito vector environments. We... more
Persistence of neuronal representations through time and damage in the hippocampus  Science Magazine · 1 hour
How do neurons encode long-term memories? Bilateral imaging of neuronal activity in the mouse hippocampus reveals that, from one day to the next, ~40% of neurons... more
Phospho-dependent phase separation of FMRP and CAPRIN1 recapitulates regulation of translation and deadenylation  Science Magazine · 1 hour
Membraneless organelles involved in RNA processing are biomolecular condensates assembled by phase separation. Despite the important role of intrinsically disordered protein regions... more
Structure and conformational plasticity of the intact Thermus thermophilus V/A-type ATPase  Science Magazine · 1 hour
V (vacuolar)/A (archaeal)-type adenosine triphosphatases (ATPases), found in archaea and eubacteria, couple ATP hydrolysis or synthesis to proton translocation across the plasma membrane using the rotary-catalysis... more
TIR domains of plant immune receptors are NAD+-cleaving enzymes that promote cell death  Science Magazine · 1 hour
Plant nucleotide-binding leucine-rich repeat (NLR) immune receptors activate cell death and confer disease resistance by unknown mechanisms. We demonstrate that plant Toll/interleukin-1... more
The global soil community and its influence on biogeochemistry  Science Magazine · 1 hour
Soil organisms represent the most biologically diverse community on land and govern the turnover of the largest organic matter pool in the terrestrial biosphere. The highly complex nature of these... more
New tool mines scientific texts for fusion protein facts  PHYS.ORG · 2 hours
A new computational tool called ProtFus screens scientific literature to validate predictions about the activity of fusion proteins—proteins encoded by the joining of two genes that previously encoded two separate... more
Biomaterials smarten up with CRISPR  PHYS.ORG · 2 hours
The CRISPR-Cas system has become the go-to tool for researchers who study genes in an ever-growing list of organisms, and is being used to develop new gene therapies that potentially can correct a defect at a single nucleotide... more
Map of malaria behavior set to revolutionize research  PHYS.ORG · 2 hours
The first detailed map of individual malaria parasite behaviour across each stage of its complicated life cycle has been created by scientists. Researchers at the Wellcome Sanger Institute and their collaborators used... more
Structure of protein nanoturbine revealed  PHYS.ORG · 2 hours
Cells rely on protein complexes known as ATP synthases or ATPases for their energy needs. Adenosine triphosphate (ATP) molecules power most of the processes sustaining life. Structural biologist Professor Leonid Sazanov and his research group from the Institute... more
Cell suicide could hold key for brain health and food security  PHYS.ORG · 2 hours
Research into the self-destruction of cells in humans and plants could lead to treatments for neurodegenerative brain diseases and the development of disease-resistant plants. more
Experiments illuminate key component of plants' immune systems  PHYS.ORG · 2 hours
Plants, like humans and animals, have over millions of years evolved complex immune systems that fend off invading pathogens. But unlike many animals, plants lack adaptive immunity conferred by antibodies. This means... more
Tracing the evolution of vision in fruit flies  PHYS.ORG · 2 hours
The function of the visual photopigment rhodopsin and its action in the retina to facilitate vision is well understood. However, there remain questions about other biological functions of this family of proteins... more
New method classifies brain cells based on electrical signals  MIT · 2 hours
Making electrophysiology more informative, team shows how to distinguish four classes of cells by spike waveform. more
Using CRISPR to program gels with new functions  MIT · 2 hours
Smart materials change properties in response to specific DNA sequences; could be used in a variety of devices. more
Adaptation to life inside cattle may be driving E. coli to develop harmful features  PHYS.ORG · 2 hours
A large-scale study of the genetic differences and similarities among E. coli bacteria from cattle and humans indicates that features... more
Scientists successfully innoculate, grow crops in salt-damaged soil  SCIENCE DAILY · 2 hours
Researchers may have found a way to reverse falling crop yields caused by increasingly salty farmlands throughout the world. Scientists have used bacteria found in the roots of salt-tolerant plants to successfully... more
Tracing the evolution of vision  SCIENCE DAILY · 2 hours
The function of the visual photopigment rhodopsin and its action in the retina to facilitate vision is well understood. However, there remain questions about other biological functions of this family of proteins (opsins) and this has ramifications for... more
Genetic diversity couldn't save Darwin's finches  SCIENCE DAILY · 2 hours
Researchers found that Charles Darwin's famous finches defy what has long been considered a key to evolutionary success: genetic diversity. The study of the finches of the Galapagos Islands could change the way conservation biologists think... more
Comparison of three similar frontline breast cancer drugs reveals important differences  SCIENCE DAILY · 4 hours
First head-to-head comparison of CDK4/6 inhibitors in cell line and animal models of breast cancer reveals important differences, including one drug that exhibits unique, potentially advantageous... more
An unreported Zika outbreak in 2017 detected through travel surveillance and genetics  SCIENCE DAILY · 4 hours
By sequencing virus genomes from infected travelers, analyzing travel patterns and mosquito modeling, researchers unearthed a spike in Zika cases from travelers returning from... more
High-precision technique stores cellular 'memory' in DNA  SCIENCE DAILY · 4 hours
Researchers have created a technology called DOMINO to store complex 'memories' in the DNA of living cells, including human cells. This memory storage capacity can form the foundation of complex circuits that trigger a... more
Scorpion toxin that targets 'wasabi receptor' may help solve mystery of chronic pain  SCIENCE DAILY · 4 hours
Researchers have discovered a scorpion toxin that targets the 'wasabi receptor,' a chemical-sensing protein found in nerve cells that's responsible for the... more
Certain metabolites linked to stem cell function in the intestine  SCIENCE DAILY · 4 hours
Researchers have found that high levels of ketone bodies, molecules produced by the breakdown of fat, help the intestine to maintain a functional stem cell pool, which are... more
Materials scientists build a synthetic system with compartments like real cells  SCIENCE DAILY · 4 hours
Polymer chemists and materials scientists have achieved some notable advances that mimic Nature, but one of the most common and practical features of cells has so... more
Early life on Earth limited by enzyme  SCIENCE DAILY · 4 hours
A single enzyme found in early single-cell life forms could explain why oxygen levels in the atmosphere remained low for two billion years during the Proterozoic eon, preventing life colonizing land. more
Study links certain metabolites to stem cell function in the intestine  MIT · 4 hours
Molecules called ketone bodies may improve stem cells’ ability to regenerate new intestinal tissue. more
Study started for bacteria-free space missions  ESA · 5 hours
Bacteria grow everywhere, including inside the International Space Station. That is why ESA has selected the Luxembourg Institute of Science and Technology (LIST) to... more
Researchers reveal plant defense toolkit and insights for fighting crop diseases  PHYS.ORG · 5 hours
At an unprecedented scale, researchers have now cataloged the array of surveillance tools that plants use to detect disease-causing microbes across an entire species. Representing a... more
Materials scientists build a synthetic system with compartments like real cells  PHYS.ORG · 5 hours
Polymer chemists and materials scientists have achieved some notable advances that mimic Nature, but one of the most common and practical features of cells has so... more
Atacama Desert microbes may hold clues to life on Mars  PHYS.ORG · 5 hours
Microbial life on Mars may potentially be transported across the planet on dust particles carried by wind, according to a study conducted in the Atacama Desert in North... more
High-precision technique stores cellular 'memory' in DNA  PHYS.ORG · 5 hours
Using a technique that can precisely edit DNA bases, MIT researchers have created a way to store complex "memories" in the DNA of living cells, including human cells. more
Early life on Earth limited by enzyme  PHYS.ORG · 5 hours
The enzyme-nitrogenase-can be traced back to the universal common ancestor of all cells more than four billion years ago. more
Computer model could help test new sickle cell drugs  SCIENCE DAILY · 5 hours
A new computer model that captures the dynamics of the red blood cell sickling process could help in evaluating drugs for treating sickle cell disease. more
E-cigs can trigger same lung changes seen in smokers, emphysema  SCIENCE DAILY · 5 hours
Scientists found that the lungs of vapers -- like the lungs of smokers -- have elevated levels of protease enzymes, a condition known to cause emphysema in smokers.... more
Slow electrons to combat cancer  SCIENCE DAILY · 5 hours
Slow electons can be used to destroy cancer cells - but how exactly this happens has not been well understood. Now scientists have been able to demonstrate that a previously little-observed effect actually plays a pivotal role: Due... more
Washing laundry may be an underappreciated source of microplastic pollution  PHYS.ORG · 5 hours
Concerns over plastic in the ocean are growing in recent years. About 2.41 million tons of plastic waste enter the oceans every year, including approximately 15,000 plastic bags... more
Bacterial sex drives evolution of microbes to conquer and colonize the gut  PHYS.ORG · 5 hours
Bacterial sex drives evolution of microbes to conquer and colonize the gut. This discovery constitutes a paradigm shift and opens the possibility to design... more
Slow electrons to combat cancer  PHYS.ORG · 5 hours
Ion beams are often used today in cancer treatment: this involves electrically charged atoms being fired at the tumour to destroy cancer cells. Although, it's not actually the ions themselves that cause the decisive damage. When ions penetrate... more
There are way more species of horseshoe bats than scientists thought  SCIENCE DAILY · 5 hours
Horseshoe bats are bizarre-looking animals with giant ears and elaborate flaps of skin on their noses that they use like satellite dishes. There are about a... more
Enzyme that helps protect us from stress linked to liver cancer growth  SCIENCE DAILY · 5 hours
An enzyme induced by stress to help reduce production of damaging free radicals is also used by liver cancer to regulate two major cell... more
The origins and evolution of life: Re-examining the evidence of early life traces  PHYS.ORG · 6 hours
Even though Earth has been habitable (has had surface liquid water and some crust) for 4.3 billion years, and the oldest putative... more
Exploring the interaction of polystyrene nanoplastics and blood plasma proteins  PHYS.ORG · 6 hours
Collaborative research at ANSTO led by Mr Shinji Kihara and A/Prof. Duncan McGillivray of The MacDiarmid Institute, New Zealand with ANSTO's Dr. Jitendra Mata, scientists from the University... more
Greenhouse uses predatory insects for pest control  PHYS.ORG · 7 hours
The William & Mary greenhouse has started a new program to limit the use of chemicals by relying on predatory insects for pest control. It's the biological equivalent of fighting fire with fire ⁠—... more
Research team reveals molecular program that controls cells' capacity for division  PHYS.ORG · 7 hours
Cells in the body proliferate at different rates. Some divide constantly and throughout life, like the ones that line the gut. Others divide only rarely, sometimes... more
Enzyme induced by stress associated with liver cancer growth  NEWS MEDICAL · 7 hours
An enzyme induced by stress to help reduce production of damaging free radicals is also used by liver cancer to regulate two major cell proliferation pathways that enable the cancer... more
Magnets are being used to extract algal molecules for the beauty, bioplastics industries  PHYS.ORG · 8 hours
Entrepreneurs in the aquaculture sector face a problem—extracting all the valuable molecules from seaweed and algal cells is still really difficult. But... more
RNA sequencing data added to robust study of Parkinson's disease  NEWS MEDICAL · 9 hours
A team at the Keck School of Medicine of USC, in collaboration with The Michael J. Fox Foundation for Parkinson's Research, has just added a crucial new element... more
New insights into protein transport could help define strategies for treating eye disease  NEWS MEDICAL · 11 hours
Many forms of vision loss stem from a common source: impaired communication between the eye and the brain. And at the root... more
'Kissing loops' in lncRNA essential for tumor suppressor function  NEWS MEDICAL · 12 hours
Human cells - like those of many other organisms - have developed mechanisms to protect us from cancer. more
UC San Diego researchers identify new therapeutic approach to kill cancer cells  NEWS MEDICAL · 12 hours
Epithelial cancers, such as cancers of the lung and pancreas, use the ανβ3 molecule to gain drug resistance to standard cancer therapies and to... more
There are way more species of horseshoe bats than scientists thought  PHYS.ORG · 12 hours
Horseshoe bats are bizarre-looking animals with giant ears and elaborate flaps of skin on their noses that they use like satellite dishes. There are about a... more
Researchers unlock mysteries surrounding maternal/fetal cellular communication during pregnancy  NEWS MEDICAL · 13 hours
Researchers have unlocked mysteries surrounding how a pregnant mother's cells and her fetus' cells communicate throughout pregnancy. more
International study identifies new drug target for treating glioblastoma  NEWS MEDICAL · 14 hours
A new international study co-led by Cleveland Clinic has identified a new drug target for treating glioblastoma. This target is part of a never-before defined cellular pathway found to contribute... more
Lungs feed deadly bacteria in cystic fibrosis  NEWS MEDICAL · 14 hours
In cystic fibrosis, Pseudomonas aeruginosa is a much-feared pathogen. The bacterium easily colonizes the lungs of people with cystic fibrosis, leading to chronic infections that are almost impossible to eradicate and are ultimately fatal. more
UCI study finds link between brain immune cells and Alzheimer's disease development  NEWS MEDICAL · 16 hours
Scientists from the University of California, Irvine School of Biological Sciences have discovered how to forestall Alzheimer's disease in a laboratory setting, a finding... more
Medical News Today: Can you get a yeast infection from antibiotics?  MNT · 19 hours
Taking certain antibiotics can lead to a yeast infection in the vagina. This is because the antibiotics kill bacteria that support vaginal health. Learn more here. more
Medical News Today: Could targeting variants of this gene help fight Alzheimer's disease?  MNT · 19 hours
Researchers have found variants of a gene that influence Alzheimer's disease risk through their effect on a cerebrospinal fluid protein. more
Could targeting variants of this gene help fight Alzheimer's disease?  MNT · 19 hours
Researchers have found variants of a gene that influence Alzheimer's disease risk through their effect on a cerebrospinal fluid protein. more
Parasite needs chemical (lipid/nutrient) in cat intestines for sex  SCIENCE DAILY · 21 hours
Toxoplasma gondii is a microbial parasite that infects humans and but needs cats to complete its full life cycle. New research shows why: the sexual phase of the parasite's life... more
Scientists propose network of imaging centers to drive innovation in biological research  SCIENCE DAILY · 21 hours
When sparks fly to innovate new technologies for imaging life at the microscopic scale, often diverse researchers are nudging each other with a kind... more
Scientists probe how distinct liquid organelles in cells are created  SCIENCE DAILY · 21 hours
One way biological compounds inside cells stay organized is through membrane-less organelles (MLOs) -- wall-less liquid droplets made from proteins and RNA that clump together and stay separate... more
Protein-transport discovery may help define new strategies for treating eye disease  SCIENCE DAILY · 21 hours
Many forms of vision loss stem from a common source: impaired communication between the eye and the brain. And at the root of that communication are... more
Scientists propose network of imaging centers to drive innovation in biological research  PHYS.ORG · 22 hours
When sparks fly to innovate new technologies for imaging life at the microscopic scale, often diverse researchers are nudging each other with a kind... more
Scientists probe how distinct liquid organelles in cells are created  PHYS.ORG · 23 hours
The interior of a human cell consists, in part, of a complex soup of millions of molecules. more
Scientists unlock secrets of maternal/fetal cellular communication during pregnancy  SCIENCE DAILY · 23 hours
Researchers have unlocked mysteries surrounding how a pregnant mother's cells and her fetus' cells communicate throughout pregnancy. With this new information, scientists can develop new non-invasive methods of monitoring and... more
[Research Articles] The autophagy-activating kinase ULK1 mediates clearance of free {alpha}-globin in {beta}-thalassemia  Science Magazine · 24 hours
In β-thalassemia, accumulated free α-globin forms intracellular precipitates that impair erythroid cell maturation and viability. Protein quality control systems mitigate β-thalassemia pathophysiology... more
[Focus] Neoantigen quality, not quantity  Science Magazine · 24 hours
Prioritizing expressed clonal neoantigens in genes required for cancer cell survival may reduce the likelihood of resistance to neoantigen therapies. more
[Editors' Choice] Alternative rhythms in schizophrenia  Science Magazine · 24 hours
A distinct set of rhythmically expressed genes related to mitochondrial function is identified in the brains of patients with schizophrenia. more
Highest-resolution human brain 'parts list' to date lays road map to better treatments  SCIENCE DAILY · 1 day
A new study has written the most detailed 'parts list' of the human brain to date. This categorization of our brain cell... more
Discriminative T cell recognition of cross-reactive islet-antigens is associated with HLA-DQ8 transdimer-mediated autoimmune diabetes  Science Magazine · 1 day
Human leukocyte antigen (HLA)–DQ8 transdimer (HLA-DQA1*0501/DQB1*0302) confers exceptionally high risk in autoimmune diabetes. However, little is known about HLA-DQ8 transdimer–restricted... more
Aging promotes reorganization of the CD4 T cell landscape toward extreme regulatory and effector phenotypes  Science Magazine · 1 day
Age-associated changes in CD4 T-cell functionality have been linked to chronic inflammation and decreased immunity. However, a detailed... more
Quantitative prediction of erythrocyte sickling for the development of advanced sickle cell therapies  Science Magazine · 1 day
Sickle cell disease is induced by a mutation that converts normal adult hemoglobin to sickle hemoglobin (HbS) and engenders intracellular polymerization of... more
Numerical operations in living cells by programmable RNA devices  Science Magazine · 1 day
Integrated bioengineering systems can make executable decisions according to the cell state. To sense the state, multiple biomarkers are detected and processed via logic gates with synthetic biological devices. However,... more
Viruses mobilize plant immunity to deter nonvector insect herbivores  Science Magazine · 1 day
A parasite-infected host may promote performance of associated insect vectors; but possible parasite effects on nonvector insects have been largely unexplored. Here, we show that Begomovirus, the largest genus of... more
Off-on switching of enzyme activity by near-infrared light-induced photothermal phase transition of nanohybrids  Science Magazine · 1 day
The off-on manipulation of enzyme activity is a challenging task. We report a new strategy for reversible off-on control of enzyme activity... more
Dysregulation of ectonucleotidase-mediated extracellular adenosine during postmenopausal bone loss  Science Magazine · 1 day
Adenosine and its receptors play a key role in bone homeostasis and regeneration. Extracellular adenosine is generated from CD39 and CD73 activity in the cell membrane, through conversion of adenosine... more
Newly-Discovered Microbe Turns Oil into Methane  SCI-NEWS.COM · 1 day
Methanoliparia, a species of archaea from deep-sea oil seeps of the Gulf of Mexico, splits long-chain hydrocarbons into methane and carbon dioxide, according to... more
Why initial UTIs increase susceptibility to further infection  SCIENCE DAILY · 1 day
Researchers have discovered that an initial UTI can set the tone for subsequent infections. In mouse studies, the researchers found that a transient infection triggers a short-lived inflammatory response that rapidly eliminates... more
In cystic fibrosis, lungs feed deadly bacteria  SCIENCE DAILY · 1 day
A steady supply of its favorite food helps a deadly bacterium thrive in the lungs of people with cystic fibrosis, according to a new study. more
Researchers convert pro-tumor macrophages into cancer killers  SCIENCE DAILY · 1 day
Researchers identified a new therapeutic approach in mouse models that halts drug resistance and cancer progression by using an antibody that induces the immune system via macrophages to seek and kill cancer cells. more
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