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Gene drive technologies for ecosystem conservation: Use with care!
SCIENCE DAILY Scientists working in the vanguard of new genetic technologies have issued a cautionary call to ensure that possible applications in conservation will only affect local populations. Experts have now examined... 17 hours
Measuring quantitative effects of methylation on transcription factor-DNA binding affinity
Science Magazine Methylation of CpG (cytosine-phosphate-guanine) dinucleotides is a common epigenetic mark that influences gene expression. The effects of methylation on transcription factor (TF) binding are unknown for most TFs... 20 hours
Could this protein protect people against coronary artery disease?
SCIENCE DAILY The buildup of plaque in the heart's arteries is an unfortunate part of aging. But by studying the genetic makeup of people who maintain clear arteries into old age, researchers... 20 hours
Environmental factors may trigger lupus onset, progression
SCIENCE DAILY While genetics play a role in the development of Lupus, a systemic autoimmune disease, so do environmental triggers, such as particulates in air pollution and ultraviolet light, says a researcher. 21 hours
Finding allows gene editing with surgical precision
SCIENCE DAILY A more precise and efficient technology has been created to edit the genomes of living organisms, an ability that is transforming medicine and biotechnology. The new method eliminates some of the drawbacks of genome... 21 hours
Gene discovery may halt worldwide wheat epidemic
SCIENCE DAILY A gene that enables resistance to a new devastating strain of stem rust, a fungal disease that is hampering wheat production throughout Africa and Asia and threatening food security worldwide, has been identified by... 21 hours
Experts: Idaho hatchery built to save salmon is killing them
PHYS.ORG Fisheries biologists in Idaho say they think they know why a relatively new $13.5 million hatchery intended to save Snake River sockeye salmon from extinction is instead killing... 22 hours
Researchers identify possible genetic basis for coronary artery disease
NEWS MEDICAL The buildup of plaque in the heart's arteries is an unfortunate part of aging. But by studying the genetic makeup of people who maintain clear arteries into old age, researchers... 1 day
CRISPR patent wars highlight problem of granting broad intellectual property rights for tech that offers public benefits
PHYS.ORG (Phys.org)—Duke University Law professor Arti Rai and bio-technology professor Robert Cook-Deegan with Arizona State... 1 day
Australia is a global top-ten deforester – and Queensland is leading the way
PHYS.ORG When you think of devastating deforestation and extinction you usually think of the Amazon, Borneo and the Congo. But eastern Australia ranks... 1 day
Study refutes theory linking cognition, genes and income
PHYS.ORG Researchers have cast doubt on a widely-held belief that connects family income with cognitive development, according to a new study published in Proceedings of the National Academy of Sciences. 1 day
Team discovers new mechanisms for DNA stability
PHYS.ORG Researchers from the University of Seville at the Andalusian Centre for Molecular Biology and Regenerative Medicine have discovered that in eukaryotic cells, the proximity of the genes to the pores in the nuclear membrane... 1 day
Rare Gene Mutation Linked to Longer Lifespan in Amish
SCI-NEWS.COM A rare loss-of-function mutation in a gene called SERPINE1 identified among Old Order Amish in Indiana is associated... 1 day
Environmental triggers may play role in development of Lupus
NEWS MEDICAL While genetics play a role in the development of Lupus, a systemic autoimmune disease that can attack any organ system in the human body, so do environmental triggers, such as... 2 days
Study explores reasons for underrepresentation of minorities in genetic cancer research
NEWS MEDICAL Socio-cultural and clinical factors as well as healthcare processes were important drivers of a woman's willingness to provide saliva specimens for future cancer research. 2 days
Passenger pigeon genome shows effects of natural selection in a huge population
SCIENCE DAILY The passenger pigeon is famous for the enormity of its historical population and for its rapid extinction in the face of mass slaughter by... 2 days
Current CRISPR gene drives are too strong for outdoor use, studies warn
SCIENCE-NEWS Self-limiting genetic tools already in development may be able to get around concerns surrounding the use of gene drives. 2 days
Kill switches for engineered microbes gone rogue
SCIENCE DAILY Stable autonomous kill switches ensure biocontainment of living microbes designed as devices for medicine or the environment. New research outlines two new types of kill switches that address these challenges. The new kill switches... 2 days
Four billion passenger pigeons vanished. Their large population may have been what did them in
Science Magazine Low genetic diversity and poor adaptability meant this once ubiquitous bird could not recover from overhunting 2 days
Vasohibins encode tubulin detyrosinating activity
Science Magazine Tubulin is subjected to a number of posttranslational modifications to generate heterogeneous microtubules. The modifications include removal and ligation of the carboxy-terminal tyrosine of -tubulin. Whereas enzymes for most modifications have been assigned, the enzymes responsible for detyrosination,... 2 days
Structural basis of bacterial transcription activation
Science Magazine In bacteria, the activation of gene transcription at many promoters is simple and only involves a single activator. The cyclic adenosine 3',5'-monophosphate receptor protein (CAP), a classic activator, is able to activate transcription independently through two... 2 days
Mutation for microcephaly
Science Magazine 2 days
Genetics of the passenger pigeon
Science Magazine 2 days
Evolution of flower color pattern through selection on regulatory small RNAs
Science Magazine Small RNAs (sRNAs) regulate genes in plants and animals. Here, we show that population-wide differences in color patterns in snapdragon flowers are caused by an inverted... 2 days
A single mutation in the prM protein of Zika virus contributes to fetal microcephaly
Science Magazine Zika virus (ZIKV) has evolved into a global health threat because of its unexpected causal link to microcephaly. Phylogenetic analysis... 2 days
Natural selection shaped the rise and fall of passenger pigeon genomic diversity
Science Magazine The extinct passenger pigeon was once the most abundant bird in North America, and possibly the world. Although theory predicts that large populations will... 2 days
Passenger pigeon genome shows effects of natural selection in a huge population
PHYS.ORG The passenger pigeon is famous for the enormity of its historical population in North America (estimated at 3 to 5 billion) and for its... 2 days
Gene drive technologies for ecosystem conservation: Use with care
PHYS.ORG Scientists working in the vanguard of new genetic technologies have issued a cautionary call to ensure that possible applications in conservation will only affect local populations. In an article publishing... 2 days
Gene discovery may halt worldwide wheat epidemic
PHYS.ORG University of California, Davis, researchers have identified a gene that enables resistance to a new devastating strain of stem rust, a fungal disease that is hampering wheat production throughout Africa and Asia and threatening... 2 days
Kill switches for engineered microbes gone rogue
PHYS.ORG Synthetic biologists are fitting the genomes of microorganisms with synthetic gene circuits to break down polluting plastics, non-invasively diagnose and treat infections in the human gut, and generate chemicals and nutrition on long haul... 2 days
Team's advance allows gene editing with surgical precision
PHYS.ORG Yale researchers report they have created a more precise and efficient technology to edit the genomes of living organisms, an ability that is transforming medicine and biotechnology. The new method, described Nov.... 2 days
Microbial resident enables beetles to feed on a leafy diet
PHYS.ORG An international team including researchers from the Max Planck Institute for Chemical Ecology has described a bacterium residing in a species of leaf beetles which has an unexpected... 2 days
New procedures for DNA stability
SCIENCE DAILY In eukaryotic cells the proximity of the genes to the nuclear pores, which are found in the nuclear membrane, contributes to maintaining the integrity of the genome. This is due to the fact that the anchoring of DNA... 2 days
CRISPR shows potential to reduce diseases spread by mosquitoes
NEWS MEDICAL Research at the University of California, Riverside, have shown that it is possible for transgenic mosquitos to stably express the Cas9 enzyme in their germline. Cas9 addition will allow the... 2 days
Medical News Today: Obesity: Five surprising facts
MNT Obesity rates are on the rise. But did you know that weight gain tends to sneak up, and that our diet influences our children's genes? 2 days
New research shows how a gene can fuel obesity in mice
NEWS MEDICAL Obesity is often attributed to a simple equation: People are eating too much and exercising too little. But evidence is growing that at least some of... 2 days
Genomic study explores evolution of gentle 'killer bees' in Puerto Rico
PHYS.ORG A genomic study of Puerto Rico's Africanized honey bees - which are more docile than other so-called "killer bees" - reveals that they retain most of... 2 days
Aging tests disagree with one another
NEWS MEDICAL Whether it's an on-line quiz, a $300 chromosome test or an $800 blood panel, a lot of people seem to be interested in whether they're aging faster or slower than their chronological age would suggest. 2 days
Genetic diversity of tumor tissues can be barrier to precision medicine in gastric and esophageal cancers
NEWS MEDICAL A new study focused on describing genetic variations within a primary tumor, differences between the primary... 3 days
Aging tests yield varying results
SCIENCE DAILY A lot of people seem willing to spend hundreds to find out whether they're aging faster or slower than their chronological age would suggest. Unfortunately, they're just going to have to wait and see. A head-to-head comparison of... 3 days
Does this one gene fuel obesity?
SCIENCE DAILY Variants in a gene called ankyrin-B – carried by millions of Americans – could cause people to put on pounds through no fault of their own, new research demonstrates. 3 days
Risk perception of genome editing: Reservations and a great demand for information
SCIENCE DAILY For decades now, humans have been altering the genetic information of plants and animals in order to produce new varieties or strains. Some more... 3 days
A human has been injected with gene editing tools to cure his disabling disease. Here’s what you need to know
Science Magazine What’s new and not so new about clinical... 3 days
Couples sue fertility clinic over eggs with genetic defect
ABC NEWS 2 couples that gave birth to children with a genetic defect later traced back to donated eggs are suing a New York fertility doctor and his clinic 3 days
Microbiome transplants provide disease resistance in critically-endangered Hawaiian plant
SCIENCE DAILY A team of researchers transplanted microbes to restore the health of a critically endangered Hawaiian plant that, until now, had been driven to extinction in the wild and only survived... 3 days
Why these Amish live longer and healthier: An internal ‘Fountain of Youth’
SCIENCE DAILY The first genetic mutation that appears to protect against multiple aspects of biological aging in humans has been discovered in an extended family of... 3 days
Wider sampling of tumor tissues may guide drug choice, improve outcomes
SCIENCE DAILY By focusing on genetic variations within a primary tumor, differences between the primary and a metastatic tumor, and additional diversity from tumor DNA in the blood... 3 days
A null mutation in SERPINE1 protects against biological aging in humans
Science Magazine Plasminogen activator inhibitor–1 (PAI-1) has been shown to be a key component of the senescence-related secretome and a direct mediator of cellular senescence. In murine models... 3 days
[Editors' Choice] Epilepsy clocks in
Science Magazine Circadian CLOCK gene expression is reduced in human epileptic brain tissue, and its deletion is epileptogenic in mice. 3 days
[Research Articles] PD-L1 genetic overexpression or pharmacological restoration in hematopoietic stem and progenitor cells reverses autoimmune diabetes
Science Magazine Immunologically based clinical trials performed thus far have failed to cure type 1 diabetes... 3 days
[Research Resources] A method of high-throughput functional evaluation of EGFR gene variants of unknown significance in cancer
Science Magazine Numerous variants of unknown significance (VUS) have been identified through large-scale cancer genome projects,... 3 days
Mutation in blood clotting gene may extend human life span
Science Magazine Study of Amish community suggests that alteration protects against age-related diseases 3 days
Key to unlock blocked differentiation in microRNA-deficient embryonic stem cells
SCIENCE DAILY Scientists have partly solved a long-unanswered basic question about stem cells -- why are pluripotent stem cells that have mutations to block the production of microRNAs unable to... 3 days
Scientists find key that allows neural differentiation of microRNA-deficient pluripotent stem cells
NEWS MEDICAL The more than 200 different types of human cells have the same DNA but express different ensembles of genes. Each cell type was derived... 3 days
Defects in cell's 'waste disposal system' linked to Parkinson's
SCIENCE DAILY Research points at a group of lysosomal storage disorder genes as potential major contributors to the onset and progression of Parkinson's disease. 3 days
'Left-handed' fish and asymmetrical brains
SCIENCE DAILY Biologists have discovered the relationship between “handedness”, brain structure and genes in extremely specialized cichlid fish. 3 days
Mutated frog gene repels predators
PHYS.ORG Post-doctoral researcher Andrés Posso-Terranova and his former supervisor José Andrés have found evidence that a single gene called MC1R controls the deep black color on the skin of these poisonous frogs. The researchers have found that the disruption... 3 days
Scientist calls on public to help 'unlock' genes of threatened bat species
PHYS.ORG A University of Southampton scientist is calling on the public's help in her bid to unlock the genetic secrets of an endangered bat species. 3 days
Researchers visualize mechanism of CRISPR-Cas9 genetic-engineering technique
NEWS MEDICAL Researchers at Kanazawa University and the University of Tokyo report in Nature Communications the visualization of the dynamics of ‘molecular scissors’ — the main mechanism of the CRISPR-Cas9 genetic-engineering technique. 3 days
Medical News Today: There is such a thing as 'fault-free obesity,' after all
MNT New research shows how a genetic mutation may lead to obesity by increasing the size of the body's fat cells and making... 3 days
Finding a key to unlock blocked differentiation in microRNA-deficient embryonic stem cells
PHYS.ORG The more than 200 different types of human cells have the same DNA but express different ensembles of genes. Each cell type was derived... 3 days
Changes in multiple different genes drive world's most deadly forms of lung cancer
NEWS MEDICAL A new UC San Francisco–led study challenges the dogma in oncology that most cancers are caused by one dominant "driver" mutation that... 3 days
Tulane professor wins Department of Defense grant for research into arteriovenous malformations
NEWS MEDICAL Tulane University's Stryder Meadows, a cell and molecular biology professor, received a $1.7 million grant from the Department of Defense to study how arteriovenous... 3 days
Nanoparticles carrying CRISPR gene editing tools for genetic modifications
NEWS MEDICAL Researchers from MIT have now developed nanoparticles that could carry CRISPR genetic editing systems deep within the cells and perform their functions on the DNA. The paper was published in... 3 days
UCR researchers develop transgenic mosquitoes to help reduce spread of infectious diseases
NEWS MEDICAL Researchers at the University of California, Riverside have developed transgenic mosquitoes that stably express the Cas9 enzyme in their germline. The addition of Cas9... 4 days
Study points at lysosomal storage disorder genes as potential key contributors to Parkinson's
NEWS MEDICAL An international study has shed new light on the genetic factors associated with Parkinson's disease, pointing at a group of lysosomal storage... 4 days
Making mosquitoes self-destruct
PHYS.ORG Researchers at the University of California, Riverside have developed transgenic mosquitoes that stably express the Cas9 enzyme in their germline. The addition of Cas9 will enable the use of the CRISPR gene editing tool to make efficient, targeted changes to... 4 days
Scientists create yellow, three-eyed, wingless mosquitoes by using gene editing tool
SCIENCE DAILY Researchers have developed transgenic mosquitoes that stably express the Cas9 enzyme in their germline. The addition of Cas9 will enable the use of the CRISPR gene... 4 days
Microbiome transplants provide disease resistance in critically-endangered Hawaiian plant
PHYS.ORG Transplanting wild microbes from healthy related plants can make a native Hawaiian plant healthier and likelier to survive in wild according to new research from The Amend Laboratory in the... 4 days
Genetically Modified Beetles Grow Working Third Eye
LIVE SCIENCE A genetic tweak has led to the development of scarab beetles with an extra set of compound eyes in the middle of their heads, and the eyes actually work. 4 days
Sensor for the most important human cancer gene
SCIENCE DAILY The molecular smoke detector works like a TP53 sensor, which monitors the correct function of the gene. A non-functional TP53 gene is going to activate the sensor, which initiates cell death. 4 days
Dresden researchers develop molecular smoke alert for key human cancer gene
NEWS MEDICAL If it burns in a house smoke detectors alert us hence protecting life. A molecular smoke alert has now been developed by Dresden researchers for the... 4 days
3d printed metal mutants arise from europe s amaze programme 3D printed metal mutants arise from Europe’s AMAZE programme
ESA VIDEO Europe’s lead in metal 3D printing has been strengthened by the four-year AMAZE programme, producing lighter, cheaper, organically... 4 days
Researchers use novel computational tool to understand complex disease processes
NEWS MEDICAL Hypertension and heart disease arise from many contributing and interacting factors: genetics, food, and exercise, as well as problems with heart, liver, or kidney function. 4 days
Gene variants appear to alter features of alcohol dose-response relationship
NEWS MEDICAL Although estimates vary, scientists believe that 50 to 64 percent of the risk of alcohol use disorders (AUDs) is inherited. One way to identify this risk is through... 4 days
Specific way of spelling out genetic code likely allows viruses to evade our cellular defenses
NEWS MEDICAL For millions of years, humans and viruses have engaged in a constant tug of war: as our cells... 5 days
Epigenetic editing in healthy breast cells can set off chain reaction for tumor initiation
NEWS MEDICAL Changing the epigenetic code of a single gene is enough to cause a healthy breast cell to begin a chain... 5 days
Geologists uncover Antarctica’s fossil forests
SCIENCE DAILY Prehistoric polar forests were built for survival, but were not hardy enough to live in ultra-high concentrations of atmospheric carbon dioxide. A geologist is studying the tree fossil record in Antarctica from a mass extinction 250 million years... 5 days
Gene prompts cells to store fat, fueling obesity
SCIENCE DAILY Obesity is often attributed to a simple equation: people are eating too much and exercising too little. But evidence is growing that at least some weight gain is predetermined. New research suggests... 5 days
Genes that hold the clues to bladder cancer and its treatment
SCIENCE DAILY Scientists have discovered the 'genetic signatures' of the most common form of bladder cancer -- and it could open up the possibility of better-targeted treatment. 5 days
Innovative genetic, cellular techniques help identify multiple disease targets
SCIENCE DAILY Advances in the use of CRISPR-Cas9 and human induced pluripotent stem cell technologies to identify novel therapeutic targets for neurological disorders such as schizophrenia and addiction have been highlighted by... 5 days
Epigenetic editing reveals surprising insights into early breast cancer development
SCIENCE DAILY Changing the epigenetic code of a single gene is enough to cause a healthy breast cell to begin a chain reaction and become abnormal, according to new research. 5 days
In the fight against viral infection, spelling counts
SCIENCE DAILY Scientists have discovered a peculiarity in the genetic code of HIV that might explain how this and other viruses evolved ways to dodge our immune system. The findings could make it possible... 5 days
Study finds genetic treatment for inherited retinal disorder
NEWS MEDICAL A new study presented at the 121st Annual Meeting of the American Academy of Ophthalmology (AAO) 2017, for the first time found a novel gene therapy that can improve the eyesight of... 5 days
Uncovering a reversible master switch for development
SCIENCE DAILY Scientists have identified a reversible 'master switch' on most developmental genes. The team unearthed this biological insight through studies in the fruit fly -- a powerful model organism for studying how human genes are... 5 days
CRISPR-carrying nanoparticles edit the genome
MIT New delivery system developed by MIT team deletes disease-causing genes and reduces cholesterol. 5 days
Uncovering a reversible master switch for development
PHYS.ORG In a paper published in Genes & Development, BWH principal investigator Mitzi Kuroda, PhD, and her team identified a reversible "master switch" on most developmental genes. The team unearthed this biological insight through studies... 5 days
CMU software assembles RNA transcripts more accurately
PHYS.ORG Computational biologists at Carnegie Mellon University have developed a more accurate computational method for reconstructing the full-length nucleotide sequences of the RNA products in cells, called transcripts, that transform information from a gene into... 5 days
CRISPR-carrying nanoparticles edit the genome
PHYS.ORG In a new study, MIT researchers have developed nanoparticles that can deliver the CRISPR genome-editing system and specifically modify genes in mice. The team used nanoparticles to carry the CRISPR components, eliminating the need to use viruses for... 5 days
Zipping DNA
PHYS.ORG ETH researchers have developed a method that allows large amounts of genetic information to be compressed and then decompressed again in cells. This could aid in the development of new therapies. 5 days
Genetic engineering mechanism visualized
SCIENCE DAILY Researchers report the visualization of the dynamics of 'molecular scissors' -- the main mechanism of the CRISPR-Cas9 genetic-engineering technique. 5 days
Biologists create beetle with functional extra eye
SCIENCE DAILY The creation of three-eyed beetles through a new technique will provides scientists a new way to investigate the genetic mechanisms behind the evolutionary emergence of new physical traits. 5 days
Scientists identify new genes needed by Streptococcus pyogenes to grow in human saliva
NEWS MEDICAL Scientific and veterinary research charity, the Animal Health Trust, in partnership with world-leading scientists at the Houston Methodist Research Institute, have identified... 5 days
Advances in genetic and stem cell techniques help identify therapeutic targets for neurological disorders
NEWS MEDICAL Research released today highlights advances in the use of CRISPR-Cas9 and human induced pluripotent stem cell technologies to identify novel therapeutic targets... 5 days
Mutant gene network in colon cancer identified
SCIENCE DAILY The principles of the gene network for colon tumorigenesis have been identified. The principles will be used to find the molecular target for effective anti-cancer drugs in the future. Further, this research gained attention... 7 days
Genetic treatment for blindness may soon be reality
SCIENCE DAILY Patients who had lost their sight to an inherited retinal disease could see well enough to navigate a maze after being treated with a new gene therapy. 7 days
Genes influence our eye movements, study shows
NEWS MEDICAL How we explore our world with our eyes can influence everything from social interaction to learning. In a study published in Current Biology researchers at Karolinska Institutet show that our eye movements are partly... 1 week
New gene therapy for blindness may soon be reality
NEWS MEDICAL Patients who had lost their sight to an inherited retinal disease could see well enough to navigate a maze after being treated with a new gene therapy, according to research... 1 week
Top stories: Creating the perfect wave—with science—and saving sick kids with gene-edited skin
Science Magazine This week’s top Science news 1 week
New bioresources for plant peptide hormones using gene editing technology
SCIENCE DAILY Peptide hormones are important growth regulators that play various roles in many organisms. Although the importance of genes that encode peptide hormones is broadly recognized, most peptides have... 1 week
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3D printed metal mutants arise from Europe’s AMAZE programme
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