A central goal of precision medicine is to predict disease outcomes and design treatments based on multidimensional information from afflicted cells and tissues. Cell morphology is an emergent readout of the molecular underpinnings of a cell’s functions and,... more
MicroRNAs, a class of transcripts involved in the regulation of gene expression, are emerging as promising disease-specific biomarkers accessible from tissues or bodily fluids. However, their accurate quantification from biological... more
Heightened secretion of protumorigenic effector proteins is a feature of malignant cells. Yet, the molecular underpinnings and therapeutic implications of this feature remain unclear.... more
Arthropod-borne viruses (arboviruses) are important human pathogens for which there are no specific antiviral medicines. The abundance of genetically distinct... more
Gliomas that express the mutated isoforms of isocitrate dehydrogenase 1/2 (IDH1/2) have better prognosis than wild-type (wt) IDH1/2 gliomas. However, how these mutant (mut)... more
The planarian flatworm is a simple animal with a mighty and highly unusual ability: it can regenerate itself from nearly every imaginable injury, including decapitation. These tiny worms can regrow... more
According to a new study led by Steeve Bonneville from the Université libre de Bruxelles, the first mushrooms evolved on Earth between 715 and 810 million years ago, 300 million years earlier than the... more
Certain types of domesticated wheat have complicated origins, with genetic contributions from wild and cultivated wheat populations on opposite sides of the Fertile Crescent. Terence Brown and colleagues at the University of Manchester report these findings in a... more
It is estimated that around 114,000 people disappeared throughout Spain during the Spanish Civil War and subsequent dictatorship. Unfortunately, eight decades on,... more
An international team led by Harvard Medical School scientists has produced the first genome-wide ancient human DNA sequences from west and central Africa. more
Experts' interest in utilizing gene editing for breeding crops has seen revolutionary growth. Meanwhile, people's awareness of food safety has also been increasing. To... more
A research team has identified a new function of a gene called huntingtin, a mutation of which underlies the progressive neurodegenerative disorder known as Huntington's Disease. Using genetic mouse models, they have discovered that... more
If you have just had knee, shoulder or hip surgery, you may want to take anti-inflammatories in the morning or at noon, but not at night. A new... more
A study has shown few differences in the profiles of genes that influence cognition between people with schizophrenia, bipolar disorder and the general population. This surprising finding could provide new insights into therapies designed... more
A team of researchers at CHU Sainte-Justine and Université de Montréal has shed light on the mechanisms that underlie a rare genetic condition by creating the... more
A team of researchers from Yncréa Hauts-de-France and Université de Tours, has found that the ranging behavior of free-range chickens can impact their motor self-regulation. In their paper... more
Foxtail millet is an annual grass grown widely as a cereal crop in parts of India, China and Southeast Asia. Milling the grain removes the hard outer layer, or bran, from the... more
As more and more large-scale human genome sequencing projects get completed, scientists have been able to trace with increasing confidence both the geographical movements and underlying genetic variation... more
Recycled and aged human urine can be used as a fertilizer with low risks of transferring antibiotic resistant DNA to the environment, according to new research from the... more
Researchers at the Case Western University School of Medicine say they have identified a previously unknown gene and associated protein which could potentially be suppressed to slow the advance of Alzheimer's disease. more
Researchers from the Faculty of Health and Medical Sciences have shown a possible link between a genetic variation and the widespread type of cardiac arrhythmia, atrial... more
A Duke University research team has identified a new function of a gene called huntingtin, a mutation of which underlies the progressive neurodegenerative disorder known as Huntington's Disease. more
George Mason University's Aarthi Narayanan, Associate Professor, College of Science and the National Center for Biodefense and Infectious Disease, and Remi Veneziano, Assistant Professor, Volgenau School of Engineering,... more
Our genome consists of 20,000 genes, all of which may be capable of triggering disease. It is estimated that there are 7,000 unknown genes that cause recessive genetic diseases resulting from mutations... more
A massive meteorite impact and extreme volcanic activity occurred around the same time that Earth's large dinosaurs went extinct. But, did the volcanic activity... more
Researchers have identified 107 genes that increase a person's risk of developing the eye disease glaucoma, and now developed a genetic test to detect those at... more
Genetic research in zebrafish has surprised the researchers behind the study. The results have the potential to change the prevalent perception of the cardiac disorder atrial fibrillation. more
The development of next-generation-sequencing (NGS) has enabled researchers to investigate genomes that might previously have been considered too complex or too expensive. Nevertheless, the analysis of complex plant genomes, which... more
A method for finding genes that spur tumor growth takes advantage of machine learning algorithms to sift through reams of molecular data collected from studies of cancer cell... more
A five-country research team coordinated by Germán J. de Valcárcel Gonzalvo, Professor of Optics at the University of Valencia, has developed a new theory —the coherent master equation— that describes the behavior of pulsed lasers based... more
New insights into how microbial life was quickly re-established following the mass extinction of the dinosaurs have been detailed for the first time by Curtin University-led research. more
Australia's bushfires and other climate change effects are devastating the habitats of critically endangered species and driving the native platypus towards extinction, according to surveys highlighting the country's vulnerability to rising temperatures. more
Prolonged drought and other effects of climate change are pushing Australia's unique platypus population towards extinction, scientists warned in a study published Monday. more
The lungs and placentas of fetuses in the womb -- as young as 11 weeks after conception -- already show a bacterial microbiome signature, which suggests that bacteria may colonize the lungs... more
Chemosensory epithelial cells (EpCs) are specialized cells that promote innate type 2 immunity and protective neurally mediated reflexes in the airway. Their effector programs and modes... more
This work establishes a means to exploit genetic networks to create living synthetic composites that change shape in response to specific biochemical or physical stimuli. Baker’s yeast embedded in a hydrogel forms a responsive material where cellular proliferation leads to... more
Genes determine around 80% of a person's height, but environmental factors can also affect it. This article looks at how people can increase their height during development. more
Using DNA, small silica particles, and carbon nanotubes, researchers of Karlsruhe Institute of Technology (KIT) have developed novel programmable nanocomposites that can be tailored to various applications and programmed to degrade quickly and gently. For medical applications, they can create... more
Few things related to science capture the imagination more than the magic of worlds past. This includes the origins of life, dinosaurs, mass extinctions, meteorite impacts, and the evolution of our species. Understanding the evolution of life is... more
Good news stories can be hard to come by in an era of extinction, but the steady improvement in the fortunes of the black rhino is one of those stories. more
New research shows soybean oil not only leads to obesity and diabetes, but could also affect neurological conditions like autism, Alzheimer's disease, anxiety, and depression. more
Researchers from St. Jude Children's Research Hospital and the Chinese Children's Cancer Group led the first randomized, Phase III clinical trial comparing targeted therapies for acute... more
A new study published in the journal PLOS Pathogens in January 2020 reports the development of mosquitoes that have been genetically modified to resist infection by several types of the dengue virus. This is the first... more
Females are born with a finite supply of eggs and with age the genetic quality of the eggs decline say researchers from Carnegie Institute. The study from researchers Marla Tharp, Safia Malki, and Alex... more
Epigenetic changes occur in the DNA of breast cancer cells that have developed a resistance to hormone therapy, an effective treatment for ER+ breast cancer, which... more
N6-methyladenosine (m6A) regulates stability and translation of messenger RNA (mRNA) in various biological processes. Here, we showed that knockout of the m6A writer Mettl3 or a nuclear reader... more
Inside a cell, tentacled vesicles shuttle cargo for sorting. DNA rearranges in the nucleus as stem cells differentiate into neurons. Neighboring neurons cling to one another through a web-like interface.... more
Volcanic activity did not play a direct role in the mass extinction event that killed the dinosaurs, according to an international, Yale-led team of researchers. It... more
The cause of the end-Cretaceous mass extinction is vigorously debated, owing to the occurrence of a very large bolide impact and flood basalt volcanism near the boundary. Disentangling their relative importance is... more
One great challenge in understanding the history of life is resolving the influence of environmental change on biodiversity. Simulated annealing and genetic algorithms were used to... more
The largest study of its kind analyzed genetic information from 3,444 families and found one single gene whose mutations may help explain the condition. more
A research team has discovered the first conclusive evidence that selection may also occur at the level of the epigenome -- a term that refers to an assortment of chemical... more
A new study shows that cancer-causing MLL gene may also push pluripotent stem cells to make hematopoietic stem cells, a strong step in the decades-long effort... more
The new study explores alpha-synuclein's basic properties, with a focus on a section of the protein known as the non-amyloidal component (NAC). The research was done on fruit fly larvae... more
Scientists and Engineers have used surface-emitting semiconductor lasers in data communications, for sensing, in FaceID and within augmented reality glasses. In a new report, Yong-Ho Ra and a research team in the departments of... more
Defects in tRNA biogenesis influence gene expression and are associated with many types of human diseases, such as cancer and neurological diseases. In his thesis, Fu Xu contributes to new knowledge about the factors that modulate... more
In terms of space organization, DNA has powers rivaling Marie Kondo. A strand of DNA that is two meters long intricately folds itself into a cell nucleus only 10 microns across. (One... more
Extinction, or the disappearance of an entire species, is commonplace. Species have been forming, persisting and then shuffling off their mortal coil since life began on... more
The University of Oklahoma has entered an agreement to develop a $9 million program of joint research with Universidad Nacional de San Agustin, one... more
A new study suggests that extremely rare, harmful genetic mutations present in healthy donors' stem cells -- though not causing health problems in the donors --... more
A woman's supply of eggs is finite, so it is crucial that the quality of their genetic material is ensured. New work elucidates a mechanism by which, even before birth, the body tries to eliminate egg... more
An organism's genome contains all of the information necessary for each of its cells and tissues to develop and function properly. Written in DNA, each individual gene encodes for something, whether it... more
Global climate change is going to drastically alter the environmental conditions for humans and nature. Animals and plants unable to cope with the new conditions are thus forced to shift their range... more
Oxford Gene Technology, A Sysmex Group Company, is excited to announce the launch of its SureSeq CLL + CNV Panel — the company’s latest high-quality, next-generation... more
Atrazine is one of the most widely used pesticides in North America. Researchers at the Institut National de la Recherche Scientifique (INRS) have developed a new method to degrade it that combines a new nanostructured material... more
One of the most fascinating and important properties of living cells is their capacity for self-organization. By talking to each other, cells can, among other things, determine where they are in relation... more
A woman's supply of eggs is finite, so it is crucial that the quality of their genetic material is ensured. New work from Carnegie's Marla Tharp, Safia Malki, and Alex Bortvin elucidates a mechanism by which,... more
Researchers say a gene known to be a biomarker of age plays a key role in age-associated functional and anatomical aging in mouse retinas, a finding that has... more
While immunotherapy holds great promise for combating cancer, the limited efficacy due to an immunosuppressive tumor microenvironment and systemic toxicity hinder the broader application of cancer... more
High alcohol consumption is a risk factor for morbidity and mortality, yet few genetic loci have been robustly associated with alcohol intake. Here, we use U.K.... more
Microglia and infiltrating macrophages are thought to orchestrate the central nervous system (CNS) response to injury; however, the similarities between these cells make it... more
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Genetics