Genetics
Salk researchers uncover new function of mitochondria  NEWS MEDICAL · 1 hour
Mitochondria, tiny structures present in most cells, are known for their energy-generating machinery. Now, Salk researchers have discovered a new function of mitochondria: they set off molecular alarms when cells are exposed to stress... more
DNA-Based ‘Clock’ Predicts Maximum Lifespan in Living and Extinct Vertebrates  SCI-NEWS.COM · 5 hours
A team of researchers at the Commonwealth Scientific and Industrial Research Organisation (CSIRO), Australia, has developed... more
Researchers identify novel genes associated with severity of peanut allergy  NEWS MEDICAL · 23 hours
Researchers at the Icahn School of Medicine at Mount Sinai have identified novel genes associated with the severity of peanut allergy, as well as ways in which these... more
International project to preserve genetic resources of birds  NEWS MEDICAL · 23 hours
The support is provided by the Russian Foundation for Basic Research and the Science and Innovation in East Asia Consortium. Kazan Federal University's partners are Mahidol University and Kumamoto University. more
Mitochondria are the 'canary in the coal mine' for cellular stress  SCIENCE DAILY · 1 day
Mitochondria, tiny structures present in most cells, are known for their energy-generating machinery. Now, researchers have discovered a new function of mitochondria: they set off molecular... more
Mitochondria are the 'canary in the coal mine' for cellular stress  PHYS.ORG · 1 day
Mitochondria, tiny structures present in most cells, are known for their energy-generating machinery. Now, Salk researchers have discovered a new function of mitochondria: they set off... more
How two experimental Alzheimer's drugs reverse aging  MNT · 2 days
New research in mice reveals the molecular and genetic mechanisms through which two Alzheimer's drug candidates can reverse aging in general. more
Neuroscientists develop new method for uniquely targeted gene therapy  NEWS MEDICAL · 2 days
Neuroscientists at Lund University in Sweden have developed a new technology that engineers the shell of a virus to deliver gene therapy to the exact cell type in the body... more
Points to consider: Should germline genetic testing be offered to all patients with breast cancer?  NEWS MEDICAL · 2 days
Should germline genetic testing be offered to all patients with breast cancer? The American College of Medical Genetics... more
RIT and IAR observe pulsars for the first time from South America  PHYS.ORG · 2 days
Rochester Institute of Technology and the Instituto Argentino de Radioastronomía (IAR) have collaborated to make the first pulsar observations from South America. more
The wild relatives of major vegetables, needed for climate resilience, are in danger  PHYS.ORG · 2 days
Growing up in the wild makes plants tough. Wild plants evolve to survive the whims of nature and thrive in difficult conditions,... more
Topology-dependent anomalous dynamics of ring and linear DNA are sensitive to cytoskeleton crosslinking  Science Magazine · 2 days
Cytoskeletal crowding plays a key role in the diffusion of DNA molecules through the cell, acting as a barrier to effective intracellular... more
Synthetic nanopores made from DNA  SCIENCE DAILY · 2 days
A scientific collaboration has resulted in the construction of a synthetic DNA nanopore capable of selectively translocating protein-size macromolecules across lipid bilayers. more
Medical News Today: How two experimental Alzheimer's drugs reverse aging  MNT · 2 days
New research in mice reveals the molecular and genetic mechanisms through which two Alzheimer's drug candidates can reverse aging in general. more
People willing to risk near-certain death for an HIV cure  SCIENCE DAILY · 2 days
People willing to risk near-certain death for an HIV cure; protecting individuals and families in genetic and psychiatric research, considerations for including pregnant women in research. more
Researchers create synthetic nanopores made from DNA  PHYS.ORG · 2 days
In 2015, the first commercial nanopore DNA sequencing device was introduced by Oxford Nanopore Technologies. Based on a synthetically engineered transmembrane protein, nanopore sequencing allows long DNA strands to be channelled through the central... more
Colliding molecules and antiparticles  PHYS.ORG · 2 days
Antiparticles—subatomic particles that have exactly opposite properties to those that make up everyday matter—may seem like a concept out of science fiction, but they are real, and the study of matter-antimatter interactions has important medical and technological applications. Marcos Barp... more
Researchers create synthetic nanopores made from DNA  nanowerk · 2 days
Researchers have constructed a synthetic DNA nanopore capable of selectively translocating protein-size macromolecules across lipid bilayers. more
Chimpanzees may have evolved resistance to HIV precursor  PHYS.ORG · 2 days
Simian immunodeficiency virus, the monkey- and ape-infecting virus that HIV originated from, may have influenced the genetics of chimpanzees, finds a new UCL-led study. more
Researchers find many psychiatric disorders share the same gene variants  NEWS MEDICAL · 2 days
An international team of researchers has found that many psychiatric disorders share a common and specific set of gene variants. more
Ancient DNA confirms humans wiped out northern hemisphere's version of the penguin  PHYS.ORG · 2 days
The North Atlantic was once home to a bird that bore a remarkable similarity to penguins. The great auk, also known as "the original... more
Study: The human lifespan is written into our DNA  PHYS.ORG · 2 days
Humans have a "natural" lifespan of around 38 years, according to a new method we have developed for estimating the lifespans of different species by analyzing their DNA. more
Horizon Discovery adds predesigned synthetic single guide RNA to its product range  NEWS MEDICAL · 2 days
Horizon Discovery Group plc, a global leader in the application of gene editing and gene modulation technologies, today announced the addition of predesigned synthetic... more
Human genetics evidence predictive of drug development success, study shows  NEWS MEDICAL · 2 days
A new drug candidate is more likely to be approved for use if it targets a gene known to be linked to the disease; a finding that can... more
Rosalind meets Rosalind  ESA · 2 days
Image: The work of Dr Rosalind Franklin (1920-1958) is well known for being central to the discovery of the iconic double-helix structure of DNA, the fabric of life as we... more
Medical News Today: Could epigenome editing prevent developmental disorders?  MNT · 2 days
Using mice, scientists show how epigenome editing has promise as a way to fix disordered brain development that arises from a WAGR syndrome gene mutation. more
ACMG recommends evaluations of breast cancer patients before genetic testing  NEWS MEDICAL · 3 days
According to a statement on behalf of the American College of Medical Genetics and Genomics (ACMG) published Dec. 13 in the organization's official journal, Genetics in Medicine, there... more
Precision epigenome editing can repair genetic syndrome of intellectual disability  NEWS MEDICAL · 3 days
Using a targeted gene epigenome editing approach in the developing mouse brain, Johns Hopkins Medicine researchers reversed one gene mutation that leads to the genetic disorder WAGR syndrome,... more
Supporting students in Puerto Rico after a hurricane’s devastation  MIT · 3 days
Postdoc Héctor De Jesús-Cortés works to build up the STEM pipeline from his homeland to MIT and beyond. more
Could epigenome editing prevent developmental disorders?  MNT · 3 days
Using mice, scientists show how epigenome editing has promise as a way to fix disordered brain development that arises from a WAGR syndrome gene mutation. more
Research suggests contributory role of 'Asian glow' mutation and alcohol to Alzheimer’s  NEWS MEDICAL · 3 days
A new study from Stanford, published on December 12 in the journal Acta Neuropathologica Communications, suggests that an important enzyme that helps break down... more
Scientists solve 3D structure of vaccinia virus RNA polymerase  NEWS MEDICAL · 3 days
For viruses to multiply, they usually need the support of the cells they infect. In many cases, only in their host's nucleus can they find the machines, enzymes and building... more
Your genes aren't the only factor dictating Alzheimer's risk  SCIENCE DAILY · 3 days
In the first study published about Alzheimer's disease among identical triplets, researchers found that despite sharing the same DNA, two of the triplets developed Alzheimer's while one did not. more
Depletion of microbiome-derived molecules in the host using Clostridium genetics  Science Magazine · 3 days
The gut microbiota produce hundreds of molecules that are present at high concentrations in the host circulation. Unraveling the contribution of each molecule to host biology remains difficult.... more
Geneticists identify small molecules that are potential indicators for disease  SCIENCE DAILY · 3 days
Researchers identified hundreds of metabolites that might serve as intermediates to translate variation in the genome to variation in complex traits. Findings could someday facilitate early or more... more
As epilepsy drugs fail nearly one-third of patients, scientists seek root causes of seizures  Science Magazine · 3 days
Leaps in gene sequencing and better animal models are changing how doctors understand, study, and sometimes treat epilepsy more
Virus multiplication in 3-D  PHYS.ORG · 3 days
For viruses to multiply, they usually need the support of the cells they infect. In many cases, only in their host's nucleus can they find the machines, enzymes and building blocks with which they can multiply their genetic material before... more
Chemists' calculations may advance cancer prediction  SCIENCE DAILY · 3 days
A computational study by chemists showed the dynamics of tumor formation don't necessarily correlate with clinical data on lifetime cancer risks. It suggests biomarkers may someday be able to help predict when mutations in cells will... more
Herpes's Achilles heel  SCIENCE DAILY · 3 days
Scientists have used the gene-editing tool CRISPR-Cas9 to disrupt both latent reservoirs of the herpes simplex virus and actively replicating virus in human fibroblast cells. Experiments pinpoint weak spot that can make the virus susceptible to gene editing. more
Carolina parakeet extinction was driven by human causes, DNA sequencing reveals  PHYS.ORG · 3 days
Researchers from the Institute of Evolutionary Biology (IBE, a joint institute of the Pompeu Fabra University (UPF) and the Spanish National Research Council (CSIC)) in Barcelona... more
Genetic 'clock' predicts lifespan in vertebrates  PHYS.ORG · 3 days
A model that uses genetic markers to accurately estimate the lifespans of different vertebrate species is presented in a study in Scientific Reports this week. The 'lifespan clock' screens 42 selected genes for CpG sites, short... more
Researchers discover cause of a previously unknown autoinflammatory disorder, CRIA syndrome  NEWS MEDICAL · 3 days
Researchers have identified the genetic cause of an autoinflammatory disease, CRIA, a previously unknown disorder. more
The 'right' whale to save  PHYS.ORG · 3 days
You may have heard that Earth's current sixth mass extinction stems from human causes, but what does this actually look like? I present to you Exhibit A: North Atlantic right whales (Eubalaena glacialis), a species disappearing at an... more
Researchers discover cause of a previously unknown autoinflammatory disorder  NEWS MEDICAL · 3 days
Researchers have identified the genetic cause of an autoinflammatory disease, CRIA, a previously unknown disorder. more
Around 35,000 years ago, Central Iberia had a tundra-steppe landscape  PHYS.ORG · 3 days
A study just published by the journal Quaternary Science Reviews, headed by Nohemi Sala, an expert on taphonomy at the Centro Nacional de Investigación sobre la Evolución Humana... more
Mass extinction of land and sea biodiversity 250 million years ago not simultaneous  PHYS.ORG · 3 days
Some 250 million years ago, simultaneous mass extinctions of marine and terrestrial life occurred in an event known as the End-Permian. Or... more
Epigenome editing could repair genetic brain disorder  NEWS MEDICAL · 4 days
A new study published in the journal Nature Communications shows that it may be possible to reverse gene mutations that cause brain disorders, using a very precisely targeted epigenome editing technique. This type of... more
Gut disease and gene analysis networks  NEWS MEDICAL · 4 days
Gut diseases are difficult to diagnose in many cases, and their underlying dysfunction is hard to understand in many cases. Now, a new study published in the journal Molecular Omics promises to uncover a better insight... more
Understanding Asteraceae: Validation of a Hyb-Seq probe set for evolutionary studies  PHYS.ORG · 4 days
Accurately reconstructing the relationships between different species requires analyzing the sequences of a judiciously selected, and preferably large, sample of different genes. Hybrid capture with high-throughput... more
Earth was stressed before dinosaur extinction  PHYS.ORG · 4 days
New evidence gleaned from Antarctic seashells confirms that Earth was already unstable before the asteroid impact that wiped out the dinosaurs. more
Genetic code doesn't dictate whether a person is guaranteed to develop Alzheimer's  NEWS MEDICAL · 4 days
The colour of our eyes or the straightness of our hair is linked to our DNA, but the development of Alzheimer's disease isn't exclusively... more
New human autoinflammatory disease  SCIENCE DAILY · 4 days
Scientists from Australia and the US have discovered and identified the genetic cause of a previously unknown human autoinflammatory disease. The researchers determined that the autoinflammatory disease, which they termed CRIA (cleavage-resistant RIPK1-induced autoinflammatory) syndrome, is caused by a mutation... more
Earth was stressed before dinosaur extinction  SCIENCE DAILY · 4 days
By measuring the chemistry of fossilized seashells collected in Antarctica, researchers discovered that Earth was already experiencing carbon cycle instability before the asteroid impact that wiped out the dinosaurs. more
Necrotizing enterocolitis is preceded by increased gut bacterial replication, Klebsiella, and fimbriae-encoding bacteria  Science Magazine · 4 days
Necrotizing enterocolitis (NEC) is a devastating intestinal disease that occurs primarily in premature infants. We performed genome-resolved metagenomic analysis of 1163 fecal... more
NS1 DNA vaccination protects against Zika infection through T cell-mediated immunity in immunocompetent mice  Science Magazine · 4 days
The causal association of Zika virus (ZIKV) with microcephaly, congenital malformations in infants, and Guillain-Barré syndrome in adults highlights the... more
Gastrointestinal transcription factors drive lineage-specific developmental programs in organ specification and cancer  Science Magazine · 4 days
Transcription factors (TFs) are spatially and temporally regulated during gut organ specification. Although accumulating evidence shows aberrant reactivation of developmental programs in cancer, little... more
Characterizing smoking-induced transcriptional heterogeneity in the human bronchial epithelium at single-cell resolution  Science Magazine · 4 days
The human bronchial epithelium is composed of multiple distinct cell types that cooperate to defend against environmental insults. While studies have shown that smoking... more
[Research Articles] Hair eruption initiates and commensal skin microbiota aggravate adverse events of anti-EGFR therapy  Science Magazine · 4 days
Epidermal growth factor receptor (EGFR)–targeted anticancer therapy induces stigmatizing skin toxicities affecting patients’ quality of life and therapy... more
Deep learning helps tease out gene interactions  SCIENCE DAILY · 4 days
Computer scientists have taken a deep learning method that has revolutionized face recognition and other image-based applications in recent years and redirected its power to explore the relationship between genes. more
Social media contributes to increased perception of food technology as risky business  PHYS.ORG · 4 days
When it comes to food technology, the information shared on social media often trumps the facts put out by the scientific community and food... more
There's a new squid in town  SCIENCE DAILY · 4 days
Researchers in OIST's Molecular Genetics Unit, in collaboration with a researcher from Australia, have identified a new species of bobtail squid inhabiting Okinawa's waters -- dubbed Euprymna brenneri. The scientists' findings, published in Communications Biology, highlight... more
Sorghum study illuminates relationship between humans, crops and the environment in domestication  SCIENCE DAILY · 4 days
A new study illustrates the concept of a domestication triangle, in which human genetics interact with sorghum genetics and the environment to influence the... more
Sustainable separation technology makes new applications possible  PHYS.ORG · 4 days
Membranes are widely used to separate substances from each other, for example in water treatment or kidney dialysis. Membrane technology saves energy and water, and has a small CO2 footprint. Unfortunately, large quantities of... more
MASS: An integrative software program for streamlined morphometric analyses of leaves  PHYS.ORG · 4 days
Analysis of leaf shape and size is a cornerstone of botany, and is crucial in answering a variety of ecological, evolutionary, genetic, and agricultural questions. However,... more
Rapid DNA identifies conception boat fire victims  PHYS.ORG · 4 days
Thirty-four people died in a tragic boat fire on September 2, 2019, off the coast of Santa Cruz Island, California. Five crew members escaped with injuries after calling for help, but the intense fire... more
DNA site GEDmatch sold to forensic genomics firm  NEWS MEDICAL · 4 days
A DNA site has been bought by a forensic genomics firm, prompting discussion over future use of genetic data in solving crime. more
Estimates of commercial fish biomass from DNA traces in seawater  PHYS.ORG · 4 days
A new study published by scientists from the Faroese Marine Research Institute reveals that traces of DNA left behind in seawater can be used to predict the biomass... more
Sorghum study illuminates relationship between humans, crops and the environment in domestication  PHYS.ORG · 4 days
A new study that examines the genetics behind the bitter taste of some sorghum plants and one of Africa's most reviled bird species illustrates... more
Stilla Technologies announces key leadership hires  NEWS MEDICAL · 4 days
Stilla Technologies, the provider of pioneering digital PCR solutions for high-precision genetic analysis, today announced three key hires: Khaled Bahi joins as CFO, with Jerome Leclercq named Senior Vice President for Commercial Operations Europe & Asia... more
OGT develops targeted NGS panel for constitutional cytogenetics research  NEWS MEDICAL · 4 days
Oxford Gene Technology, A Sysmex Group Company, has developed a breakthrough targeted NGS panel for constitutional cytogenetics research. The new CytoSure NGS panel—launching early in 2020—will combine the strengths of... more
Genetic variant mainly found in individuals of African ancestry increases odds of heart failure  NEWS MEDICAL · 5 days
A genetic variant in the gene transthyretin (TTR)- which is found in about 3 percent of individuals of African ancestry-... more
Online decision aid provides more knowledge about the benefits of genomic sequencing  NEWS MEDICAL · 5 days
A decision aid developed to support patients undergoing genomic sequencing can reduce the amount of time patients spend speaking with overburdened genetic counselors while... more
Genetic brain disorder fixed in mice using precision epigenome editing  SCIENCE DAILY · 5 days
Using a targeted gene epigenome editing approach in the developing mouse brain, researchers reversed one gene mutation that leads to the genetic disorder WAGR syndrome, which causes intellectual... more
Lower BMI means lower diabetes risk, even among non-overweight people  SCIENCE DAILY · 5 days
Lower body mass index (BMI) is consistently associated with reduced type II diabetes risk, among people with varied family history, genetic risk factors and weight, according to a... more
Modifier gene offers a likely explanation for less infection in some patients with cystic fibrosis  NEWS MEDICAL · 5 days
Cystic fibrosis is caused by an inherited mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. more
Gut feeling: A network approach towards understanding IBD  PHYS.ORG · 5 days
Diseases of the gut are often notoriously difficult to diagnose, nevermind understand, which is where a network-based approach comes in. Rather than trying to understand individual symptoms, or the role of individual... more
Improving the accuracy of climate model projections with emergent constraints  PHYS.ORG · 5 days
The increase in carbon dioxide concentration in the atmosphere has warmed the Earth since the beginning of the industrial era. Climate models try to project how much this... more
ERC promotes CRISPR research to better treat infections  NEWS MEDICAL · 5 days
Chase Beisel heads the "Synthetic Biology of RNA" research group at the Helmholtz Institute for RNA-based Infection Research (HIRI) in Würzburg, a branch of the Helmholtz Centre for Infection Research in Braunschweig... more
The genetic signature of memory  SCIENCE DAILY · 5 days
Despite their importance in memory, the human cortex and subcortex display a distinct collection of 'gene signatures.' The work increases our understanding of how the brain creates memories and identifies potential genes for further investigation. more
Increasing food intake by swapping mitochondrial genomes  SCIENCE DAILY · 5 days
To uncover the relationship between variation in genes and phenotypic diversity, geneticists use a set of fully sequenced fruit-fly genomes. But little is known about the variation in the mitochondrial genome, for which mutations... more
Transplant patient finds out his DNA has been replaced by that of his donor  NEWS MEDICAL · 5 days
A bone marrow transplant recipient later found out that the DNA in his blood and semen had been replaced by... more
New study uncovers the genetic basis of memory  NEWS MEDICAL · 5 days
New research has uncovered the genetic basis for different functions of memory. more
So-called junk DNA hides useful compounds  PHYS.ORG · 5 days
Bio-Protection Research Centre scientists and collaborators have made a discovery that potentially opens the door to new medicines and biological pesticides. more
To save koalas from fire, we need to start putting their genetic material on ice  PHYS.ORG · 5 days
Thousands of koalas may have died in fires burning through New South Wales but expert evidence to a... more
A new way to regulate gene expression  PHYS.ORG · 5 days
Sometimes, unexpected research results are simply due to experimental error. Other times, it's the opposite—the scientists have uncovered a new phenomenon that reveals an even more accurate portrayal of our bodies and our universe,... more
New tool predicts three-dimensional organization of human chromosomes  PHYS.ORG · 5 days
University of Wisconsin–Madison researchers have developed a computational tool that can accurately predict the three-dimensional interactions between regions of human chromosomes. more
Gene Therapy May Aid In Sickle Cell Disease Treatment  NPR · 5 days
Scientists report progress using gene therapy to treat sickle cell disease, a common and devastating genetic blood disorder. more
Brazil milks deadly snakes for their life-saving venom  PHYS.ORG · 6 days
Gripping the deadly snake behind its jaws, Fabiola de Souza massages its venom glands to squeeze out drops that will save lives around Brazil where thousands of people are bitten every year. more
Genetic alteration increases risk of Autism and Tourette's impacts on the brain  NEWS MEDICAL · 6 days
Lancaster University researchers have discovered, for the first time, how a genetic alteration that increases the risk of developing Autism and Tourette's impacts on... more
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