Nagano prefecture is home to a group of people effected with a rare genetic neurodegenerative disorder called familial amyloid polyneuropathies. This disease impacts the gene encoding protein transthyretin... more
The first 21 SARS-CoV-2 genomes in Austria have now been completed and published within the scope of the “Mutational Dynamics of SARS-CoV-2” project recently launched by CeMM, the... more
Patterned cell divisions require a precisely oriented spindle that segregates chromosomes and determines the cytokinetic plane. In this study, we investigated how the meiotic... more
Numerous plants and animals harbor selfish B chromosomes that "drive" or transmit themselves at super-Mendelian frequencies, despite long-term fitness costs to the organism. Currently, it is unknown how... more
Blue natural pigments are rare, especially among plants. However, flowering species that evolved to attract Hymenoptera pollinators are colored by blue anthocyanin-metal complexes. Plants lacking anthocyanins are pigmented by betalains but are... more
A protein analysis of an 800,000-year-old tooth suggests the supposed cannibal species Homo antecessor was only distantly related to humans and Neanderthals. more
Scientists have studied oscillating patterns of gene expression, coordinated across time and space within a tissue grown in vitro, to explore the molecular causes of a rare human hereditary disease known as spondylocostal dysostosis. more
The end-Permian mass extinction (EPME), approximately 252 million years ago (Ma), caused a serious marine and terrestrial ecosystem crisis, and about 75% of terrestrial... more
New artificial proteins have been created to function as molecular logic gates. Like their electronic counterparts in computers, these biochemical tools can be used to program the behavior of complex systems, such... more
A new study found that human-induced environmental stressors have a large effect on the genetic composition of coral reef populations in Hawai'i. They confirmed that there is an ongoing loss... more
New York City Mayor Bill de Blasio is calling for a national enlistment program for doctors and nurses to handle an expected surge in coronavirus cases in New York and other places... more
The Universitat Politècnica de València has led the development of a new mechanical ventilator, ready for a quick industrial production. It would provide hospitals with these... more
A new study by researchers at the University of Hawai'i at Mānoa School of Ocean and Earth Science and Technology (SOEST) found that human-induced environmental stressors have a large effect... more
The success of poly(ADP-ribose) polymerase–1 (PARP-1) inhibitors (PARPi) to treat cancer relates to their ability to trap PARP-1 at the site of a DNA break. Although different forms of PARPi... more
Understanding the extinction of Australopithecus and origins of Paranthropus and Homo in South Africa has been hampered by the perceived complex geological context of hominin fossils,... more
The design of modular protein logic for regulating protein function at the posttranscriptional level is a challenge for synthetic biology. Here, we describe the design of two-input AND, OR, NAND, NOR, XNOR, and NOT... more
Genetic variations in the skin can create a natural sunscreen, according to University of Queensland researchers investigating the genes linked with vitamin D. more
Branching allows plants to occupy space in three dimensions, an innovation considered essential for their adaption. Stem cells are key to this process because they promote the establishment of new growth axes. But where do these... more
Turbulent flows are chaotic yet feature universal statistical properties.Over the recent years, seemingly turbulent flows have been discovered in active fluids such as bacterial suspensions, epithelial cell monolayers, and mixtures of biopolymers... more
Biogazelle NV, a CRO specialized in RNA analytics, has announced the initiation of large-scale testing of patient samples for SARS-CoV-2. Biogazelle is providing one of the multiple testing sites in... more
An analysis of a large Swedish cohort revealed that breast density, microcalcifications, and masses are heritable features, and that breast density and microcalcifications were positively associated with a... more
A new study in Nature Communications proposes a method to extend polygenic scores, the estimate of genetic risk factors and a cornerstone of the... more
Viruses are tiny bundles of DNA or RNA which have the ability to infect host cells, hijack the machinery of the host cell and then replicate. Once the host cell’s resources are exhausted, the... more
The Healthy Nevada Project, a first-of-its-kind, community-based population health study combining genetic, clinical, environmental and social data, offers free genetic testing to every Nevadan... more
Rutgers' RUCDR Infinite Biologics has launched a test for the SARS-CoV-2 coronavirus and is using its automation experience and infrastructure to test as many as tens of thousands... more
Researchers from the University of British Columbia and the Central South University in China have for the first time identified a gene that increases the risk of Alzheimer's disease. more
Investigators at St. Jude Children's Research Hospital, the European Molecular Biology Laboratory, and the German Cancer Research Center have identified ELP1 as a novel predisposition gene in the SHH subgroup... more
In recent years, scientists have uncovered evidence that modern humans and Neanderthals share a tangled past. In the course of human history, these two species of hominins interbred... more
A new study reinforces the concept that Neanderthal DNA has been woven into the modern human genome on multiple occasions as our ancestors met Neanderthals time and again... more
Cells will ramp up gene expression in response to physical forces alone, a new study finds. Gene activation, the first step of protein production, starts less than one millisecond after a cell... more
A study published in Science Advances on April 1 reveals a new hypothesis that may explain why European cave bears went extinct during past climate change... more
Although growth factors have great therapeutic potential because of their regenerative functions, they often have intrinsic drawbacks, such as low... more
The potassium channel Kv7.1 associates with the KCNE1 regulatory subunit to trigger cardiac IKs currents. Although the Kv7.1/KCNE1 complex has received much attention, the subcellular compartment hosting the assembly is the subject of ongoing debate. Evidence... more
The causes of 40% of all cases of certain medulloblastomas -- dangerous brain tumors affecting children -- are hereditary. A genetic defect that occurs in 15% of these children plays a key role by destabilizing the production of... more
Genetic information from an 800,000-year-old human fossil has been retrieved for the first time. The results shed light on one of the branching points in the human family... more
Scientists have mapped the genome of the German shepherd, one of the world's most popular canine breeds, after using a blood sample from 'Nala,' a healthy... more
As requested by the Austrian Federal Government and the WHO, a significant increase in the capacity for coronavirus testing is essential to combat the new coronavirus. The University of Innsbruck is now responding to this by immediately developing... more
Genetic information from an 800,000-year-old human fossil has been retrieved for the first time. The results from the University of Copenhagen shed light on one of the branching points in... more
Thermo Fisher Scientific, the world leader in serving science, today announced the availability of the Thermo Scientific AcroMetrix Coronavirus 2019 (COVID-19) RNA Control, its latest quality... more
In an ongoing effort to detect endangered Bryde's whales, the National Oceanic and Atmospheric Administration (NOAA) and MBARI have teamed up to deploy an Environmental Sample... more
A team of U.S. researchers has discovered a genetic mutation that improves cognitive flexibility in mice. Electrical signals stimulate chemical... more
Genetic studies of attention-deficit/hyperactivity disorder (ADHD) show that it takes many common genetic variations combining together in one individual to increase risk substantially. more
Three previously unknown genetic mechanisms have been discovered in causing myopia otherwise known as short or near-sightedness, finds a new study. more
Z-form nucleic acids are double-stranded DNA and RNA molecules with an unusual left-handed double helix structure, as opposed to the classical right-handed Watson-Crick double helix. Z-nucleic... more
Stellenbosch University in South Africa and AzarGen Biotechnologies (Pty) Ltd, a South African biotechnology company focused on developing human therapeutic proteins using advanced genetic engineering and synthetic biology... more
Researchers at the University of California San Diego discovered that high blood levels of RNA produced by the PHGDH gene could serve as a biomarker for early detection... more
Researchers at the National Institutes of Health have discovered a second gene that causes melorheostosis, a rare group of conditions involving an often painful and disfiguring overgrowth of bone tissue. more
Researchers describe their discovery of a new mechanism that could contribute to the pathogenesis of inflammatory diseases. The scientists found that ZBP1,... more
Synthetic biology, and particularly DNA synthesis, is transforming diagnosis and treatment of disease, and may yet play a key role in halting the COVID-19 pandemic. more
Cobra Biologics, an international CDMO for biologics and pharmaceuticals, and the Karolinska Institutet, one of the world’s leading medical universities, today announced... more
We all know that habitat loss is pushing many species to the brink of extinction, with the conversion of forests for agricultural use a particular problem. more
A particular group of non-coding RNAs (ncRNAs) known as microRNAs (miRNAs) are ~22 nucleotide (nt) in length and play vital roles in diverse physiological... more
Identification of differentially expressed genes (DEGs) is a fundamental step for many biomedical studies. RNA-sequencing is the most popular approach for this purpose and is widely... more
Tropical rainforests are emptying out due to the ongoing extinction of animal species caused by overhunting and forest fragmentation. But not only species as such, also the number... more
Researchers have developed a blood test that could accurately detect up to 50 types of cancers, and some of these detections could be even before the... more
Genetics researchers say a new approach could benefit all sorts of serious health conditions, and they're urging scientists to quickly pluck 'low hanging fruit' for the... more
Scientists have identified a new control mechanism that enables stem cells to adapt their activity in emergency situations. For this purpose, the stem cells simultaneously modify the blueprints for hundreds of proteins encoded in the gene transcripts. In... more
Scientists from the German Cancer Research Center (DKFZ) and the Heidelberg Institute of Stem Cell Technology and Experimental Medicine (HI-STEM) and the Max Planck Institute in Freiburg have identified a new control mechanism that enables stem cells to... more
A study by the Human Evolutionary Biology Group at the UPV/EHU-University of the Basque Country provides clues about the prevalence of a certain genetic profile in... more
Researchers from the Zuckerman Institute at Columbia University have successfully found a gene that could work towards accelerating the progression of ALS or amyotrophic lateral sclerosis. The study titled, "The... more
Researchers at the National Institutes of Health have discovered in mice what they believe is the first known genetic mutation to improve cognitive flexibility--the ability to adapt to changing situations. more
Columbia scientists have provided new insights into how mutations in a gene called TBK1 cause amyotrophic lateral sclerosis, a progressive neurodegenerative disease... more
A piece of research by the Human Evolutionary Biology Group at the UPV/EHU-University of the Basque Country provides clues about the prevalence of a... more
Gene therapy investigators can greatly benefit from the resources and services provided by the National Gene Vector Biorepository, housed at the Indiana University School of Medicine. more
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Genetics