Genetics
Single-cell morphology encodes metastatic potential  Science Magazine · 42 minutes
A central goal of precision medicine is to predict disease outcomes and design treatments based on multidimensional information from afflicted cells and tissues. Cell morphology is an emergent readout of the molecular underpinnings of a cell’s functions and,... more
Isothermal digital detection of microRNAs using background-free molecular circuit  Science Magazine · 42 minutes
MicroRNAs, a class of transcripts involved in the regulation of gene expression, are emerging as promising disease-specific biomarkers accessible from tissues or bodily fluids. However, their accurate quantification from biological... more
[Research Articles] PI4KIII{beta} is a therapeutic target in chromosome 1q-amplified lung adenocarcinoma  Science Magazine · 43 minutes
Heightened secretion of protumorigenic effector proteins is a feature of malignant cells. Yet, the molecular underpinnings and therapeutic implications of this feature remain unclear.... more
[Research Articles] Pan-viral protection against arboviruses by activating skin macrophages at the inoculation site  Science Magazine · 43 minutes
Arthropod-borne viruses (arboviruses) are important human pathogens for which there are no specific antiviral medicines. The abundance of genetically distinct... more
[Research Articles] The IDH-TAU-EGFR triad defines the neovascular landscape of diffuse gliomas  Science Magazine · 43 minutes
Gliomas that express the mutated isoforms of isocitrate dehydrogenase 1/2 (IDH1/2) have better prognosis than wild-type (wt) IDH1/2 gliomas. However, how these mutant (mut)... more
Scientists identify gene that puts brakes on tissue growth  PHYS.ORG · 48 minutes
The planarian flatworm is a simple animal with a mighty and highly unusual ability: it can regenerate itself from nearly every imaginable injury, including decapitation. These tiny worms can regrow... more
First mushrooms appeared earlier than previously thought  PHYS.ORG · 48 minutes
According to a new study led by Steeve Bonneville from the Université libre de Bruxelles, the first mushrooms evolved on Earth between 715 and 810 million years ago, 300 million years earlier than the... more
Domesticated wheat has complex parentage  PHYS.ORG · 48 minutes
Certain types of domesticated wheat have complicated origins, with genetic contributions from wild and cultivated wheat populations on opposite sides of the Fertile Crescent. Terence Brown and colleagues at the University of Manchester report these findings in a... more
Genetic identification of human remains from the Spanish Civil War and the dictatorship  PHYS.ORG · 1 hour
It is estimated that around 114,000 people disappeared throughout Spain during the Spanish Civil War and subsequent dictatorship. Unfortunately, eight decades on,... more
First ancient DNA from West/Central Africa illuminates deep human past  PHYS.ORG · 1 hour
An international team led by Harvard Medical School scientists has produced the first genome-wide ancient human DNA sequences from west and central Africa. more
New survey results reveal the experts and public's attitude towards gene-edited crops  PHYS.ORG · 1 hour
Experts' interest in utilizing gene editing for breeding crops has seen revolutionary growth. Meanwhile, people's awareness of food safety has also been increasing. To... more
New roles found for Huntington's disease protein  SCIENCE DAILY · 1 hour
A research team has identified a new function of a gene called huntingtin, a mutation of which underlies the progressive neurodegenerative disorder known as Huntington's Disease. Using genetic mouse models, they have discovered that... more
Our biological clock plays crucial role in healing from surgery  SCIENCE DAILY · 1 hour
If you have just had knee, shoulder or hip surgery, you may want to take anti-inflammatories in the morning or at noon, but not at night. A new... more
Cognitive function in people with mental illness  SCIENCE DAILY · 1 hour
A study has shown few differences in the profiles of genes that influence cognition between people with schizophrenia, bipolar disorder and the general population. This surprising finding could provide new insights into therapies designed... more
Study sheds light on mechanisms that underlie a rare genetic condition  NEWS MEDICAL · 5 hours
A team of researchers at CHU Sainte-Justine and Université de Montréal has shed light on the mechanisms that underlie a rare genetic condition by creating the... more
Ranging behavior found to impact motor self-regulation in free-range chickens  PHYS.ORG · 6 hours
A team of researchers from Yncréa Hauts-de-France and Université de Tours, has found that the ranging behavior of free-range chickens can impact their motor self-regulation. In their paper... more
A heart-healthy protein from bran of cereal crop  PHYS.ORG · 7 hours
Foxtail millet is an annual grass grown widely as a cereal crop in parts of India, China and Southeast Asia. Milling the grain removes the hard outer layer, or bran, from the... more
Study reveals pre-Hispanic history, genetic changes among indigenous Mexican populations  PHYS.ORG · 12 hours
As more and more large-scale human genome sequencing projects get completed, scientists have been able to trace with increasing confidence both the geographical movements and underlying genetic variation... more
Urine fertilizer: 'Aging' effectively protects against transfer of antibiotic resistance  PHYS.ORG · 12 hours
Recycled and aged human urine can be used as a fertilizer with low risks of transferring antibiotic resistant DNA to the environment, according to new research from the... more
Case Western researchers suggest potential Alzheimer's breakthrough  NEWS MEDICAL · 16 hours
Researchers at the Case Western University School of Medicine say they have identified a previously unknown gene and associated protein which could potentially be suppressed to slow the advance of Alzheimer's disease. more
Study shows how gene therapy may help protect against vision loss in multiple sclerosis  NEWS MEDICAL · 17 hours
New research by Dorothy P. Schafer, PhD, at the University of Massachusetts Medical School, reveals the molecular process in which... more
Researchers show potential link between a genetic variation and atrial fibrillation  NEWS MEDICAL · 17 hours
Researchers from the Faculty of Health and Medical Sciences have shown a possible link between a genetic variation and the widespread type of cardiac arrhythmia, atrial... more
Circadian clock genes are involved in healing from surgery, study shows  NEWS MEDICAL · 17 hours
If you have just had knee, shoulder or hip surgery, you may want to take anti-inflammatories in the morning or at noon, but not at night. more
Research team identifies new roles for Huntington's Disease protein  NEWS MEDICAL · 19 hours
A Duke University research team has identified a new function of a gene called huntingtin, a mutation of which underlies the progressive neurodegenerative disorder known as Huntington's Disease. more
George Mason University researchers receive $314,000 to design better vaccines  NEWS MEDICAL · 19 hours
George Mason University's Aarthi Narayanan, Associate Professor, College of Science and the National Center for Biodefense and Infectious Disease, and Remi Veneziano, Assistant Professor, Volgenau School of Engineering,... more
Cardiac and visual degeneration compensated by taurine supplement  NEWS MEDICAL · 21 hours
Our genome consists of 20,000 genes, all of which may be capable of triggering disease. It is estimated that there are 7,000 unknown genes that cause recessive genetic diseases resulting from mutations... more
Scientists uncover new mode of evolution  LIVE SCIENCE · 22 hours
Scientists have discovered a form of natural selection that doesn't rely on DNA. more
An asteroid wiped out the dinosaurs. Then, a volcano helped life flourish.  LIVE SCIENCE · 23 hours
A massive meteorite impact and extreme volcanic activity occurred around the same time that Earth's large dinosaurs went extinct. But, did the volcanic activity... more
New genetic test to predict and prevent vision loss from glaucoma  NEWS MEDICAL · 24 hours
Researchers have identified 107 genes that increase a person's risk of developing the eye disease glaucoma, and now developed a genetic test to detect those at... more
Zebrafish teach researchers more about atrial fibrillation  SCIENCE DAILY · 24 hours
Genetic research in zebrafish has surprised the researchers behind the study. The results have the potential to change the prevalent perception of the cardiac disorder atrial fibrillation. more
Advancing the application of genomic sequences through 'Kmasker plants'  PHYS.ORG · 1 day
The development of next-generation-sequencing (NGS) has enabled researchers to investigate genomes that might previously have been considered too complex or too expensive. Nevertheless, the analysis of complex plant genomes, which... more
Platypus on brink of extinction  SCIENCE DAILY · 1 day
New research calls for national action to minimize the risk of the platypus vanishing due to habitat destruction, dams and weirs. more
Novel artificial intelligence system reveals genes that drive tumor growth  NEWS MEDICAL · 1 day
A method for finding genes that spur tumor growth takes advantage of machine learning algorithms to sift through reams of molecular data collected from studies of cancer cell... more
Fight for Sight funds research to investigate genetic risk of age-related macular degeneration  NEWS MEDICAL · 2 days
Eye research charity Fight for Sight is funding researchers from the University of Manchester to investigate the genetic risk of the UK’s... more
Designing lasers based on quantum physics  PHYS.ORG · 2 days
A five-country research team coordinated by Germán J. de Valcárcel Gonzalvo, Professor of Optics at the University of Valencia, has developed a new theory —the coherent master equation— that describes the behavior of pulsed lasers based... more
It was microbial mayhem in the Chicxulub crater, research suggests  PHYS.ORG · 2 days
New insights into how microbial life was quickly re-established following the mass extinction of the dinosaurs have been detailed for the first time by Curtin University-led research. more
Modern face of Homo antecessor may have had insufficient room for wisdom teeth  PHYS.ORG · 2 days
A study led by the University of Bordeaux and the Dental Anthropology Group of the Centro Nacional de Investigación sobre la Evolución... more
Australia fires 'devastating habitats' of endangered species  PHYS.ORG · 2 days
Australia's bushfires and other climate change effects are devastating the habitats of critically endangered species and driving the native platypus towards extinction, according to surveys highlighting the country's vulnerability to rising temperatures. more
Climate change pushing Australia's platypus towards extinction: researchers  PHYS.ORG · 2 days
Prolonged drought and other effects of climate change are pushing Australia's unique platypus population towards extinction, scientists warned in a study published Monday. more
Clones help famous elm tree named Herbie live on, for now  PHYS.ORG · 3 days
A massive elm tree nicknamed Herbie is long gone, but it is going to live on, thanks to cloned trees that are being made available to... more
Microbiome DNA signature present in human fetal lungs  NEWS MEDICAL · 5 days
The lungs and placentas of fetuses in the womb -- as young as 11 weeks after conception -- already show a bacterial microbiome signature, which suggests that bacteria may colonize the lungs... more
UCR receives $2.2 million grant to target critical oncogenes of B-cell lymphoma 2  NEWS MEDICAL · 5 days
One way to tackle cancer, the second-leading cause of death in the United States, is to target oncogenes -- genes that have... more
Airway brush cells generate cysteinyl leukotrienes through the ATP sensor P2Y2  Science Magazine · 5 days
Chemosensory epithelial cells (EpCs) are specialized cells that promote innate type 2 immunity and protective neurally mediated reflexes in the airway. Their effector programs and modes... more
Shape-morphing living composites  Science Magazine · 5 days
This work establishes a means to exploit genetic networks to create living synthetic composites that change shape in response to specific biochemical or physical stimuli. Baker’s yeast embedded in a hydrogel forms a responsive material where cellular proliferation leads to... more
Low doses of radiation used in medical imaging lead to mutations in cell cultures  SCIENCE DAILY · 5 days
Common medical imaging procedures use low doses of radiation that are believed to be safe. A new study, however, finds... more
Medical News Today: What factors influence a person's height?  MNT · 5 days
Genes determine around 80% of a person's height, but environmental factors can also affect it. This article looks at how people can increase their height during development. more
Activation of a distinct genetic pathway can slow the progress of metastatic breast cancer  SCIENCE DAILY · 5 days
Activation of the BMP4 signalling pathway presents a new therapeutic strategy to combat metastatic breast cancer, a disease that has... more
Programmable nests for cells  nanowerk · 5 days
Researchers developed novel composites of DNA, silica particles, and carbon nanotubes - properties can be tailored to various applications. more
Programmable nests for cells  PHYS.ORG · 5 days
Using DNA, small silica particles, and carbon nanotubes, researchers of Karlsruhe Institute of Technology (KIT) have developed novel programmable nanocomposites that can be tailored to various applications and programmed to degrade quickly and gently. For medical applications, they can create... more
An evolving understanding of extinction  PHYS.ORG · 5 days
Few things related to science capture the imagination more than the magic of worlds past. This includes the origins of life, dinosaurs, mass extinctions, meteorite impacts, and the evolution of our species. Understanding the evolution of life is... more
Black rhino population shows steady growth  PHYS.ORG · 5 days
Good news stories can be hard to come by in an era of extinction, but the steady improvement in the fortunes of the black rhino is one of those stories. more
America's most widely consumed oil causes genetic changes in the brain  SCIENCE DAILY · 5 days
New research shows soybean oil not only leads to obesity and diabetes, but could also affect neurological conditions like autism, Alzheimer's disease, anxiety, and depression. more
First randomized clinical trial compares targeted therapies for acute lymphoblastic leukemia  NEWS MEDICAL · 5 days
Researchers from St. Jude Children's Research Hospital and the Chinese Children's Cancer Group led the first randomized, Phase III clinical trial comparing targeted therapies for acute... more
Genetically engineered mosquitoes halt Dengue spread  NEWS MEDICAL · 6 days
A new study published in the journal PLOS Pathogens in January 2020 reports the development of mosquitoes that have been genetically modified to resist infection by several types of the dengue virus. This is the first... more
"Jumping genes" within eggs determine their survival  NEWS MEDICAL · 6 days
Females are born with a finite supply of eggs and with age the genetic quality of the eggs decline say researchers from Carnegie Institute. The study from researchers Marla Tharp, Safia Malki, and Alex... more
Hormone resistance in breast cancer linked to DNA 'rewiring'  SCIENCE DAILY · 6 days
Researchers have revealed changes to the 3D arrangement of DNA linked to treatment resistance in ER+ breast cancer. more
Research shows how the body tries to eliminate egg cells of poorest quality  NEWS MEDICAL · 6 days
A woman's supply of eggs is finite, so it is crucial that the quality of their genetic material is ensured. New work... more
3D structure of DNA is 'rewired' in hormone-resistant ER+ breast cancers  NEWS MEDICAL · 6 days
Epigenetic changes occur in the DNA of breast cancer cells that have developed a resistance to hormone therapy, an effective treatment for ER+ breast cancer, which... more
In death of dinosaurs, it was all about the asteroid -- not volcanoes  SCIENCE DAILY · 6 days
Volcanic activity did not play a direct role in the mass extinction event that killed the dinosaurs, according to an international team... more
N6-methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription  Science Magazine · 6 days
N6-methyladenosine (m6A) regulates stability and translation of messenger RNA (mRNA) in various biological processes. Here, we showed that knockout of the m6A writer Mettl3 or a nuclear reader... more
Microscopy technique reveals cells' 3-D ultrastructure in new detail  PHYS.ORG · 6 days
Inside a cell, tentacled vesicles shuttle cargo for sorting. DNA rearranges in the nucleus as stem cells differentiate into neurons. Neighboring neurons cling to one another through a web-like interface.... more
In death of dinosaurs, it was all about the asteroid—not volcanoes  PHYS.ORG · 6 days
Volcanic activity did not play a direct role in the mass extinction event that killed the dinosaurs, according to an international, Yale-led team of researchers. It... more
On impact and volcanism across the Cretaceous-Paleogene boundary  Science Magazine · 6 days
The cause of the end-Cretaceous mass extinction is vigorously debated, owing to the occurrence of a very large bolide impact and flood basalt volcanism near the boundary. Disentangling their relative importance is... more
A high-resolution summary of Cambrian to Early Triassic marine invertebrate biodiversity  Science Magazine · 6 days
One great challenge in understanding the history of life is resolving the influence of environmental change on biodiversity. Simulated annealing and genetic algorithms were used to... more
Medical News Today: Schizophrenia: Largest genetic study offers new insights  MNT · 6 days
The largest study of its kind analyzed genetic information from 3,444 families and found one single gene whose mutations may help explain the condition. more
Medical News Today: Aicardi syndrome: Everything you need to know  MNT · 6 days
Aicardi syndrome is a rare genetic condition that causes seizures, vision problems, and other symptoms. Here, learn about treatments and more. more
'Living fossil' may upend basic tenet of evolutionary theory  SCIENCE DAILY · 6 days
A research team has discovered the first conclusive evidence that selection may also occur at the level of the epigenome -- a term that refers to an assortment of chemical... more
Cancer study may accidentally help researchers create usable blood stem cells  SCIENCE DAILY · 6 days
A new study shows that cancer-causing MLL gene may also push pluripotent stem cells to make hematopoietic stem cells, a strong step in the decades-long effort... more
Study unravels new insights into a Parkinson's disease protein  SCIENCE DAILY · 6 days
The new study explores alpha-synuclein's basic properties, with a focus on a section of the protein known as the non-amyloidal component (NAC). The research was done on fruit fly larvae... more
Scientists uncover how an explosion of new genes explain the origin of land plants  SCIENCE DAILY · 6 days
Scientists have made a significant discovery about the genetic origins of how plants evolved from living in water to land... more
An electrically pumped surface-emitting semiconductor green laser  PHYS.ORG · 6 days
Scientists and Engineers have used surface-emitting semiconductor lasers in data communications, for sensing, in FaceID and within augmented reality glasses. In a new report, Yong-Ho Ra and a research team in the departments of... more
Factors that ensure cellular protein production  PHYS.ORG · 6 days
Defects in tRNA biogenesis influence gene expression and are associated with many types of human diseases, such as cancer and neurological diseases. In his thesis, Fu Xu contributes to new knowledge about the factors that modulate... more
Scientists uncover how an explosion of new genes explain the origin of land plants  PHYS.ORG · 6 days
The new study, led by scientists from the universities of Bristol and Essex and published today in Current Biology, challenge... more
Harmful genetic mutations in healthy donors' stem cells may create problems in AML patients  NEWS MEDICAL · 6 days
A stem cell transplant - also called a bone marrow transplant - is a common treatment for blood cancers, such... more
Exploring tiny forces with single molecule force spectroscopy  PHYS.ORG · 6 days
In terms of space organization, DNA has powers rivaling Marie Kondo. A strand of DNA that is two meters long intricately folds itself into a cell nucleus only 10 microns across. (One... more
Bird species are facing extinction hundreds of times faster than previously thought  PHYS.ORG · 6 days
Extinction, or the disappearance of an entire species, is commonplace. Species have been forming, persisting and then shuffling off their mortal coil since life began on... more
'Methylation clock' gene found to have functional role in aging of the eye  NEWS MEDICAL · 6 days
A lengthy-named gene called Elongation of Very Long Chain Fatty Acids Protein 2 or ELOVL2 is an established biomarker of age. more
OU collaborates with Peruvian University to develop $9 million joint research program  NEWS MEDICAL · 6 days
The University of Oklahoma has entered an agreement to develop a $9 million program of joint research with Universidad Nacional de San Agustin, one... more
Mutations in donors' stem cells may cause problems for cancer patients  SCIENCE DAILY · 6 days
A new study suggests that extremely rare, harmful genetic mutations present in healthy donors' stem cells -- though not causing health problems in the donors --... more
Jumping genes threaten egg cell quality  SCIENCE DAILY · 6 days
A woman's supply of eggs is finite, so it is crucial that the quality of their genetic material is ensured. New work elucidates a mechanism by which, even before birth, the body tries to eliminate egg... more
New mechanisms describe how the genome regulates itself  PHYS.ORG · 6 days
An organism's genome contains all of the information necessary for each of its cells and tissues to develop and function properly. Written in DNA, each individual gene encodes for something, whether it... more
Potential to adapt is revealed by evolutionary genomics  PHYS.ORG · 6 days
Global climate change is going to drastically alter the environmental conditions for humans and nature. Animals and plants unable to cope with the new conditions are thus forced to shift their range... more
OGT launches high-quality NGS panel for research into Chronic Lymphocytic Leukemia  NEWS MEDICAL · 6 days
Oxford Gene Technology, A Sysmex Group Company, is excited to announce the launch of its SureSeq CLL + CNV Panel — the company’s latest high-quality, next-generation... more
Decontaminating pesticide-polluted water using engineered nanomaterial  PHYS.ORG · 6 days
Atrazine is one of the most widely used pesticides in North America. Researchers at the Institut National de la Recherche Scientifique (INRS) have developed a new method to degrade it that combines a new nanostructured material... more
New software to better understand conversations between cells  PHYS.ORG · 6 days
One of the most fascinating and important properties of living cells is their capacity for self-organization. By talking to each other, cells can, among other things, determine where they are in relation... more
Jumping genes threaten egg cell quality  PHYS.ORG · 6 days
A woman's supply of eggs is finite, so it is crucial that the quality of their genetic material is ensured. New work from Carnegie's Marla Tharp, Safia Malki, and Alex Bortvin elucidates a mechanism by which,... more
Researchers identify gene with functional role in aging of eye  SCIENCE DAILY · 1 week
Researchers say a gene known to be a biomarker of age plays a key role in age-associated functional and anatomical aging in mouse retinas, a finding that has... more
Highly efficient and tumor-selective nanoparticles for dual-targeted immunogene therapy against cancer  Science Magazine · 1 week
While immunotherapy holds great promise for combating cancer, the limited efficacy due to an immunosuppressive tumor microenvironment and systemic toxicity hinder the broader application of cancer... more
Functional validity, role, and implications of heavy alcohol consumption genetic loci  Science Magazine · 1 week
High alcohol consumption is a risk factor for morbidity and mortality, yet few genetic loci have been robustly associated with alcohol intake. Here, we use U.K.... more
Antibiotic production in Streptomyces is organized by a division of labor through terminal genomic differentiation  Science Magazine · 1 week
One of the hallmark behaviors of social groups is division of labor, where different group members become specialized... more
Microglia response following acute demyelination is heterogeneous and limits infiltrating macrophage dispersion  Science Magazine · 1 week
Microglia and infiltrating macrophages are thought to orchestrate the central nervous system (CNS) response to injury; however, the similarities between these cells make it... more
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