Patient Outcomes of Prostate Cancer with Whole Slide Imaging
NEWS MEDICAL
An interview with Dr. Anil Parwani, discusses how whole slide imaging of prostate cancer sections is helping to inform pathologists and improve patient outcomes.
An interview with Dr. Anil Parwani, discusses how whole slide imaging of prostate cancer sections is helping to inform pathologists and improve patient outcomes.
3 hours
Medical News Today: Immunotherapy successful against deadly breast cancer
MNT
A new trial confirms that a combination of immunotherapy and chemotherapy boosts survival rates for people with triple-negative breast cancer.
A new trial confirms that a combination of immunotherapy and chemotherapy boosts survival rates for people with triple-negative breast cancer.
4 hours
Judge slashes award but upholds verdict in Monsanto cancer trial
PHYS.ORG
A San Francisco judge on Monday upheld a jury verdict that found Monsanto liable for not warning a groundskeeper that its weed killer product Roundup might cause cancer,...
A San Francisco judge on Monday upheld a jury verdict that found Monsanto liable for not warning a groundskeeper that its weed killer product Roundup might cause cancer, but slashed the damages award.
5 hours
Advanced breast cancer patients can benefit from immunotherapy-chemotherapy combination
NEWS MEDICAL
Patients with an aggressive form of advanced breast cancer can benefit from immunotherapy when used in combination with chemotherapy as first-line treatment, according to the results of a large international...
Patients with an aggressive form of advanced breast cancer can benefit from immunotherapy when used in combination with chemotherapy as first-line treatment, according to the results of a large international Phase III clinical trial published today in the New England...
5 hours
Study reveals new treatment option for women with advanced breast cancer resistant to hormone therapy
NEWS MEDICAL
Treatment with the cyclin dependent kinase 4/6 inhibitor palbociclib achieves a clinically meaningful improvement in overall survival in...
Treatment with the cyclin dependent kinase 4/6 inhibitor palbociclib achieves a clinically meaningful improvement in overall survival in patients with hormone receptor positive human epidermal growth factor receptor-2 negative advanced breast cancer that has relapsed or progressed on hormonal therapy,...
5 hours
Drugs approved for breast cancer treatment are effective and well tolerated in men
NEWS MEDICAL
There is growing evidence that drugs approved for the treatment of breast cancer in women are also effective and well tolerated in...
There is growing evidence that drugs approved for the treatment of breast cancer in women are also effective and well tolerated in men, according to the largest real-life study yet to investigate treatment and outcomes in men with breast cancer...
5 hours
Forbius initiates Phase 2a trial evaluating efficacy, safety of AVID100 in patients with squamous NSCLC
NEWS MEDICAL
Forbius, a clinical stage company developing biotherapeutics targeting EGFR and TGF-β pathways, today announced that the first patient...
Forbius, a clinical stage company developing biotherapeutics targeting EGFR and TGF-β pathways, today announced that the first patient has been dosed in a Phase 2a trial evaluating the efficacy and safety of AVID100 in patients with squamous non-small cell lung...
6 hours
Construction is underway for second proton therapy system at Siteman Cancer Center
NEWS MEDICAL
Mevion Medical System announces that construction is underway for a second proton therapy system at Siteman Cancer Center at Barnes-Jewish Hospital and Washington University...
Mevion Medical System announces that construction is underway for a second proton therapy system at Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine in St. Louis. T
6 hours
New discovery may lead to better treatment options for pancreatic cancer patients
NEWS MEDICAL
Pancreatic cancer is one of the most difficult cancers to treat and is a leading cause of cancer-related deaths. Now, Sidney Kimmel Cancer Center...
Pancreatic cancer is one of the most difficult cancers to treat and is a leading cause of cancer-related deaths. Now, Sidney Kimmel Cancer Center - Jefferson Health and Lankenau Institute for Medical Research scientists find that a gene involved in...
7 hours
NCI grant awarded to Abramson Cancer Center to study CAR T cells In solid tumors
NEWS MEDICAL
A new program project grant from the National Cancer Institute will fund research by the Translational Center of...
A new program project grant from the National Cancer Institute will fund research by the Translational Center of Excellence for Lung Cancer Immunology at the Abramson Cancer Center of the University of Pennsylvania to improve the effectiveness of chimeric antigen...
8 hours
Organic food may protect against cancers finds study
NEWS MEDICAL
The study published this week in the latest issue of the journal JAMA Internal Medicine reports that people who consume more organic foods are at a lower overall risk of developing cancer...
The study published this week in the latest issue of the journal JAMA Internal Medicine reports that people who consume more organic foods are at a lower overall risk of developing cancer compared to people who do not. Some of...
8 hours
Cancer treatment may undergo a paradigm shift to immunotherapy soon
NEWS MEDICAL
Immunotherapy when used for cancer treatment could extend life longer finds studies. Experts have explained that until now immunotherapy was reserved as a last resort for most patients...
Immunotherapy when used for cancer treatment could extend life longer finds studies. Experts have explained that until now immunotherapy was reserved as a last resort for most patients and treatment usually comprised of chemotherapy and radiation therapy failing which these...
8 hours
Patient-reported data confirms efficacy of brachytherapy alone in intermediate risk prostate cancer
NEWS MEDICAL
Oncology trial RTOG 0232 comparing a combined treatment of external beam therapy and brachytherapy to transperineal interstitial permanent brachytherapy alone indicate a significantly different...
Oncology trial RTOG 0232 comparing a combined treatment of external beam therapy and brachytherapy to transperineal interstitial permanent brachytherapy alone indicate a significantly different clinician and patient-reported late toxicity profile between arms despite similarities in progression-free survival results.
10 hours
Research offers new hope to men who received childhood cancer treatment
NEWS MEDICAL
Researchers have discovered a way to grow human stem cells destined to become mature sperm in an effort to provide fertility options later in life to...
Researchers have discovered a way to grow human stem cells destined to become mature sperm in an effort to provide fertility options later in life to males who are diagnosed with cancer and undergo chemotherapy and radiation as children.
10 hours
New drug combination destroys chemo-resistant blood cancer
SCIENCE DAILY
Researchers have developed a promising targeted strategy to treat chemotherapy-resistant acute myeloid leukemia (AML) and a diagnostic test to determine which AML patients would most likely benefit from this treatment. In a mouse model,...
Researchers have developed a promising targeted strategy to treat chemotherapy-resistant acute myeloid leukemia (AML) and a diagnostic test to determine which AML patients would most likely benefit from this treatment. In a mouse model, the experimental treatment eliminated all signs...
17 hours
New tool gives deeper understanding of glioblastoma
SCIENCE DAILY
Researchers have developed a new tool to study genetic 'switches' active in glioblastoma tumors that drive growth of the cancer. In a new article, they identified key switches in different types of tumors, including...
Researchers have developed a new tool to study genetic 'switches' active in glioblastoma tumors that drive growth of the cancer. In a new article, they identified key switches in different types of tumors, including switches linked to how long a...
18 hours
Researchers develop promising targeted strategy to treat chemo-resistant blood cancer
NEWS MEDICAL
Researchers from The Ottawa Hospital and the University of Ottawa have developed a promising targeted strategy to treat chemotherapy-resistant acute myeloid leukemia and a diagnostic test to determine...
Researchers from The Ottawa Hospital and the University of Ottawa have developed a promising targeted strategy to treat chemotherapy-resistant acute myeloid leukemia and a diagnostic test to determine which AML patients would most likely benefit from this treatment.
18 hours
Study: Targeting specific genomic mutation in breast cancer improves survival
NEWS MEDICAL
Targeting a common mutation in patients with hormone receptor positive (HR+) HER2 negative (HER2-) advanced breast cancer with the alpha-specific phosphatidylinositol-3-kinase (PI3K) inhibitor alpelisib significantly improves progression-free survival,...
Targeting a common mutation in patients with hormone receptor positive (HR+) HER2 negative (HER2-) advanced breast cancer with the alpha-specific phosphatidylinositol-3-kinase (PI3K) inhibitor alpelisib significantly improves progression-free survival, according to late-breaking results reported at ESMO 2018.
19 hours
Immunotherapy with pembrolizumab extends survival in metastatic or recurrent head and neck cancer
NEWS MEDICAL
Immunotherapy with pembrolizumab improves survival in patients with head and neck cancer that has recurred or metastasized, according to late-breaking results from...
Immunotherapy with pembrolizumab improves survival in patients with head and neck cancer that has recurred or metastasized, according to late-breaking results from the KEYNOTE-048 study reported at the ESMO 2018 Congress in Munich.
19 hours
New protein sequencing method could transform biological research
PHYS.ORG
A team of researchers at The University of Texas at Austin has demonstrated a new way to sequence proteins that is much more sensitive than existing technology, identifying individual protein molecules rather...
A team of researchers at The University of Texas at Austin has demonstrated a new way to sequence proteins that is much more sensitive than existing technology, identifying individual protein molecules rather than requiring millions of molecules at a time....
21 hours
Targeted drug and hormone therapy combination extends breast cancer survival
NEWS MEDICAL
Combining a targeted drug with hormone therapy substantially extends survival for women with advanced breast cancer, a major clinical trial has found.
Combining a targeted drug with hormone therapy substantially extends survival for women with advanced breast cancer, a major clinical trial has found.
22 hours
Understanding architecture of cancer-linked BAF protein complexes provides insight into disease
PHYS.ORG
In 2013, Broad Institute member Cigall Kadoch, then a postdoctoral researcher at Stanford University, discovered that approximately 20 percent of all human cancers involve mutations in...
In 2013, Broad Institute member Cigall Kadoch, then a postdoctoral researcher at Stanford University, discovered that approximately 20 percent of all human cancers involve mutations in a group of proteins called BAF, a complex that is also linked to intellectual...
23 hours
Study describes cellular factories in greater detail
PHYS.ORG
Many important natural products such as antibiotics, immunosuppressants and cancer drugs are derived from microorganisms. These natural products are often small proteins or peptides generated in the cell by NRPS enzymes similar to a...
Many important natural products such as antibiotics, immunosuppressants and cancer drugs are derived from microorganisms. These natural products are often small proteins or peptides generated in the cell by NRPS enzymes similar to a modern automobile factory: At each station,...
1 day
WATCH: Purdue superfan inspires team's unlikely win over Ohio State
ABC NEWS
Tyler Trent, 20, a Purdue sophomore, has terminal bone cancer and was invited by the team to address the players in the locker room.
Tyler Trent, 20, a Purdue sophomore, has terminal bone cancer and was invited by the team to address the players in the locker room.
1 day
Immunotherapy achieves major pathological response in early-stage mismatch repair deficient colon cancer
NEWS MEDICAL
Pre-operative treatment with a combination of the immune checkpoint inhibitors nivolumab and ipilimumab achieves major pathological responses in 100% of early-stage colon cancers with...
Pre-operative treatment with a combination of the immune checkpoint inhibitors nivolumab and ipilimumab achieves major pathological responses in 100% of early-stage colon cancers with mismatch repair deficiencies, according to results reported at ESMO 2018 from the first exploratory phase II...
1 day
Study findings could set new standard of care for advanced anal cancer
NEWS MEDICAL
A new approach to treating advanced anal cancer is safer and more effective than the most widely used current treatment, according to the first...
A new approach to treating advanced anal cancer is safer and more effective than the most widely used current treatment, according to the first ever randomized clinical trial in this group of patients.
1 day
FOTIVDA expected to be included in new ESMO guidelines for advanced renal cell carcinoma
NEWS MEDICAL
EUSA Pharma welcomes the news that FOTIVDA (tivozanib) is expected to be included in the upcoming European Society of Medical...
EUSA Pharma welcomes the news that FOTIVDA (tivozanib) is expected to be included in the upcoming European Society of Medical Oncology clinical practice guidelines for advanced renal cell carcinoma, anticipated to be published at the end of this year.
1 day
Immunotherapy may improve survival in patients with metastatic colorectal cancers
NEWS MEDICAL
Immunotherapy with nivolumab and low-dose ipilimumab could become a new first line treatment in patients with some metastatic colorectal cancers following late-breaking results from the CheckMate-142 trial reported...
Immunotherapy with nivolumab and low-dose ipilimumab could become a new first line treatment in patients with some metastatic colorectal cancers following late-breaking results from the CheckMate-142 trial reported at the ESMO 2018 Congress in Munich.
1 day
Genentech’s combination therapy improves outcome in patients with non-squamous non-small cell lung cancer
NEWS MEDICAL
Genentech, a member of the Roche Group, today announced positive results from the Phase III IMpower130 study of Tecentriq (atezolizumab) plus chemotherapy...
Genentech, a member of the Roche Group, today announced positive results from the Phase III IMpower130 study of Tecentriq (atezolizumab) plus chemotherapy (carboplatin and Abraxane® [albumin-bound paclitaxel; nab-paclitaxel]) for the initial (first-line) treatment of people with previously untreated metastatic non-squamous...
1 day
Combination of Opdivo and Yervoy shows four-year survival benefits in patients with advanced melanoma
NEWS MEDICAL
Bristol-Myers Squibb Company today announced four-year data from the Phase 3 CheckMate -067 clinical trial - the longest follow-up to...
Bristol-Myers Squibb Company today announced four-year data from the Phase 3 CheckMate -067 clinical trial - the longest follow-up to date - which continues to demonstrate durable, long-term survival benefits with the first-line combination of Opdivo (nivolumab) and Yervoy (ipilimumab),...
1 day
Phase III LONSURF study shows progression-free survival in patients with refractory metastatic gastric cancer
NEWS MEDICAL
Servier and Taiho Oncology, Inc. (U.S.), a subsidiary of Taiho Pharmaceutical Co., Ltd. (Japan), jointly announced today clinical data from...
Servier and Taiho Oncology, Inc. (U.S.), a subsidiary of Taiho Pharmaceutical Co., Ltd. (Japan), jointly announced today clinical data from the pivotal Phase III TAS-102 Gastric Study (TAGS) evaluating LONSURF® (trifluridine/tipiracil, TAS-102) versus placebo and best supportive care in patients...
1 day
Merck presents MK-1454 Phase 1 data for treatment of advanced solid tumors or lymphomas
NEWS MEDICAL
Merck, known as MSD outside the United States and Canada, today announced the first presentation of preliminary data from a...
Merck, known as MSD outside the United States and Canada, today announced the first presentation of preliminary data from a Phase 1 clinical trial evaluating MK-1454, an investigational STING (stimulator of interferon genes) agonist, as monotherapy and in combination with...
1 day
Maintenance therapy with olaparib improves progression-free survival in advanced ovarian cancer patients
NEWS MEDICAL
Two-year maintenance therapy with olaparib, a PARP (poly ADP ribose polymerase) inhibitor, olaparib, led to a substantial, unprecedented improvement in progression-free survival (PFS) in...
Two-year maintenance therapy with olaparib, a PARP (poly ADP ribose polymerase) inhibitor, olaparib, led to a substantial, unprecedented improvement in progression-free survival (PFS) in newly diagnosed patients with advanced ovarian cancer and a BRCA1 or 2 mutation, results from the...
1 day
Educational initiatives needed to improve knowledge about biosimilars in oncology
NEWS MEDICAL
Biological medicines are responsible for some of the most promising innovations in cancer treatment, including immunotherapy, targeted drugs and vaccines - but they are also expensive.
Biological medicines are responsible for some of the most promising innovations in cancer treatment, including immunotherapy, targeted drugs and vaccines - but they are also expensive.
1 day
Roche lands Tecentriq trial win, still trails Merck in lung cancer
REUTERS
Roche's Tecentriq plus chemotherapy boosted lung cancer patients' survival by nearly five months, study...
Roche's Tecentriq plus chemotherapy boosted lung cancer patients' survival by nearly five months, study data released on Monday showed, underscoring benefits of the Swiss group's immunotherapy but still leaving it trailing a rival's drug.
1 day
Study shows potential of avelumab plus axitinib as new treatment option for patients with advanced RCC
NEWS MEDICAL
A combination of the immune checkpoint blocker, avelumab, plus the tyrosine kinase inhibitor, axitinib, significantly improves...
A combination of the immune checkpoint blocker, avelumab, plus the tyrosine kinase inhibitor, axitinib, significantly improves progression-free survival in previously untreated patients with advanced renal cell carcinoma in a phase 3 study, according to results presented at ESMO 2018 Congress.
1 day
Pfizer announces PALOMA-3 trial results in patients with HR+, HER2- metastatic breast cancer
NEWS MEDICAL
Pfizer Inc. today announced detailed overall survival data from the PALOMA-3 trial, which evaluated IBRANCE (palbociclib) in combination with fulvestrant compared to...
Pfizer Inc. today announced detailed overall survival data from the PALOMA-3 trial, which evaluated IBRANCE (palbociclib) in combination with fulvestrant compared to placebo plus fulvestrant in women with hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) metastatic breast...
1 day
Merck presents KEYNOTE-057 trial results for patients with high-risk non-muscle invasive bladder cancer
NEWS MEDICAL
Merck, known as MSD outside the United States and Canada, today announced the first presentation of results from an interim analysis of...
Merck, known as MSD outside the United States and Canada, today announced the first presentation of results from an interim analysis of KEYNOTE-057, a Phase 2 trial evaluating KEYTRUDA, Merck's anti-PD-1 therapy, for previously treated patients with high-risk non-muscle invasive...
1 day
HIV-infected Hispanics at higher risk of developing HPV-related cancers, finds study
NEWS MEDICAL
A new study reveals that Hispanic HIV-infected adults in the United States are at a higher risk of developing cancers caused by the human papillomavirus than...
A new study reveals that Hispanic HIV-infected adults in the United States are at a higher risk of developing cancers caused by the human papillomavirus than Hispanics from the general population.
1 day
Prostate radiotherapy improves survival in men with low burden of metastatic disease
NEWS MEDICAL
Radiotherapy to the prostate improves overall survival in men newly diagnosed with metastatic prostate cancer who have a low metastatic disease burden but not...
Radiotherapy to the prostate improves overall survival in men newly diagnosed with metastatic prostate cancer who have a low metastatic disease burden but not in those with higher burden of disease, according to results from a pre-planned analysis of a...
1 day
Study: Erlotinib improves progression-free survival in EGFR mutated NSCLC
NEWS MEDICAL
Neoadjuvant erlotinib benefits selected epidermal growth factor receptor (EGFR)-mutated patients who undergo complete resection of stage IIIA-N2 stage non-small cell lung cancer(NSCLC), shows a randomized study comparing erlotinib with gemcitabine...
Neoadjuvant erlotinib benefits selected epidermal growth factor receptor (EGFR)-mutated patients who undergo complete resection of stage IIIA-N2 stage non-small cell lung cancer(NSCLC), shows a randomized study comparing erlotinib with gemcitabine plus cisplatin as neoadjuvant treatment, presented at the ESMO 2018...
1 day
Immunotherapy increases survival in some patients with metastatic triple negative breast cancer
NEWS MEDICAL
Immunotherapy improves survival in some patients with metastatic triple negative breast cancer, according to late-breaking results from the IMpassion130 trial reported at the ESMO...
Immunotherapy improves survival in some patients with metastatic triple negative breast cancer, according to late-breaking results from the IMpassion130 trial reported at the ESMO 2018 Congress in Munich.
1 day
Deciphera presents Phase 1 clinical results of DCC-2618 in patients with gastrointestinal stromal tumors
NEWS MEDICAL
Deciphera Pharmaceuticals, Inc., a clinical-stage biopharmaceutical company focused on addressing key mechanisms of tumor drug resistance, announced the presentation today...
Deciphera Pharmaceuticals, Inc., a clinical-stage biopharmaceutical company focused on addressing key mechanisms of tumor drug resistance, announced the presentation today of updated preliminary results from its ongoing Phase 1 clinical study of DCC-2618, the company's broad-spectrum KIT and PDGFRα inhibitor,...
1 day
Zoledronic acid increases disease-free survival in premenopausal women with HR+ early breast cancer
NEWS MEDICAL
Adjuvant treatment with the bone sparing drug zoledronic acid plus hormonal therapy with the aromatase inhibitor letrozole significantly increases disease-free survival compared...
Adjuvant treatment with the bone sparing drug zoledronic acid plus hormonal therapy with the aromatase inhibitor letrozole significantly increases disease-free survival compared to tamoxifen in premenopausal women with hormone receptor positive (HR+) early breast cancer, according to results reported at...
1 day
Multi-strain probiotic helps reduce chemotherapy-induced diarrhea in cancer patients
NEWS MEDICAL
A high concentration of multi-strain probiotic helps to reduce mild to moderate episodes of chemotherapy-induced diarrhea in cancer patients, according to results of a phase II/III study in India.
A high concentration of multi-strain probiotic helps to reduce mild to moderate episodes of chemotherapy-induced diarrhea in cancer patients, according to results of a phase II/III study in India.
1 day
Immunotherapy trial offers new hope for people with aggressive breast cancer
NEWS MEDICAL
There is new hope for people with an aggressive type of breast cancer, as an immunotherapy trial shows for the first time that lives can be...
There is new hope for people with an aggressive type of breast cancer, as an immunotherapy trial shows for the first time that lives can be extended in people with triple-negative breast cancer.
1 day
Incyte announces Phase 2 FIGHT-202 trial data in patients with cholangiocarcinoma
NEWS MEDICAL
Incyte Corporation announces updated data from its ongoing Phase 2 FIGHT-202 trial evaluating pemigatinib (INCB54828), its selective fibroblast growth factor receptor (FGFR) inhibitor, in patients with...
Incyte Corporation announces updated data from its ongoing Phase 2 FIGHT-202 trial evaluating pemigatinib (INCB54828), its selective fibroblast growth factor receptor (FGFR) inhibitor, in patients with advanced/metastatic or surgically unresectable cholangiocarcinoma (bile duct cancer) who failed at least one previous...
1 day
Exelixis presents CABOSUN and METEOR trial results in patients with advanced renal cell carcinoma
NEWS MEDICAL
Exelixis, Inc. today announced results from two analyses evaluating the effect of PD-L1 expression or prior treatment with immune checkpoint...
Exelixis, Inc. today announced results from two analyses evaluating the effect of PD-L1 expression or prior treatment with immune checkpoint inhibitors on the efficacy of cabozantinib in patients with advanced renal cell carcinoma (RCC). The findings are being presented this...
1 day
Takeda announces positive Phase 3 ALTA-1L data in first-line therapy for advanced ALK+ NSCLC
NEWS MEDICAL
Takeda Pharmaceutical Company Limited today announced that intracranial efficacy data from the Phase 3 ALTA-1L (ALK in Lung Cancer Trial...
Takeda Pharmaceutical Company Limited today announced that intracranial efficacy data from the Phase 3 ALTA-1L (ALK in Lung Cancer Trial of BrigAtinib in 1st Line) trial showed improved intracranial progression-free survival (PFS) and intracranial objective response rate (ORR) with ALUNBRIG...
1 day
ImmunoGen announces study results of platinum-resistant ovarian cancer therapy at ESMO 2018 Congress
NEWS MEDICAL
ImmunoGen, Inc., a leader in the expanding field of antibody-drug conjugates for the treatment of cancer, today announced initial safety and preliminary...
ImmunoGen, Inc., a leader in the expanding field of antibody-drug conjugates for the treatment of cancer, today announced initial safety and preliminary anti-tumor activity from the FORWARD II expansion cohort assessing mirvetuximab soravtansine in combination with Merck's anti-PD-1 therapy, KEYTRUDA...
1 day
Shorter course of trastuzumab could be an option for women with HER2+ early breast cancer
NEWS MEDICAL
Women with HER2-positive early breast cancer with small tumours have similar disease-free survival and lower risk of cardiac...
Women with HER2-positive early breast cancer with small tumours have similar disease-free survival and lower risk of cardiac toxicity with a nine-week course of adjuvant trastuzumab compared to those treated for one year, according to a subgroup analysis of the...
1 day
Breast cancer survival could be extended with two new drug combinations
NEWS MEDICAL
A new study has shown that a combination of drugs palbociclib, along with hormone therapy can significantly increase the survival among women with advanced breast cancer.
A new study has shown that a combination of drugs palbociclib, along with hormone therapy can significantly increase the survival among women with advanced breast cancer.
1 day
Radiotherapy can prolong survival in prostate cancer
NEWS MEDICAL
A new major study from London has shown that radiotherapy can extend survival among patients with prostate cancer. The study shows that larger number of patients given standard therapy along with radiation therapy survived...
A new major study from London has shown that radiotherapy can extend survival among patients with prostate cancer. The study shows that larger number of patients given standard therapy along with radiation therapy survived three years after the initiation of...
1 day
AstraZeneca's Lynparza shown to put brakes on ovarian cancer
REUTERS
An AstraZeneca drug that blocks a cancer cell's ability to repair its genetic code greatly reduced the risk...
An AstraZeneca drug that blocks a cancer cell's ability to repair its genetic code greatly reduced the risk of ovarian cancer worsening in a phase III trial, underpinning its lead against two U.S. rivals in the same class.
2 days
Medical News Today: Cancer: Even healthy tissue is 'riddled with mutations'
MNT
A new study charts the slow build-up of genetic mutations. The researchers are surprised to find that even healthy human tissue carries many mutants.
A new study charts the slow build-up of genetic mutations. The researchers are surprised to find that even healthy human tissue carries many mutants.
2 days
Roche takes on Loxo, Bayer in gene-defined cancer class
REUTERS
Roche's entrectinib cancer pill was shown to shrink tumors in 57 percent of patients within a group that...
Roche's entrectinib cancer pill was shown to shrink tumors in 57 percent of patients within a group that can only be identified via genetic profiling, as the Swiss drugmaker challenges an alliance of Bayer and Loxo Oncology in a new...
2 days
High diet quality associated with lower risk of death in colorectal cancer patients
NEWS MEDICAL
Colorectal cancer patients who followed healthy diets had a lower risk of death from colorectal cancer and all causes, even those who...
Colorectal cancer patients who followed healthy diets had a lower risk of death from colorectal cancer and all causes, even those who improved their diets after being diagnosed, according to a new American Cancer Society study.
2 days
Study reveals connection between two proteins known to be hyperactive in cancer
NEWS MEDICAL
A team of researchers at Baylor College of Medicine and Texas Children's Hospital has revealed a connection between mTORC1 and Src, two proteins known...
A team of researchers at Baylor College of Medicine and Texas Children's Hospital has revealed a connection between mTORC1 and Src, two proteins known to be hyperactive in cancer.
2 days
Securing access to optimal cancer care through innovation, integration and sustainability
SCIENCE DAILY
Securing access to optimal cancer care for all patients can only be achieved through integrated, sustainable translation of today's scientific advances into tomorrow's treatments, reinforced by...
Securing access to optimal cancer care for all patients can only be achieved through integrated, sustainable translation of today's scientific advances into tomorrow's treatments, reinforced by a clear understanding of the magnitude of clinical effects and accurate identification of patients...
3 days
Why some cancers affect only young women
SCIENCE DAILY
Among several forms of pancreatic cancer, one of them affects specifically women, often young, even though the pancreas is an organ with little exposure to sex hormones. This pancreatic cancer, known as 'mucinous cyst,'...
Among several forms of pancreatic cancer, one of them affects specifically women, often young, even though the pancreas is an organ with little exposure to sex hormones. This pancreatic cancer, known as 'mucinous cyst,' has strange similarities with another mucinous...
3 days
Immunotherapy scores a first win against some breast cancers
ABC NEWS
A newer immunotherapy drug for the first time has shown promise against breast cancer in a large study that combined it with chemotherapy to treat an aggressive form of the...
A newer immunotherapy drug for the first time has shown promise against breast cancer in a large study that combined it with chemotherapy to treat an aggressive form of the disease
3 days
Roche scores win in slowing aggressive type of breast cancer
REUTERS
An immunotherapy cocktail from Roche helped slow an aggressive type of breast cancer where new treatments...
An immunotherapy cocktail from Roche helped slow an aggressive type of breast cancer where new treatments have proven elusive, offering positive news for the Swiss drugmaker as it chases medicines produced by its rivals.
3 days
Roche's Tecentriq boosts survival in triple-negative breast cancer
REUTERS
An immunotherapy cocktail from Roche helped slow a type of breast cancer where new treatments have proven elusive, data released...
An immunotherapy cocktail from Roche helped slow a type of breast cancer where new treatments have proven elusive, data released on Saturday showed, offering positive news for the Swiss drugmaker as it chases medicines produced by its rivals.
3 days
Novartis drug cut death risk by 35 percent in gene mutation breast cancer
REUTERS
An experimental cancer drug that Novartis hopes will raise the...
An experimental cancer drug that Novartis hopes will raise the profile of its oncology portfolio cut the risk of death or disease progression by more than a third in breast cancer patients with a hard-to-target gene mutation.
3 days
Medical News Today: Using light to destroy metastatic breast cancer
MNT
Metastatic breast cancer may soon be treated using light to activate photo-sensitive drugs which, in turn, can target cancer cells and avoid healthy ones.
Metastatic breast cancer may soon be treated using light to activate photo-sensitive drugs which, in turn, can target cancer cells and avoid healthy ones.
3 days
Distinguishing fatal prostate cancer from 'manageable' cancer now possible
SCIENCE DAILY
Scientists have found a way of distinguishing between fatal prostate cancer and manageable cancer, which could reduce unnecessary surgeries and radiotherapy.
Scientists have found a way of distinguishing between fatal prostate cancer and manageable cancer, which could reduce unnecessary surgeries and radiotherapy.
4 days
Study points to new method to deliver drugs to the brain
SCIENCE DAILY
Researchers have discovered a potentially new approach to deliver therapeutics more effectively to the brain. The research could have implications for the treatment of a wide...
Researchers have discovered a potentially new approach to deliver therapeutics more effectively to the brain. The research could have implications for the treatment of a wide range of diseases, including Alzheimer's, Parkinson's, ALS, and brain cancer.
4 days
Immunotherapy medicine found to be effective in treating uveitis
NEWS MEDICAL
A team of researchers from the UCH CEU's Biomedical Sciences Institute has tested the efficiency of Bevacizumab, medicine used against cancer and in ophtalmology, to treat uveítis, thus stopping the...
A team of researchers from the UCH CEU's Biomedical Sciences Institute has tested the efficiency of Bevacizumab, medicine used against cancer and in ophtalmology, to treat uveítis, thus stopping the inflammation from spreading.
4 days
Study: Some countries take more time for reimbursement decisions on new cancer drugs
NEWS MEDICAL
Some European countries take more than twice as long as others to reach health technology assessment decisions to reimburse new cancer drugs...
Some European countries take more than twice as long as others to reach health technology assessment decisions to reimburse new cancer drugs following their approval by the European Medicines Agency.
4 days
Src regulates mTOR, a major player in cancer growth
PHYS.ORG
A team of researchers at Baylor College of Medicine and Texas Children's Hospital has revealed a connection between mTORC1 and Src, two proteins known to be hyperactive in cancer. The...
A team of researchers at Baylor College of Medicine and Texas Children's Hospital has revealed a connection between mTORC1 and Src, two proteins known to be hyperactive in cancer. The study, published in the journal Nature Communications, shows that Src...
4 days
Scientists uncover key regulator of mTORC1 in cancer growth
NEWS MEDICAL
Scientists have discovered that Src is needed for activation of mTORC1, a major regulator of cellular metabolism, growth and proliferation in cancer.
Scientists have discovered that Src is needed for activation of mTORC1, a major regulator of cellular metabolism, growth and proliferation in cancer.
4 days
Breast Cancer as a Dynamic Disease
NEWS MEDICAL
VIDEO
An interview with Dr. Andrew Ewald, Ph.D., discussing the influence of the myoepithelium on breast cancer growth and the importance of studying metastasis.
An interview with Dr. Andrew Ewald, Ph.D., discussing the influence of the myoepithelium on breast cancer growth and the importance of studying metastasis.
4 days
Medical News Today: How a 150-year old drug might help battle cancer
MNT
The potency of cancer treatments is often reduced by a lack of oxygen in and around the tumor. Researchers have found an existing drug...
The potency of cancer treatments is often reduced by a lack of oxygen in and around the tumor. Researchers have found an existing drug that might help.
4 days
Newly developed synthetic DNA molecule may one day be used as 'vaccine' for prostate cancer
NEWS MEDICAL
Researchers from City of Hope, a world-renowned comprehensive cancer center and independent biomedical research institution, have developed a...
Researchers from City of Hope, a world-renowned comprehensive cancer center and independent biomedical research institution, have developed a synthetic DNA molecule that is programmed to jump-start the immune system to eradicate genetically distinct types of prostate cancer.
4 days
Case Comprehensive Cancer Center wins NIH grant to study health disparities
NEWS MEDICAL
The Case Comprehensive Cancer Center has received a three-year, $3,194,947 grant from the National Cancer Institute to investigate colorectal and breast cancer health disparities.
The Case Comprehensive Cancer Center has received a three-year, $3,194,947 grant from the National Cancer Institute to investigate colorectal and breast cancer health disparities.
4 days
Study finds link between refined soluble fibers, gut microbiota and liver cancer
NEWS MEDICAL
Many of the processed foods we find on grocery store shelves have been loaded up with highly refined soluble fibers such as inulin, a...
Many of the processed foods we find on grocery store shelves have been loaded up with highly refined soluble fibers such as inulin, a popular probiotic that recently received approval from the Food and Drug Administration to be marketed as...
4 days
High rate of non-adherence to hormonal therapy found among premenopausal early breast cancer patients
NEWS MEDICAL
Nearly one in six premenopausal women being treated for early stage breast cancer do not adhere adequately to tamoxifen therapy...
Nearly one in six premenopausal women being treated for early stage breast cancer do not adhere adequately to tamoxifen therapy after one year of treatment, potentially putting themselves at increased risk of recurrence and reduced survival, a French prospective study...
4 days
Study shows close link between cytokine interleukin-1ß and obesity-promoted colon cancer
NEWS MEDICAL
A new study describes the mechanistic relationship between the cytokine interleukin-1β, (IL-1β) and obesity, showing that when IL-1β levels are increased in obesity, IL-1 receptor signaling...
A new study describes the mechanistic relationship between the cytokine interleukin-1β, (IL-1β) and obesity, showing that when IL-1β levels are increased in obesity, IL-1 receptor signaling activates multiple pathways leading to colon cancer.
4 days
New approach to understanding cancers will accelerate development of better treatments
NEWS MEDICAL
A new innovation in cancer research will enable scientists to understand the complex causes of the disease with unprecedented speed and sophistication. This will accelerate the...
A new innovation in cancer research will enable scientists to understand the complex causes of the disease with unprecedented speed and sophistication. This will accelerate the development of new and better treatments, and it will help researchers find ways around...
4 days
Supracellular contraction at the rear of neural crest cell groups drives collective chemotaxis
Science Magazine
Collective cell chemotaxis, the directed migration of cell groups along gradients of soluble chemical cues, underlies various developmental and pathological processes. We...
Collective cell chemotaxis, the directed migration of cell groups along gradients of soluble chemical cues, underlies various developmental and pathological processes. We use neural crest cells, a migratory embryonic stem cell population whose behavior has been likened to malignant invasion,...
5 days
Somatic mutant clones colonize the human esophagus with age
Science Magazine
The extent to which cells in normal tissues accumulate mutations throughout life is poorly understood. Some mutant cells expand into clones that can be detected by genome sequencing. We mapped...
The extent to which cells in normal tissues accumulate mutations throughout life is poorly understood. Some mutant cells expand into clones that can be detected by genome sequencing. We mapped mutant clones in normal esophageal epithelium from nine donors (age...
5 days
What Caused This Man's Nail to Turn Brown and Striped?
LIVE SCIENCE
Chemotherapy can have odd effects on a person's hair and nails, but in one man's case, the cancer treatment created a particularly striking pattern.
Chemotherapy can have odd effects on a person's hair and nails, but in one man's case, the cancer treatment created a particularly striking pattern.
5 days
Big-picture approach to understanding cancer will speed new treatments
SCIENCE DAILY
The new approach lets scientists examine the cumulative effect of multiple gene mutations, providing a much more complete picture of cancers' causes.
The new approach lets scientists examine the cumulative effect of multiple gene mutations, providing a much more complete picture of cancers' causes.
5 days
[Errata] Erratum for the Research Article: "P-selectin is a nanotherapeutic delivery target in the tumor microenvironment" by Y. Shamay, M. Elkabets, H. Li, J. Shah, S. Brook, F. Wang, K. Adler, E. Baut, M. Scaltriti, P. V. Jena, E. E. Gardner, J. T. Poir
Science Magazine
5 days
Sleeping Beauty technique helps identify genes responsible for NAFLD-associated liver cancer
NEWS MEDICAL
With an estimated twenty-thousand protein-coding genes in the human genome, pinpointing a specific gene or pathway responsible for a particular disease can be like finding a...
With an estimated twenty-thousand protein-coding genes in the human genome, pinpointing a specific gene or pathway responsible for a particular disease can be like finding a needle in the proverbial haystack.
5 days
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