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What Is CRISPR?
LIVE SCIENCE CRISPR technology is a simple yet powerful tool for editing genomes. It allows researchers to easily alter DNA sequences and modify gene function. 6 hours
Study examines how higher-order gene combinations help maintain normal cell physiology
NEWS MEDICAL We inherit many traits from our parents including the color of our eyes and hair. Unfortunately, we also inherit risk factors for certain diseases such as... 7 hours
Scientists identify gene responsible for evolution of recombination rates
NEWS MEDICAL Genetics is a crapshoot. During sexual reproduction, genes from both the mother and the father mix and mingle to produce a genetic combination unique to each offspring. In most cases,... 8 hours
340 000 stars interrogated in search for sun s siblings 340,000 Stars Interrogated in Search for Sun's Siblings
ASTRO WATCH An Australian-led group of astronomers working with European collaborators has revealed the “DNA” of more than 340,000 stars in the... 11 hours
A complete cell atlas and lineage tree of the immortal flatworm
SCIENCE DAILY From one stem cell to many differentiated body cells: Scientists have now published a comprehensive lineage tree of a whole adult animal. This was made possible... 12 hours
Cicadas on different schedules can hybridize
SCIENCE-NEWS A new genetic study suggests that cicadas that emerge every 17 years have swapped genetic material with those that emerge every 13 years. 13 hours
The good, the bad and their fortuitous differences
PHYS.ORG Genetic differences between two very similar fungi, one that led to Quorn, the proprietary meat substitute, and another that ranks among the world's most damaging crop pathogens, have exposed the significant features... 15 hours
New DNA screening reveals whose blood the vampire bat is drinking
SCIENCE DAILY The vampire bat prefers to feed on domestic animals such as cows and pigs. When it does so, there is a risk of transmission of pathogens.... 16 hours
Remote-control shoots laser at nano-gold to turn on cancer-killing immune cells
SCIENCE DAILY Cancer immune cell therapy has made headlines with astounding successes like saving former US President Jimmy Carter from brain cancer. But immunotherapy has also had many... 17 hours
Wood formation model to fuel progress in bioenergy, paper, new applications
PHYS.ORG A new systems biology model that mimics the process of wood formation allows scientists to predict the effects of switching on and off 21 pathway genes... 17 hours
Role of UBE3A enzyme in Angelman syndrome
NEWS MEDICAL The group, led by the Ikerbasque professor Ugo Mayor of the UPV/EHU's Department of Biochemistry and Molecular Biology, has just published in the journal Human Molecular Genetics an explanation of the mechanisms affected by... 19 hours
Evolutionary history of tumor helps predict severity of prostate cancer
NEWS MEDICAL Findings from Canadian Prostate Cancer Genome Network (CPC-GENE) researchers and their collaborators, published today in Cell, show that the aggressiveness of an individual prostate cancer can be accurately... 19 hours
High-tech microscope reveals how cancer-causing virus anchors itself to human DNA
NEWS MEDICAL Using a homemade, high-tech microscope, scientists at the University of Virginia School of Medicine have revealed how a cancer-causing virus anchors itself to our DNA. That... 19 hours
Study reveals surprising insights into RNA-binding proteins
NEWS MEDICAL A host of special molecules called nuclear RNA-binding proteins (RBPs), when misplaced outside the nucleus, form the harmful clumps seen in several brain disorders, including frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). 19 hours
New CRISPR tool allows DNA editing outside of the cell
NEWS MEDICAL Researchers have developed a cell free method of gene editing, which uses a new version of the CRISPR tool that can edit DNA outside of the cell. This... 20 hours
Single-cell database to propel biological studies
PHYS.ORG A team at Whitehead Institute and MIT has harnessed single-cell technologies to analyze over 65,000 cells from the regenerative planarian flatworm, Schmidtea mediterranea, revealing the complete suite of actives genes (or "transcriptome") for practically every type... 22 hours
Scientists discover gene controlling genetic recombination rates
PHYS.ORG Genetics is a crapshoot. During sexual reproduction, genes from both the mother and the father mix and mingle to produce a genetic combination unique to each offspring. In most cases, the chromosomes line up... 22 hours
Researchers build DNA replication in a model synthetic cell
PHYS.ORG Researchers at Delft University of Technology, in collaboration with colleagues at the Autonomous University of Madrid, have created an artificial DNA blueprint for the replication of DNA in a cell-like... 22 hours
New initiative launched to support goals of Human Cell Atlas
NEWS MEDICAL Uri Laserson, PhD, Assistant Professor in the Department of Genetics and Genomics Sciences at the Icahn School of Medicine at Mount Sinai, and collaborators have been awarded one... 1 day
Scientists publish comprehensive lineage tree of whole adult animal in Science journal
NEWS MEDICAL From one stem cell to many differentiated body cells: Scientists from the MDC in Berlin, along with collaborating researchers in Munich, have published a... 1 day
Rare variants in non-coding DNA inherited from parents heighten autism risk
NEWS MEDICAL In recent years, researchers have firmly established that gene mutations appearing for the first time, called de novo mutations, contribute to approximately one-third of cases of... 1 day
HIV-1 viruses transmitted at birth are resistant to antibodies in mother's blood
SCIENCE DAILY Of the genetically diverse population of HIV-1 viruses present in an infected pregnant woman, the few she might transmit to her child during delivery... 1 day
3-D human 'mini-brains' shed new light on genetic underpinnings of major mental illness
SCIENCE DAILY Researchers are leveraging gene-editing tools and mini-organs grown in the lab to study the effects of DISC1 mutations in cerebral organoids --... 1 day
Gene-edited stem cells show promise against HIV in non-human primates
SCIENCE DAILY Gene editing of bone marrow stem cells in pigtail macaques infected with simian/human immunodeficiency virus (SHIV) significantly reduces the size of dormant 'viral reservoirs' that pose a risk... 1 day
Great Barrier Reef coral predicted to last at least 100 years before extinction from climate change
SCIENCE DAILY A common Great Barrier Reef coral species has enough genetic diversity to survive at least 100... 1 day
Unprecedented wave of large-mammal extinctions linked to prehistoric humans
SCIENCE DAILY Homo sapiens, Neanderthals and other recent human relatives may have begun hunting large mammal species down to size -- by way of extinction -- at least 90,000 years earlier than... 1 day
Museum researchers rediscover animal not seen in 30 years
SCIENCE DAILY Researchers have rediscovered the San Quintin kangaroo rat (Dipodomys gravipes) in Baja California. The Museum is partnering with Terra and local authorities on a conservation plan for the species, which... 1 day
Variants in non-coding DNA contribute to inherited autism risk
SCIENCE DAILY In recent years, researchers have firmly established that gene mutations appearing for the first time, called de novo mutations, contribute to approximately one-third of cases of autism spectrum disorder. In... 1 day
Study predicts 2018 flu vaccine will likely have 20 percent efficacy
SCIENCE DAILY A new study of 6,610 human flu sequences predicts that this fall's flu vaccine will likely have the same reduced efficacy against the dominant circulating strain... 2 days
Dogs could be more similar to humans than we thought
SCIENCE DAILY Dog and human gut microbiomes have more similar genes and responses to diet than we previously thought, according to a new study 2 days
Gene variant increases empathy-driven fear in mice
SCIENCE DAILY A small difference in a gene affecting brain circuitry explains variations in empathic fear among different inbred mice strains. As empathy is evolutionarily conserved from rodents to humans, the study brings new insights into... 2 days
Larger spleens may help ‘sea nomads’ stay underwater longer
SCIENCE-NEWS The Bajau people of Southeast Asia have a gene variant associated with larger spleens, boosting their oxygen while breath-hold diving, researchers say. 2 days
U.S. agencies clash over who should regulate genetically engineered livestock
Science Magazine Agriculture department and Food and Drug Administration disagree 2 days
Autistic children may inherit DNA mutations from their fathers
Science Magazine Whole-genome sequencing finds changes in regulatory regions associated with autism 2 days
Paternally inherited cis-regulatory structural variants are associated with autism
Science Magazine The genetic basis of autism spectrum disorder (ASD) is known to consist of contributions from de novo mutations in variant-intolerant genes. We hypothesize that rare inherited structural variants in cis-regulatory... 2 days
Even more genes control cell growth
Science Magazine 2 days
Ancient DNA untangles South Asian roots
Science Magazine 2 days
MFN2 agonists reverse mitochondrial defects in preclinical models of Charcot-Marie-Tooth disease type 2A
Science Magazine Mitofusins (MFNs) promote fusion-mediated mitochondrial content exchange and subcellular trafficking. Mutations in Mfn2 cause neurodegenerative Charcot-Marie-Tooth disease type 2A (CMT2A). We showed... 2 days
Systematic analysis of complex genetic interactions
Science Magazine To systematically explore complex genetic interactions, we constructed ~200,000 yeast triple mutants and scored negative trigenic interactions. We selected double-mutant query genes across a broad spectrum of biological processes, spanning a range of quantitative features of... 2 days
Body size downgrading of mammals over the late Quaternary
Science Magazine Since the late Pleistocene, large-bodied mammals have been extirpated from much of Earth. Although all habitable continents once harbored giant mammals, the few remaining species are largely confined to Africa.... 2 days
Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq
Science Magazine Gliomas with histone H3 lysine27-to-methionine mutations (H3K27M-glioma) arise primarily in the midline of the central nervous system of young children, suggesting a cooperation between genetics and... 2 days
Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms
Science Magazine True physiological imaging of subcellular dynamics requires studying cells within their parent organisms, where all the environmental cues that drive gene expression,... 2 days
A complete cell atlas and lineage tree of the immortal flatworm
PHYS.ORG From one stem cell to many differentiated body cells: Scientists from the MDC in Berlin, along with collaborating researchers in Munich, have published a comprehensive lineage... 2 days
Unprecedented wave of large-mammal extinctions linked to ancient humans
PHYS.ORG Homo sapiens, Neanderthals and other recent human relatives may have begun hunting large mammal species down to size - by way of extinction - at least 90,000 years earlier than... 2 days
Genome Jenga study reveals unexpected gene alliances in the cell
PHYS.ORG To understand how a cell works, biologists like to take it apart. By removing genes from cells in diverse combinations, researchers have now uncovered how different genes work... 2 days
Great Barrier Reef corals can survive global warming for another century
PHYS.ORG Using genetic samples and computer simulations, evolutionary biologists have made a glass-half-full forecast: Corals in the Great Barrier Reef have enough genetic variation to adapt to... 2 days
Neurons derived from super-obese people respond differently to appetite hormones
SCIENCE DAILY Scientists have successfully generated hypothalamic-like neurons from human induced pluripotent stem cells (hiPSCs) taken from the blood and skin cells of super-obese individuals and people with a normal... 2 days
Cell type transcriptome atlas for the planarian Schmidtea mediterranea
Science Magazine The transcriptome of a cell dictates its unique cell-type biology. We used single-cell RNA sequencing to determine the transcriptomes for essentially every cell type of a complete animal: the regenerative... 2 days
Cell type atlas and lineage tree of a whole complex animal by single-cell transcriptomics
Science Magazine Flatworms of the species Schmidtea mediterranea are immortal—adult animals contain a large pool of pluripotent stem cells that continuously differentiate... 2 days
Natural selection interacts with recombination to shape the evolution of hybrid genomes
Science Magazine To investigate the consequences of hybridization between species, we studied three replicate hybrid populations that formed naturally between two swordtail fish species, estimating their... 2 days
Putting proteins in their proper place
PHYS.ORG A host of special molecules called nuclear RNA-binding proteins (RBPs), when misplaced outside the nucleus, form the harmful clumps seen in several brain disorders, including frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). "Clumps that form... 2 days
Homemade microscope reveals how a cancer-causing virus clings to our DNA
PHYS.ORG Using a homemade, high-tech microscope, scientists at the University of Virginia School of Medicine have revealed how a cancer-causing virus anchors itself to our DNA. That... 2 days
Indonesian divers have evolved bigger spleens to hunt underwater
Science Magazine VIDEO “Sea nomads” carry a gene that spurs spleen growth 2 days
Male fruit flies enjoy ejaculation
SCIENCE-NEWS Red light exposure made some genetically engineered fruit flies ejaculate, spurring a surge of a brain reward compound — and less desire for booze. 2 days
Medical News Today: Added to chemotherapy, this drug doubles lung cancer survival
MNT Adding immunotherapy to chemotherapy doubled survival in a trial of metastatic nonsquamous non-small cell lung cancer lacking EGFR and ALK mutations. 2 days
Why male and female cells behave differently after being reprogrammed into stem cells
PHYS.ORG Vincent Pasque from KU Leuven, Belgium, and Kathrin Plath from UCLA led an international study into how specialized cells are reprogrammed to... 2 days
Genetic adaptations to diving discovered in humans for the first time
PHYS.ORG Evidence that humans can genetically adapt to diving has been identified for the first time in a new study. The evidence suggests that the Bajau, a... 2 days
Teen patient gets a new lease on life
NEWS MEDICAL At just 18 years old, Megan Gagliardi was told she might die from a rare genetic heart condition. Now, thanks in part to UAB Medicine's Comprehensive Transplant Institute (CTI), she is celebrating... 2 days
Interaction between dioxin and HLA gene variant activates events associated with rheumatoid arthritis
NEWS MEDICAL It has been known for more than three decades that individuals with a particular version of a gene -; human leukocyte antigen... 2 days
Machine-learning software predicts behavior of bacteria
PHYS.ORG In a first for machine-learning algorithms, a new piece of software developed at Caltech can predict behavior of bacteria by reading the content of a gene. The breakthrough could have significant implications for our understanding of... 2 days
Researchers use CRISPR to edit DNA outside of the cell for the first time
PHYS.ORG Scientists at Christiana Care Health System's Gene Editing Institute have developed a potentially breakthrough CRISPR gene-editing tool. It could allow... 2 days
Long-term exposure to cold temperatures reduces diabetes and obesity, shows study
NEWS MEDICAL A new study in fat cells has revealed a molecular mechanism that controls how lifestyle choices and the external environment affect gene expression. 2 days
Human breeding practices found to be likely reason for lack of paternal DNA diversity in modern horses
PHYS.ORG A team of researchers from across Europe has found that human breeding practices, particularly... 2 days
Genetic make-up impacts long-term effectiveness of phobia treatment
NEWS MEDICAL Researchers have discovered that variations in the efficacy of psychological treatment for phobias are associated with the serotonin transporter gene. 2 days
Far-red fluorescent silk can kill harmful bacteria as biomedical and environmental remedy
PHYS.ORG A silk hybrid material attacks bacteria when illuminated by a green light, thanks to a far-red fluorescent protein researchers transferred to its genetic makeup. 2 days
Urban life leaves behind traces in the genome of bumblebees
PHYS.ORG Bumblebees living in the city have genes that differ from those of their relatives in the countryside. Although genetic differences are not major, they nevertheless may influence how... 2 days
AMSBIO’s MC-Easy minicircle technology allows sustained transgene expression in quiescent cells and tissues
NEWS MEDICAL AMSBIO announces MC-Easy™ minicircle technology for labs looking to produce sustained transgene expression in model animal generation and gene therapy research without... 2 days
New IntelliCyt Cy-Clone PLUS streamlines clone ranking and selection for cell line development
NEWS MEDICAL IntelliCyt, a Sartorius Company, and a leading provider of integrated platforms that accelerate drug discovery, antibody screening and immuno-oncology research today announced... 2 days
Dogs could be more similar to humans than we thought
PHYS.ORG Dog and human gut microbiomes have more similar genes and responses to diet than we previously thought, according to a study published in the open access journal, Microbiome. 2 days
Gene Therapy For Inherited Blood Disorder Reduced Transfusions
NPR A small study finds promise for using gene therapy to treat patients with beta-thalassemia, a blood condition that can cause severe anemia. The experimental treatment is in early development. 3 days
Scientists Identify 124 New Genes that Determine Hair Color
SCI-NEWS.COM Researchers have discovered 124 genes that play a major role in determining human hair color variation. The findings... 3 days
South Asians are descended from a mix of farmers, herders, and hunter-gatherers, ancient DNA reveals
Science Magazine Mix of ancient ancestries is surprisingly similar to Europe’s 3 days
Gates backs gene technologies in fight to end malaria
REUTERS LONDON, April 18 (Reuters) - Gene-editing technologies that alter mosquitoes' DNA could prove critical in the fight against... 3 days
Star 'DNA' Survey Could Reunite the Sun with Its Long-Lost Siblings
LIVE SCIENCE Is the sun due for a cosmic family reunion? 3 days
Decline of genetic diversity in ancient domestic stallions in Europe
Science Magazine Present-day domestic horses are immensely diverse in their maternally inherited mitochondrial DNA, yet they show very little variation on their paternally inherited Y chromosome. Although it has recently... 3 days
Parallel evolution of Batesian mimicry supergene in two Papilio butterflies, P. polytes and P. memnon
Science Magazine Batesian mimicry protects animals from predators when mimics resemble distasteful models. The female-limited Batesian mimicry in Papilio butterflies... 3 days
Heritable stress response dynamics revealed by single-cell genealogy
Science Magazine Cells often respond to environmental stimuli by activating specific transcription factors. Upon exposure to glucose limitation stress, it is known that yeast Saccharomyces cerevisiae cells dephosphorylate the general stress response factor Msn2,... 3 days
[Research Articles] Systemic administration of the antisense oligonucleotide NS-065/NCNP-01 for skipping of exon 53 in patients with Duchenne muscular dystrophy
Science Magazine Duchenne muscular dystrophy (DMD) is a lethal hereditary... 3 days
[Research Articles] CD32 is expressed on cells with transcriptionally active HIV but does not enrich for HIV DNA in resting T cells
Science Magazine The persistence of HIV... 3 days
[Research Articles] Squalene epoxidase drives NAFLD-induced hepatocellular carcinoma and is a pharmaceutical target
Science Magazine Nonalcoholic fatty liver disease (NAFLD)–induced hepatocellular carcinoma (HCC) is an emerging malignancy in the developed world; however, mechanisms that contribute to its... 3 days
On building ribossomes
PHYS.ORG Ribosomes are organelles responsible for protein synthesis in all living organisms. Ribosomes are made of proteins and RNA (Ribosomal RNA, rRNA) and putting the several elements in the right location requires a precise multi-step hierarchically ordered process. In this biogenesis,... 3 days
Protozoa detected in waste water even after treatment
PHYS.ORG A study carried out by the Water Chemistry and Microbiology group of the Universitat Politècnica de València shows that pathogenic protozoa Cryptosporidium and Giardia are present in the sludge generated by wastewater... 3 days
340,000 stars' DNA interrogated in search for sun's lost siblings
SCIENCE DAILY VIDEO Astronomers have revealed the 'DNA' of more than 340,000 stars in the Milky Way, which should help them find the siblings of the sun, now scattered across the... 3 days
How vampire bats survive on a diet of blood
PHYS.ORG VIDEO It may seem batty, but blood is the diet of choice for several species of bats. Now, scientists discover that jumping genes provide the evolutionary key to this vampiric life. 3 days
Researchers use 'top-down proteomics' strategy to get new insights into cancer
NEWS MEDICAL When a RAS gene operates normally, it acts as an on/off switch for cell signaling to control cell proliferation. But when the gene mutates, the switch... 3 days
Novel thermal phases of topological quantum matter in the lab
PHYS.ORG For the first time, a group of researchers from Universidad Complutense de Madrid, IBM, ETH Zurich, MIT and Harvard University have observed topological phases of matter of quantum... 3 days
Medical News Today: Female pattern baldness: Treatment and genetics
MNT While most women lose between 50 and 100 strands of hair per day, this hair is usually quickly replaced by new growth. When bald patches or thinning occurs, however, it... 3 days
350,000 stars' DNA interrogated in search for sun's lost siblings
PHYS.ORG An Australian-led group of astronomers working with European collaborators has revealed the "DNA" of more than 340,000 stars in the Milky Way, which should help them find the... 3 days
New study maps links between 625 genes and different chemotherapy treatments
NEWS MEDICAL Despite the great successes of targeted cancer drugs and the promise of novel immunotherapies, the vast majority of people diagnosed with cancer are still first treated... 3 days
Gene affects some women's body fat distribution and increases their diabetes risk
NEWS MEDICAL A natural variation of the gene KLF14 causes some women to store fat on their bellies and hips and puts them at significantly increased... 3 days
Scientists decipher mechanism of chemotherapy induced female infertility
NEWS MEDICAL Many chemotherapeutics act by damaging the DNA. Since cancer cells divide more often than most normal cells, they react more sensitive to DNA damaging agents. 3 days
Scientists provide insight into how gene associated with autoimmunity contributes to disease
NEWS MEDICAL Researchers have provided new insight into how a gene associated with autoimmunity contributes to disease in humans. 3 days
Some human cancers may be result of evolutionary accidents, research finds
NEWS MEDICAL New research, published in Biological Reviews and conducted by researchers from the University of Liverpool and Escola Superior de Ciências da Saúde (Brasília, Brazil) has found... 3 days
New faster, streamlined method for bowel cancer detection and treatment
NEWS MEDICAL Researchers at the South Australian Health and Medical Research Institute (SAHMRI) and the University of Adelaide have discovered a faster, more cost-effective way to determine which DNA mutations... 3 days
Bacterial 'gene swapping' affects emergence and spread of infectious diseases
NEWS MEDICAL A new study by scientists at the University of Liverpool documents, for the first time, how the ability of bacteria to swap genetic material with each other can... 3 days
Top-down approach gets to the bottom of cancer
SCIENCE DAILY By studying patient colorectal tumors, a research team characterizes a fully intact protein that results from a mutation of the RAS gene, the first cancer gene ever pinpointed in human cancer cells.... 3 days
Medical News Today: What are the signs of heart attack in a woman?
MNT Symptoms of a heart attack can often vary between males and females. Being able to spot the early signs means that prompt... 4 days
Blood test shows promise for spotting early cancers
Science Magazine Biotech giant’s DNA assays detect about 65% of several lethal tumor types in preliminary study 4 days
Researchers develop first gene drive targeting worldwide crop pest
PHYS.ORG Biologists at the University of California San Diego have developed a method of manipulating the genes of an agricultural pest that has invaded much of the United States and caused... 4 days
Lab 'Accident' Becomes Mutant Enzyme That Devours Plastic
LIVE SCIENCE A new enzyme unintentionally produced by researchers has a voracious appetite for plastic. 4 days
Indonesian divers have evolved bigger spleens to hunt underwater
Science Magazine
340,000 stars' DNA interrogated in search for sun's lost siblings
SCIENCE DAILY
How vampire bats survive on a diet of blood
PHYS.ORG
Harmful genetic mutations may be less common than we thought
PHYS.ORG
Magnetic Fields Are A Big Predictor Of A Loggerhead Turtle's Genes
NPR
Fit for porpoise: Gene changes made 'river pig' unique
PHYS.ORG
Human drugs could help treat transmissible cancers in Tasmanian devils
PHYS.ORG